The Role of the Endothelium in HPS Pathogenesis and Potential Therapeutic Approaches [0.03%]
HPS发病机制中的内皮细胞作用及潜在治疗途径
Irina Gavrilovskaya,Elena Gorbunova,Valery Matthys et al.
Irina Gavrilovskaya et al.
American hantaviruses cause a highly lethal acute pulmonary edema termed hantavirus pulmonary syndrome (HPS). Hantaviruses nonlytically infect endothelial cells and cause dramatic changes in barrier functions of the endothelium without disr...
Maria Giovanna Quaranta,Benedetta Mattioli,Stefano Vella
Maria Giovanna Quaranta
Since the identification of HIV and HCV much progress has been made in the understanding of their life cycle and interaction with the host immune system. Despite these viruses markedly differ in their virological properties and in their pat...
Oncolytic viruses [0.03%]
溶瘤病毒
Nanhai G Chen,Aladar A Szalay,R Mark L Buller et al.
Nanhai G Chen et al.
Eirini I Rigopoulou,Daniel S Smyk,Claire E Matthews et al.
Eirini I Rigopoulou et al.
The pathogenesis of autoimmune diseases includes a combination of genetic factors and environmental exposures including infectious agents. Infectious triggers are commonly indicated as being involved in the induction of autoimmune disease, ...
Budding of Enveloped Viruses: Interferon-Induced ISG15-Antivirus Mechanisms Targeting the Release Process [0.03%]
enveloped病毒芽生：干扰素诱导的ISG15抗病毒机制作用于病毒释放过程
Eun Joo Seo,Jonathan Leis
Eun Joo Seo
Pathogenic strains of viruses that infect humans are encapsulated in membranes derived from the host cell in which they infect. After replication, these viruses are released by a budding process that requires cell/viral membrane scission. A...
Interplay between HIV-1 and Host Genetic Variation: A Snapshot into Its Impact on AIDS and Therapy Response [0.03%]
HIV-1与宿主基因多态性之间的相互作用：对艾滋病及其治疗反应的影响综述
Raghavan Sampathkumar,Elnaz Shadabi,Ma Luo
Raghavan Sampathkumar
As of February 2012, 50 circulating recombinant forms (CRFs) have been reported for HIV-1 while one CRF for HIV-2. Also according to HIV sequence compendium 2011, the HIV sequence database is replete with 414,398 sequences. The fact that th...
Antibody-Dependent Cellular Cytotoxicity and NK Cell-Driven Immune Escape in HIV Infection: Implications for HIV Vaccine Development [0.03%]
HIV感染中的抗体依赖的细胞毒性作用和NK细胞驱动的免疫逃逸与HIV疫苗研发的启示
Gamze Isitman,Ivan Stratov,Stephen J Kent
Gamze Isitman
The HIV-1 genome is malleable and a difficult target tot vaccinate against. It has long been recognised that cytotoxic T lymphocytes and neutralising antibodies readily select for immune escape HIV variants. It is now also clear that NK cel...
David Almond,Chavdar Krachmarov,James Swetnam et al.
David Almond et al.
HIV-1's subtype C V3 loop consensus sequence exhibits increased resistance to anti-V3 antibody-mediated neutralization as compared to the subtype B consensus sequence. The dynamic 3D structure of the consensus C V3 loop crown, visualized by...
W Abbas,G Herbein
W Abbas
The introduction of highly active antiretroviral therapy (HAART) has been an important breakthrough in the treatment of HIV-1 infection and has also a powerful tool to upset the equilibrium of viral production and HIV-1 pathogenesis. Despit...
Protein Kinase C: One Pathway towards the Eradication of Latent HIV-1 Reservoirs [0.03%]
蛋白激酶C：消除潜伏HIV-1储存库的一个途径
Lisa N McKernan,David Momjian,Joseph Kulkosky
Lisa N McKernan
An effective means to eradicate latent reservoirs in HIV-1-infected individuals remains elusive. Attempts to purge these reservoirs were undertaken over a decade ago without success. The subsequent lapse in further clinical attempts since m...