Lenalidomide in the treatment of young patients with multiple myeloma: from induction to consolidation/maintenance therapy [0.03%]
来那度胺在年轻多发性骨髓瘤患者治疗中的应用：从诱导到巩固/维持疗法
Barbara Lupo,Antonio Palumbo
Barbara Lupo
Multiple myeloma is the second most common hematologic malignancy. It accounts for 20,580 new cancer cases in the USA in 2009, including 11,680 cases in men, 8,900 cases in women, and 10,580 deaths overall. Although the disease remains stil...
Through the looking glass: visualizing leukemia growth, migration, and engraftment using fluorescent transgenic zebrafish [0.03%]
穿越魔镜：利用荧光转基因斑马鱼可视化白血病的生长、转移和植入现象
Finola E Moore,David M Langenau
Finola E Moore
Zebrafish have emerged as a powerful model of development and cancer. Human, mouse, and zebrafish malignancies exhibit striking histopathologic and molecular similarities, underscoring the remarkable conservation of genetic pathways require...
Pathogen recognition and activation of the innate immune response in zebrafish [0.03%]
病原体识别和斑马鱼固有免疫反应的激活
Michiel van der Vaart,Herman P Spaink,Annemarie H Meijer
Michiel van der Vaart
The zebrafish has proven itself as an excellent model to study vertebrate innate immunity. It presents us with possibilities for in vivo imaging of host-pathogen interactions which are unparalleled in mammalian model systems. In addition, i...
Annalisa Chiappella,Umberto Vitolo
Annalisa Chiappella
Diffuse Large B-cell Lymphomas (DLBCL) are the most frequent Non-Hodgkin Lymphomas (NHL). The addition of Rituximab to the standard chemotherapy CHOP improved the outcome in this patients, but so far 40% of patients experienced relapse or p...
Gauri Khandekar,Seongcheol Kim,Pudur Jagadeeswaran
Gauri Khandekar
Platelets play an important role in mammalian hemostasis. Thrombocytes of early vertebrates are functionally equivalent to mammalian platelets. A substantial amount of research has been done to study platelet function in humans as well as i...
In vivo chemical screening for modulators of hematopoiesis and hematological diseases [0.03%]
用于血液生成和血液病调节因子的体内化学筛选研究
Yiyun Zhang,J-R Joanna Yeh
Yiyun Zhang
In vivo chemical screening is a broadly applicable approach not only for dissecting genetic pathways governing hematopoiesis and hematological diseases, but also for finding critical components in those pathways that may be pharmacologicall...
Jill L O de Jong,Leonard I Zon
Jill L O de Jong
The zebrafish has proven to be an excellent model for human disease, particularly hematopoietic diseases, since these fish make similar types of blood cells as humans and other mammals. The genetic program that regulates the development and...
Therapeutic Activity of Lenalidomide in Mantle Cell Lymphoma and Indolent Non-Hodgkin's Lymphomas [0.03%]
来那度胺治疗套细胞淋巴瘤和惰性非霍奇金淋巴瘤的疗效
Marco Gunnellini,Lorenzo Falchi
Marco Gunnellini
Mantle cell lymphoma (MCL) comprises 3-10% of NHL, with survival times ranging from 3 and 5 years. Indolent lymphomas represent approximately 30% of all NHLs with patient survival largely dependent on validated prognostic scores. High respo...
Heather A Leitch,Jeremy S Abramson,Matthew C Cheung et al.
Heather A Leitch et al.
Genomic amplification of an endogenous retrovirus in zebrafish T-cell malignancies [0.03%]
斑马鱼T细胞恶性肿瘤中内源性逆转录病毒的基因组扩增
J Kimble Frazer,Lance A Batchelor,Diana F Bradley et al.
J Kimble Frazer et al.
Genomic instability plays a crucial role in oncogenesis. Somatically acquired mutations can disable some genes and inappropriately activate others. In addition, chromosomal rearrangements can amplify, delete, or even fuse genes, altering th...