Marrow Stromal Cell Infusion Rescues Hematopoiesis in Lethally Irradiated Mice despite Rapid Clearance after Infusion [0.03%]
移植物细胞的快速清除对其重建 lethally irradiated 小鼠造血功能的能力的影响
Xiaodong Yang,Ilango Balakrishnan,Beverly Torok-Storb et al.
Xiaodong Yang et al.
Marrow stromal cells (MSCs, also termed mesenchymal stem cells) have been proposed as a promising cellular therapy for tissue injury including radiation-induced marrow failure, but evidence for a direct effect is lacking. To assess the effe...
Matilde Cacciatore,Carla Guarnotta,Marco Calvaruso et al.
Matilde Cacciatore et al.
Aggressive B-cell lymphomas share high proliferative and invasive attitudes and dismal prognosis despite heterogeneous biological features. In the interchained sequence of events leading to cancer progression, neoplastic clone-intrinsic mol...
A role for bcl-2 in notch1-dependent transcription in thymic lymphoma cells [0.03%]
Bcl-2在胸腺淋巴瘤细胞中Notch1依赖性转录中的作用
Ronit Vogt Sionov,Shlomit Kfir-Erenfeld,Rachel Spokoini et al.
Ronit Vogt Sionov et al.
Notch1 is a transcription factor important for T-cell development. Notch1 is active in double negative (DN) thymocytes, while being depressed in double positive (DP) thymocytes. Synchronously, the expression of Bcl-2 becomes downregulated d...
Improving TCR Gene Therapy for Treatment of Haematological Malignancies [0.03%]
改善TCR基因治疗以治疗血液系统恶性肿瘤
Emma Nicholson,Sara Ghorashian,Hans Stauss
Emma Nicholson
Adoptive immunotherapy using TCR gene modified T cells may allow separation of beneficial Graft versus tumour responses from harmful GvHD. Improvements to this include methods to generate high avidity or high affinity TCR, improvements in v...
Nonengraftment haploidentical cellular therapy for hematologic malignancies [0.03%]
单倍体相合造血干细胞移植后输注非植入的淋巴细胞治疗血液系统恶性肿瘤的安全性及疗效研究
John L Reagan,Loren D Fast,Eric S Winer et al.
John L Reagan et al.
Much of the therapeutic benefit of allogeneic transplant is by a graft versus tumor effect. Further data shows that transplant engraftment is not dependant on myeloablation, instead relying on quantitative competition between donor and host...
The role of autologous stem cell transplantation in the treatment of diffuse large B-cell lymphoma [0.03%]
自体干细胞移植在弥漫大B细胞淋巴瘤治疗中的作用
Marco Gunnellini,Rita Emili,Stefano Coaccioli et al.
Marco Gunnellini et al.
Diffuse large B-cell non-Hodgkin's lymphoma (DLBCL) accounting for approximately 30% of new lymphoma diagnoses in adult patients. Complete remissions (CRs) can be achieved in 45% to 55% of patients and cure in approximately 30-35% with anth...
Towards curative therapy in burkitt lymphoma: the role of early african studies in demonstrating the value of combination therapy and CNS prophylaxis [0.03%]
Burkitt淋巴瘤的治愈性治疗：非洲早期研究证明联合化疗和中枢神经系统预防作用的价值
Ian Magrath
Ian Magrath
This paper describes the treatment of Burkitt lymphoma (BL) from the time of its discovery in Africa up to the present. Pioneer investigators explored the value of chemotherapy since surgery and radiation were not effective modalities. Comp...
In Vitro and In Vivo Antitumor Effect of Anti-CD33 Chimeric Receptor-Expressing EBV-CTL against CD33 Acute Myeloid Leukemia [0.03%]
携带Anti-CD33嵌合受体的EBVCTL的体内外抗白血病效应研究
A Dutour,V Marin,I Pizzitola et al.
A Dutour et al.
Genetic engineering of T cells with chimeric T-cell receptors (CARs) is an attractive strategy to treat malignancies. It extends the range of antigens for adoptive T-cell immunotherapy, and major mechanisms of tumor escape are bypassed. Wit...
HIV-Associated Hodgkin's Lymphoma: Prognosis and Therapy in the Era of cART [0.03%]
高效抗逆转录病毒治疗时代艾滋病相关的霍奇金淋巴瘤的预后和治疗
Caron A Jacobson,Jeremy S Abramson
Caron A Jacobson
Patients with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) are at increased risk for developing Hodgkin's lymphoma (HL), a risk that has not decreased despite the success of combination antiretroviral therapy ...
Kevin D Bunting,Cheng-Kui Qu,Michael H Tomasson
Kevin D Bunting