beta-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload [0.03%]
β-地中海贫血：HiJAK ineffective erythropoiesis和iron overload
Luca Melchiori,Sara Gardenghi,Stefano Rivella
Luca Melchiori
beta-thalassemia encompasses a group of monogenic diseases that have in common defective synthesis of beta-globin. The defects involved are extremely heterogeneous and give rise to a large phenotypic spectrum, with patients that are almost ...
Radha Raghupathy,Deepa Manwani,Jane A Little
Radha Raghupathy
In sickle cell disease transfusions improve blood flow by reducing the proportion of red cells capable of forming sickle hemoglobin polymer. This limits hemolysis and the endothelial damage that result from high proportions of sickle polyme...
Treatment outcome of acute promyelocytic leukemia with modified aida protocol [0.03%]
改良AIDA方案治疗急性早幼粒细胞白血病的疗效分析
Kátia B Barbosa Pagnano,Gustavo de Carvalho Duarte,Irene Lorand-Metze et al.
Kátia B Barbosa Pagnano et al.
We analyzed the outcome of a series of 19 newly diagnosed patients with acute promyelocytic leukemia treated with AIDA modified protocol, using mitoxantrone in place of idarubicin. Eleven patients achieved morphologic CR (58%). The remainin...
Toshihiko Tanno,Jeffery L Miller
Toshihiko Tanno
Erythropoiesis describes the hematopoietic process of cell proliferation and differentiation that results in the production of mature circulating erythrocytes. Adult humans produce 200 billion erythrocytes daily, and approximately 1 billion...
Diamond Blackfan Anemia at the Crossroad between Ribosome Biogenesis and Heme Metabolism [0.03%]
核糖体生物发生与血红素代谢之间的先天性纯红细胞再生障碍性贫血
Deborah Chiabrando,Emanuela Tolosano
Deborah Chiabrando
Diamond-Blackfan anemia (DBA) is a rare, pure red-cell aplasia that presents during infancy. Approximately 40% of cases are associated with other congenital defects, particularly malformations of the upper limb or craniofacial region. Mutat...
Sweet Syndrome due to Myelodysplastic Syndrome: Possible Therapeutic Role of Intravenous Immunoglobulin in Addition to Standard Treatment [0.03%]
骨髓增生异常综合征所致甜综合症标准治疗基础上加用静脉注射免疫球蛋白的可能治疗作用
Harry H S Gill,Anskar Y H Leung,N J Trendell-Smith et al.
Harry H S Gill et al.
We report an 82-year-old lady who developed sudden onset nodular and erythematous lesions and neutrophilia following an episode of urinary tract infection. Skin biopsy confirmed the diagnosis of Sweet syndrome. Response to the use of predni...
Case Reports
Advances in hematology. 2010:2010:328316. DOI:10.1155/2010/328316 2010
Elizabeth A Price,Stanley L Schrier
Elizabeth A Price
Anemia of inflammation (AI), also known as anemia of chronic inflammation or anemia of chronic disease was described over 50 years ago as anemia in association with clinically overt inflammatory disease, and the findings of low plasma iron,...
Red blood cell transfusion independence following the initiation of iron chelation therapy in myelodysplastic syndrome [0.03%]
铁螯合治疗对骨髓增生异常综合征患者输血依赖性的影响研究
Maha A Badawi,Linda M Vickars,Jocelyn M Chase et al.
Maha A Badawi et al.
Iron chelation therapy is often used to treat iron overload in patients requiring transfusion of red blood cells (RBC). A 76-year-old man with MDS type refractory cytopenia with multilineage dysplasia, intermediate-1 IPSS risk, was referred...
Case Reports
Advances in hematology. 2010:2010:164045. DOI:10.1155/2010/164045 2010
Promyelocytic sarcoma of the spine: a case report and review of the literature [0.03%]
脊柱粒细胞性肉瘤一例并文献复习
Leonardo Pacilli,Francesco Lo Coco,Safaa Mahmoud Ramadan et al.
Leonardo Pacilli et al.
Myeloid sarcoma (MS, previously named granulocytic sarcoma or chloroma) is a rare extramedullary tumour of immature myeloid cells. It can be present before, concurrently with, or after the diagnosis of acute myeloid leukemia. MS is extremel...
Case Reports
Advances in hematology. 2010:2010:137608. DOI:10.1155/2010/137608 2010
Ethan A Natelson,David Pyatt
Ethan A Natelson
A patient who had received temozolomide (TMZ) as a single agent in treatment of malignant glioma developed therapy-induced myelodysplasia (T-MDS). TMZ is an orally active imidazotetrazine which methylates guanine residues in DNA, ultimately...
Case Reports
Advances in hematology. 2010:2010:760402. DOI:10.1155/2010/760402 2010