Catherine Thieblemont,Marie-Hélène Delfau-Larue,Bertrand Coiffier
Catherine Thieblemont
Diffuse large B-cell lymphoma (DLBCL) is the most common form of non-Hodgkin's lymphoma (NHL) in adults. Even if the natural history of DLBCL has been improved with the advent of immunochemotherapy, the survival results obtained with curren...
DNMT3A Mutations in Patients with Acute Myeloid Leukemia in South Brazil [0.03%]
南巴西急性髓系白血病患者中DNMT3A基因突变的研究
Annelise Pezzi,Lauro Moraes,Vanessa Valim et al.
Annelise Pezzi et al.
Acute myeloid leukemia (AML) is a complex and heterogeneous hematopoietic tissue neoplasm. Several molecular markers have been described that help to classify AML patients into risk groups. DNA methyltransferase 3A (DNMT3A) gene mutations h...
Practical approaches to the use of lenalidomide in multiple myeloma: a canadian consensus [0.03%]
来那度胺在多发性骨髓瘤中应用的实践方案：加拿大共识观点
Donna Reece,C Tom Kouroukis,Richard Leblanc et al.
Donna Reece et al.
In Canada, lenalidomide combined with dexamethasone (Len/Dex) is approved for use in relapsed or refractory multiple myeloma (RRMM). Our expert panel sought to provide an up-to-date practical guide on the use of lenalidomide in the managing...
The zebrafish as a tool to study hematopoiesis, human blood diseases, and immune function [0.03%]
斑马鱼在探究血液学、人类血液疾病和免疫功能方面的作用
Jason Berman,Elspeth Payne,Christopher Hall
Jason Berman
Bone Marrow and Peripheral Blood AML Cells Are Highly Sensitive to CNDAC, the Active Form of Sapacitabine [0.03%]
骨髓和外周血AML细胞对sapacitabine活性形式CNDAC敏感性高
Sucheta Jagan,Laura A Paganessi,Robin R Frank et al.
Sucheta Jagan et al.
Achieving improvements in survival and reducing relapse remains a challenge in acute myelogenous leukemia (AML) patients. This study evaluated the in vitro efficacy of the active form of novel agent sapacitabine, CNDAC, compared to current ...
Radhika N Shah,Ivan Rodriguez-Nunez,Donna D Eason et al.
Radhika N Shah et al.
The novel immune-type receptors (NITRs), which have been described in numerous bony fish species, are encoded by multigene families of inhibitory and activating receptors and are predicted to be functional orthologs to the mammalian natural...
Association of xmn I polymorphism and hemoglobin e haplotypes on postnatal gamma globin gene expression in homozygous hemoglobin e [0.03%]
血红蛋白E纯合子新生儿γ珠蛋白数量的遗传决定因素研究
Supachai Ekwattanakit,Yuwarat Monteerarat,Suchada Riolueang et al.
Supachai Ekwattanakit et al.
Background and Objectives. To explore the role of cis-regulatory sequences within the β globin gene cluster at chromosome 11 on human γ globin gene expression related to Hb E allele, we analyze baseline hematological data and Hb F values ...
Characterization of zebrafish von Willebrand factor reveals conservation of domain structure, multimerization, and intracellular storage [0.03%]
斑马鱼von Willebrand因子的特性研究发现结构域结构、多聚化和细胞内储存的保守性
Arunima Ghosh,Andy Vo,Beverly K Twiss et al.
Arunima Ghosh et al.
von Willebrand disease (VWD) is the most common inherited human bleeding disorder and is caused by quantitative or qualitative defects in von Willebrand factor (VWF). VWF is a secreted glycoprotein that circulates as large multimers. While ...
Alexander J Ambinder,Pareen J Shenoy,Neha Malik et al.
Alexander J Ambinder et al.
Follicular lymphoma (FL) is an indolent malignancy of germinal center B cells with varied incidence across racial groups and geographic regions. Improvements in the classification of non-Hodgkin lymphoma subtypes provide an opportunity to e...
Crosstalk between Platelets and the Immune System: Old Systems with New Discoveries [0.03%]
platelet和免疫系统之间的相互作用：老系统中新发现
Conglei Li,June Li,Yan Li et al.
Conglei Li et al.
Platelets are small anucleate cells circulating in the blood. It has been recognized for more than 100 years that platelet adhesion and aggregation at the site of vascular injury are critical events in hemostasis and thrombosis; however, re...