Inhibition of germinal centre apoptotic programmes by epstein-barr virus [0.03%]
爱泼斯坦-巴尔病毒对生发中心凋亡程序的抑制作用
Lindsay C Spender,Gareth J Inman
Lindsay C Spender
To establish a persistent latent infection, Epstein-Barr virus (EBV) faces a challenge in that the virus-infected host cell must transit through the germinal centre reaction. This is a site of B cell differentiation where antibody responses...
Jason R Westin,Rima M Saliba,Marcos De Lima et al.
Jason R Westin et al.
Patients with steroid-resistant acute graft versus host disease (aGVHD) have a dismal prognosis, with mortality rates in excess of 90%. We sought to identify a subgroup of patients less likely to benefit from initial therapy with corticoste...
What role for angiogenesis in childhood acute lymphoblastic leukaemia? [0.03%]
儿童急性淋巴细胞白血病中血管生成的作用是什么？
P Schneider,I Dubus,F Gouel et al.
P Schneider et al.
The role of angiogenesis in acute leukaemia has been discussed since the cloning of the gene of vascular endothelial growth factor (VEGF) from the acute myelogenous leukemia cell line (HL60) and, thereafter, when the first studies reported ...
Molecular diagnostics, targeted therapy, and the indication for allogeneic stem cell transplantation in acute lymphoblastic leukemia [0.03%]
急性淋巴细胞白血病的分子诊断、靶向治疗及异基因干细胞移植指征
Anthony Oyekunle,Torsten Haferlach,Nicolaus Kröger et al.
Anthony Oyekunle et al.
In recent years, the panel of known molecular mutations in acute lymphoblastic leukemia (ALL) has been continuously increased. In Philadelphia-positive ALL, deletions of the IKZF1 gene were identified as prognostically adverse factors. Thes...
Role of factor xa inhibitors in cancer-associated thrombosis: any new data? [0.03%]
Factor Xa抑制剂在癌症相关血栓形成中的作用：有新的数据吗？
Ali Zalpour,Michael H Kroll,Vahid Afshar-Kharghan et al.
Ali Zalpour et al.
The association between cancer and venous thromboembolism (VTE) has been well documented in the literature. Prevention and treatment of VTE in cancer patients is imperative. Typically, the mainstay regimen for VTE prevention and treatment h...
Predicting the Kinetic Properties Associated with Redox Imbalance after Oxidative Crisis in G6PD-Deficient Erythrocytes: A Simulation Study [0.03%]
G6PD缺陷红细胞氧化危机后与氧化还原不平衡相关的动力学性质的预测：一种模拟研究
Hanae Shimo,Taiko Nishino,Masaru Tomita
Hanae Shimo
It is well known that G6PD-deficient individuals are highly susceptible to oxidative stress. However, the differences in the degree of metabolic alterations among patients during an oxidative crisis have not been extensively studied. In thi...
Extracellular NM23 Protein as a Therapeutic Target for Hematologic Malignancies [0.03%]
NM23蛋白作为血液系统恶性肿瘤治疗靶点的研究进展
Junko Okabe-Kado,Takashi Kasukabe,Yasuhiko Kaneko
Junko Okabe-Kado
An elevated serum level of NM23-H1 protein is a poor prognostic factor in patients with various hematologic malignancies. The extracellular NM23-H1 protein promotes the in vitro growth and survival of acute myelogenous leukemia (AML) cells ...
The Role of BCL2 Family of Apoptosis Regulator Proteins in Acute and Chronic Leukemias [0.03%]
BCL2家族凋亡调控蛋白在急慢性白血病中的作用
Flora Tzifi,Christina Economopoulou,Dimitrios Gourgiotis et al.
Flora Tzifi et al.
The disturbance of apoptosis molecular signaling pathways is involved in carcinogenesis. BCL2 family of proteins is the hallmark of apoptosis regulation. In the last decade, new members of BCL2 gene family were discovered and cloned and wer...
Korry J Hintze,James P McClung
Korry J Hintze
Iron status affects cognitive and physical performance in humans. Recent evidence indicates that iron balance is a tightly regulated process affected by a series of factors other than diet, to include hypoxia. Hypoxia has profound effects o...
Clinical usefulness of haptoglobin levels to evaluate hemolysis in recently transfused patients [0.03%]
评估近期输血患者的溶血：光化蛋白水平的临床应用价值评估近期输血患者的溶血：光化蛋白水平的临床应用价值
Shilpi Gupta,Kathleen Ahern,Fadi Nakhl et al.
Shilpi Gupta et al.
Introduction. Haptoglobin binds the globin portion of free hemoglobin. Serum haptoglobin measurement is used as a laboratory marker for the diagnosis of hemolytic anemia. Since stored blood contains free hemoglobin, transfusion may affect h...