Association of active human herpesvirus-6, -7 and parvovirus b19 infection with clinical outcomes in patients with myalgic encephalomyelitis/chronic fatigue syndrome [0.03%]
人类疱疹病毒-6、-7及B19活跃感染与肌痛性脑脊髓炎/慢性疲劳综合征临床结局之间的关联
Svetlana Chapenko,Angelika Krumina,Inara Logina et al.
Svetlana Chapenko et al.
Frequency of active human herpesvirus-6, -7 (HHV-6, HHV-7) and parvovirus B19 (B19) infection/coinfection and its association with clinical course of ME/CFS was evaluated. 108 ME/CFS patients and 90 practically healthy persons were enrolled...
Inhibition of Indoleamine-2,3-dioxygenase (IDO) in Glioblastoma Cells by Oncolytic Herpes Simplex Virus [0.03%]
溶瘤性单纯疱疹病毒抑制胶质母细胞瘤细胞中色氨酸酶(IDO)的作用
Bonnie Reinhart,Lucia Mazzacurati,Adriana Forero et al.
Bonnie Reinhart et al.
Successful oncolytic virus treatment of malignant glioblastoma multiforme depends on widespread tumor-specific lytic virus replication and escape from mitigating innate immune responses to infection. Here we characterize a new HSV vector, J...
Valery Matthys,Erich R Mackow
Valery Matthys
Hantaviruses primarily infect human endothelial cells (ECs) and cause two highly lethal human diseases. Early addition of Type I interferon (IFN) to ECs blocks hantavirus replication and thus for hantaviruses to be pathogenic they need to p...
Sergei N Shchelkunov
Sergei N Shchelkunov
In the course of evolution, viruses have developed various molecular mechanisms to evade the defense reactions of the host organism. When understanding the mechanisms used by viruses to overcome manifold defense systems of the animal organi...
Structural Diversity in Conserved Regions Like the DRY-Motif among Viral 7TM Receptors-A Consequence of Evolutionary Pressure? [0.03%]
保守区(如DRY基序)在病毒七次跨膜受体中的结构多样性是进化压力的结果吗?
Ann-Sofie Mølleskov Jensen,Alexander Hovard Sparre-Ulrich,Nicholas Davis-Poynter et al.
Ann-Sofie Mølleskov Jensen et al.
Several herpes- and poxviruses have captured chemokine receptors from their hosts and modified these to their own benefit. The human and viral chemokine receptors belong to class A 7 transmembrane (TM) receptors which are characterized by s...
Luna Li,Satinder Dahiya,Sandhya Kortagere et al.
Luna Li et al.
The human immunodeficiency virus type 1 (HIV-1) promoter or long-terminal repeat (LTR) regulates viral gene expression by interacting with multiple viral and host factors. The viral transactivator protein Tat plays an important role in tran...
Thomas Wurdinger,Natosha N Gatson,Leonora Balaj et al.
Thomas Wurdinger et al.
Extracellular vesicles (microvesicles), such as exosomes and shed microvesicles, contain a variety of molecules including proteins, lipids, and nucleic acids. Microvesicles appear mostly to originate from multivesicular bodies or to bud fro...
Cristina Simona Strahotin,Michael Babich
Cristina Simona Strahotin
Hepatitis C (HCV), a leading cause of chronic liver disease, cirrhosis, and hepatocellular carcinoma, is the most common indication for liver transplantation in the United States. Although annual incidence of infection has declined since th...
In Silico and In Vitro Comparison of HIV-1 Subtypes B and CRF02_AG Integrases Susceptibility to Integrase Strand Transfer Inhibitors [0.03%]
HIV-1 subtype B和CRF02_AG整合酶对整合酶 strand transfer 抑制剂敏感性：计算机模拟与体外试验比较研究
Xiaoju Ni,Safwat Abdel-Azeim,Elodie Laine et al.
Xiaoju Ni et al.
Most antiretroviral medical treatments were developed and tested principally on HIV-1 B nonrecombinant strain, which represents less than 10% of the worldwide HIV-1-infected population. HIV-1 circulating recombinant form CRF02_AG is prevale...
Carl I Odom,David C Gaston,James M Markert et al.
Carl I Odom et al.
Human herpesviruses cause diseases of considerable morbidity and mortality, ranging from encephalitis to hematologic malignancies. As evidence emerges about the role of innate immunity and natural killer (NK) cells in the control of herpesv...