Advances in Virus-Directed Therapeutics against Epstein-Barr Virus-Associated Malignancies [0.03%]
针对EB病毒相关恶性肿瘤的病毒导向治疗新进展
Sajal K Ghosh,Susan P Perrine,Douglas V Faller
Sajal K Ghosh
Epstein-Barr virus (EBV) is the causal agent in the etiology of Burkitt's lymphoma and nasopharyngeal carcinoma and is also associated with multiple human malignancies, including Hodgkin's and non-Hodgkin's lymphoma, and posttransplantation...
P Gerner,Andre Hörning,S Kathemann et al.
P Gerner et al.
Background. It has been suggested that chronic hepatitis B infection leads to growth impairment, but data are inconsistent and underlying factors are not defined. Methods. Children and adolescents with chronic hepatitis B (HBV) or C (HCV) w...
The symptom and genetic diversity of cassava brown streak viruses infecting cassava in East Africa [0.03%]
东非木薯区褐色条纹病症状及基因多样性研究
I U Mohammed,M M Abarshi,B Muli et al.
I U Mohammed et al.
The genetic and symptom diversity of six virus isolates causing cassava brown streak disease (CBSD) in the endemic (Kenya, Mozambique, and Tanzania) and the recently affected epidemic areas (Uganda) of eastern Africa was studied. Five cassa...
Mark S Ferguson,Nicholas R Lemoine,Yaohe Wang
Mark S Ferguson
Despite recent advances in both surgery and chemoradiotherapy, mortality rates for advanced cancer remain high. There is a pressing need for novel therapeutic strategies; one option is systemic oncolytic viral therapy. Intravenous administr...
Near-full genome characterisation of two natural intergenotypic 2k/1b recombinant hepatitis C virus isolates [0.03%]
两个自然的2K/1B型丙型肝炎病毒重组分离株的近全基因组表征
Victoria L Demetriou,Eftychia Kyriakou,Leondios G Kostrikis
Victoria L Demetriou
Few natural intergenotypic hepatitis C virus (HCV) recombinants have been characterised, and only RF1_2k/1b has demonstrated widespread transmission. The near-full length genome sequences for two cases of 2k/1b recombinants (CYHCV037 and CY...
Annamaria Pratelli
Annamaria Pratelli
Since the first identification of the virus in 1971, the disease caused by canine coronavirus (CCoV) has not been adequately investigated, and the role that the virus plays in canine enteric illness has not been well established. Only after...
Phylogeny-directed search for murine leukemia virus-like retroviruses in vertebrate genomes and in patients suffering from myalgic encephalomyelitis/chronic fatigue syndrome and prostate cancer [0.03%]
基于系统发育的脊椎动物基因组和肌痛性脑脊髓炎/慢性疲劳综合征及前列腺癌患者中类鼠白血病病毒相关逆转录病毒的筛查研究
Jonas Blomberg,Ali Sheikholvaezin,Amal Elfaitouri et al.
Jonas Blomberg et al.
Gammaretrovirus-like sequences occur in most vertebrate genomes. Murine Leukemia Virus (MLV) like retroviruses (MLLVs) are a subset, which may be pathogenic and spread cross-species. Retroviruses highly similar to MLLVs (xenotropic murine r...
Human Coronaviruses HCoV-NL63 and HCoV-HKU1 in Hospitalized Children with Acute Respiratory Infections in Beijing, China [0.03%]
中国北京急性呼吸道感染住院儿童中的人类冠状病毒HCoV-NL63和HCoV-HKU1
Li-Jin Cui,Chen Zhang,Ting Zhang et al.
Li-Jin Cui et al.
The human coronaviruses (HCoVs) HCoV-NL63 and HCoV-HKU1 are two recently discovered coronaviruses that circulate widely and are associated with acute respiratory infections (ARI). We detected HCoV-NL63 and HCoV-HKU1 in specimens collected f...
M H Verheije,P J M Rottier
M H Verheije
Oncolytic virus therapy is based on the ability of viruses to effectively infect and kill tumor cells without destroying the normal tissues. While some viruses seem to have a natural preference for tumor cells, most viruses require the modi...
Deciphering the Multifaceted Relationship between Oncolytic Viruses and Natural Killer Cells [0.03%]
解码溶瘤病毒与自然杀伤细胞的复杂关系
Christopher A Alvarez-Breckenridge,Jianhua Yu,Balveen Kaur et al.
Christopher A Alvarez-Breckenridge et al.
Despite active research in virotherapy, this apparently safe modality has not achieved widespread success. The immune response to viral infection appears to be an essential factor that determines the efficacy of oncolytic viral therapy. The...