A Role for RNA Viruses in the Pathogenesis of Burkitt's Lymphoma: The Need for Reappraisal [0.03%]
伯基特淋巴瘤发病机制中RNA病毒的作用：需要重新评估
Corry van den Bosch
Corry van den Bosch
Certain infectious agents are associated with lymphomas, but the strength of the association varies geographically, suggesting that local environmental factors make important contributions to lymphomagenesis. Endemic Burkitt's Lymphoma has ...
Epidemiology, Diagnosis, and Treatment of HIV-Associated Non-Hodgkin Lymphoma in Resource-Limited Settings [0.03%]
资源匮乏条件下HIV相关非霍奇金淋巴瘤的流行病学、诊断和治疗
Matthew Ulrickson,Oliver W Press,Corey Casper
Matthew Ulrickson
Lymphoma was a common complication of HIV infection in the pre-antiretroviral era, and the incidence of HIV-associated lymphoma has dropped dramatically since the introduction of combination antiretroviral therapy (cART) in resource-rich re...
Sylvia Hoeller,Christiane Copie-Bergman
Sylvia Hoeller
The current classification of lymphoid neoplasms is based on clinical information, morphology, immunophenotype, and molecular genetic characteristics. Despite technical and scientific progress, some aggressive B-cell lymphomas with features...
Kenneth A Foon,Kenichi Takeshita,Pier L Zinzani
Kenneth A Foon
Aggressive B-cell lymphoma (BCL) comprises a heterogeneous group of malignancies, including diffuse large B-cell lymphoma (DLBCL), Burkitt lymphoma, and mantle cell lymphoma (MCL). DLBCL, with its 3 subtypes, is the most common type of lymp...
PI3K/AKT/PTEN Signaling as a Molecular Target in Leukemia Angiogenesis [0.03%]
磷脂酰肌醇-3-激酶/蛋白激酶B/磷酸酶和张力蛋白同源物信号传导作为白血病血管生成的分子靶标
Naoko Okumura,Hitomi Yoshida,Yasuko Kitagishi et al.
Naoko Okumura et al.
PI3K/AKT/PTEN pathway is important in the regulation of angiogenesis mediated by vascular endothelial growth factor in many tumors including leukemia. The signaling pathway is activated in leukemia patients as well as leukemia cell lines to...
Current status of new anticoagulants in the management of venous thromboembolism [0.03%]
新型抗凝药物在静脉血栓栓塞治疗中的应用现状
Roberto C Montoya,Ajeet Gajra
Roberto C Montoya
Venous Thromboembolism, manifested as deep venous thrombosis and pulmonary embolism, is a common problem associated with significant morbidity, mortality, and resource expenditure. Unfractionated heparin, low-molecular-weight heparin, and v...
Anaplastic lymphoma kinase-positive large B-cell lymphoma: an underrecognized aggressive lymphoma [0.03%]
阳性的ALK重排型大B细胞淋巴瘤：一种被低估的侵袭性淋巴瘤
Elizabeth A Morgan,Alessandra F Nascimento
Elizabeth A Morgan
Anaplastic lymphoma kinase-(ALK-) positive large B-cell lymphoma (ALK+ LBCL) is a rare, aggressive tumor characterized by an immunoblastic or plasmablastic morphologic appearance, expression of ALK, CD138, CD45, EMA, and often IgA by immuno...
Murine models of B-cell lymphomas: promising tools for designing cancer therapies [0.03%]
小鼠B细胞淋巴瘤模型：设计癌症疗法的有力工具
Sabrina Donnou,Claire Galand,Valérie Touitou et al.
Sabrina Donnou et al.
Human B-cell lymphomas, the fourth most common hematologic malignancy, are currently the subject of extensive research. The limited accessibility of biopsies, the heterogeneity among patients, and the subtypes of lymphomas have necessitated...
JAK2 Inhibition: Reviewing a New Therapeutical Option in Myeloproliferative Neoplasms [0.03%]
JAK2抑制：回顾一种新的治疗方法在髓系增生性肿瘤中的应用
Mar Bellido,Peter A W Te Boekhorst
Mar Bellido
JAK2 is a tyrosine kinase gene that plays an essential role in the development of normal haematopoiesis. Hyperactivation of JAK2 occurs in myeloproliferative neoplasms by different mechanisms. As a consequence, JAK2 inhibitors have been des...
AIDS-Related Non-Hodgkin's Lymphoma in the Era of Highly Active Antiretroviral Therapy [0.03%]
高效抗逆转录病毒治疗时代的新时代艾滋病相关非霍奇金淋巴瘤
Prakash Vishnu,David M Aboulafia
Prakash Vishnu
In economically developed countries, AIDS-related lymphoma (ARL) accounts for a large proportion of malignances in HIV-infected individuals. Since the introduction of highly active anti-retroviral therapy (HAART) in 1996, epidemiology and p...