Synergistic effect of anemia and red blood cells transfusion on inflammation and lung injury [0.03%]
贫血和输血对炎症及肺损伤的协同效应研究
Anping Dong,Manjula Sunkara,Manikandan Panchatcharam et al.
Anping Dong et al.
Anemia and resultant red blood cell transfusion may be associated with adverse long-term clinical outcomes. To investigate the mechanism(s) responsible, we profiled inflammatory biomarkers and circulating levels of the bioactive lysophospho...
Biological activity of lenalidomide and its underlying therapeutic effects in multiple myeloma [0.03%]
来那度胺的生物活性及其在多发性骨髓瘤治疗中的潜在作用机制研究
Roberta Martiniani,Valentina Di Loreto,Chiara Di Sano et al.
Roberta Martiniani et al.
Lenalidomide is a synthetic compound derived by modifying the chemical structure of thalidomide. It belongs to the second generation of immunomodulatory drugs (IMiDs) and possesses pleiotropic properties. Even if lenalidomide has been shown...
Drift-Diffusion Analysis of Neutrophil Migration during Inflammation Resolution in a Zebrafish Model [0.03%]
斑马鱼炎症消退模型中中性粒细胞迁移的漂移扩散分析
Geoffrey R Holmes,Giles Dixon,Sean R Anderson et al.
Geoffrey R Holmes et al.
Neutrophils must be removed from inflammatory sites for inflammation to resolve. Recent work in zebrafish has shown neutrophils can migrate away from inflammatory sites, as well as die in situ. The signals regulating the process of reverse ...
Novel insights into the genetic controls of primitive and definitive hematopoiesis from zebrafish models [0.03%]
斑马鱼模型在探究原始和定局性血液发育的遗传机制方面的新见解
Raman Sood,Paul Liu
Raman Sood
Hematopoiesis is a dynamic process where initiation and maintenance of hematopoietic stem cells, as well as their differentiation into erythroid, myeloid and lymphoid lineages, are tightly regulated by a network of transcription factors. Un...
Molecular action of lenalidomide in lymphocytes and hematologic malignancies [0.03%]
来那度胺在淋巴细胞和血液系统恶性肿瘤中的分子作用机制研究进展
Jessica M McDaniel,Javier Pinilla-Ibarz,P K Epling-Burnette
Jessica M McDaniel
The immunomodulatory agent, lenalidomide, is a structural analogue of thalidomide approved by the US Food and Drug Administration for the treatment of myelodysplastic syndrome (MDS) and multiple myeloma (MM). This agent is also currently un...
Secondary primary malignancies in multiple myeloma: an old NEMESIS revisited [0.03%]
多发性骨髓瘤中的继发性原发恶性肿瘤：重访NEMESIS
Jay Yang,Howard R Terebelo,Jeffrey A Zonder
Jay Yang
The treatment of myeloma has undergone extraordinary improvements in the past half century. These advances have been accompanied by a concern for secondary primary malignancies (SPMs). It has been known for decades that extended therapy wit...
Agostino Cortelezzi,Mariarita Sciumè,Gianluigi Reda
Agostino Cortelezzi
The application of nucleoside analogue-based chemotherapy and immunotherapy with rituximab or alemtuzumab has increased both response rate and survival in patients with Chronic Lymphocytic Leukemia (CLL). However, because none of these ther...
A Michael Forrester,Jason N Berman,Elspeth M Payne
A Michael Forrester
Over the past ten years, studies using the zebrafish model have contributed to our understanding of vertebrate haematopoiesis, myelopoiesis, and myeloid leukaemogenesis. Novel insights into the conservation of haematopoietic lineages and im...
The Effect of Taraxacum officinale Hydroalcoholic Extract on Blood Cells in Mice [0.03%]
Taraxacum officinale氢醇提取物对小鼠血液细胞的影响
Mehrdad Modaresi,Narges Resalatpour
Mehrdad Modaresi
Objectives. Dandelion (Taraxacum officinale) is a herbaceous perennial plant of the family Asteraceae and has medicinal and culinary uses. Dandelion has been used as a remedy for anemia, purifing the blood, and providing immune modulation. ...
Taylor W Starnes,Anna Huttenlocher
Taylor W Starnes
The precise control of neutrophil-mediated inflammation is critical for both host defense and the prevention of immunopathology. In vivo imaging studies in zebrafish, and more recently in mice, have made the novel observation that neutrophi...