Genetic Polymorphisms in Genes Related to Oxidative Stress (GSTP1, GSTM1, GSTT1, CAT, MnSOD, MPO, eNOS) and Survival of Rectal Cancer Patients after Radiotherapy [0.03%]
与氧化应激相关基因（GSTP1，GSTM1，GSTT1，CAT，MnSOD，MPO，eNOS）多态性与放射治疗后直肠癌患者生存率关系的研究
Silvia Funke,Angela Risch,Alexandra Nieters et al.
Silvia Funke et al.
Radiotherapy exerts part of its antineoplastic effect by generating oxidative stress, therefore genetic variation in oxidative stress-related enzymes may influence survival of rectal cancer patients. We hypothesized that genetic polymorphis...
Retinoblastoma and the genetic theory of cancer: an old paradigm trying to survive to the evidence [0.03%]
视网膜母细胞瘤与癌的遗传理论：一个旧范例试图在证据面前生存下来
Domenico Mastrangelo,Theodora Hadjistilianou,Sonia De Francesco et al.
Domenico Mastrangelo et al.
Retinoblastoma (Rb) is considered to represent the prototype of cancer linked to the sequential loss or inactivation of both alleles of a so-called "tumor suppressor gene", the Rb1 gene. The pathogenetic mechanism behind this tumor was firs...
Chromosome 5p Region SNPs Are Associated with Risk of NSCLC among Women [0.03%]
女性5号染色体短臂区域的SNPs与NSCLC发病风险相关性研究
Alison L Van Dyke,Michele L Cote,Angela S Wenzlaff et al.
Alison L Van Dyke et al.
In a population-based case-control study, we explored the associations between 42 polymorphisms in seven genes in this region and non-small cell lung cancer (NSCLC) risk among Caucasian (364 cases; 380 controls) and African American (95 cas...
Predictors of venous thromboembolism in patients with advanced common solid cancers [0.03%]
晚期常见实体瘤患者静脉血栓栓塞症的预测因素分析
Isaac E Hall,Martin S Andersen,Harlan M Krumholz et al.
Isaac E Hall et al.
There is uncertainty about risk heterogeneity for venous thromboembolism (VTE) in older patients with advanced cancer and whether patients can be stratified according to VTE risk. We performed a retrospective cohort study of the linked Medi...
Assessing Candidate Gene nsSNPs for Phenotypic Differences in Double-Strand Break Repair Using Radiation-Induced gammaH2A.X Foci [0.03%]
利用辐射诱导的γH2A.X焦点表型差异评估双链断裂修复候选基因上的nsSNPs
Christina A Markunas,David M Umbach,Zongli Xu et al.
Christina A Markunas et al.
Nonsynonymous SNPs (nsSNPs) in DNA repair genes may be important determinants of DNA damage and cancer risk. We applied a set of screening criteria to a large number of nsSNPs and selected a subset of SNPs that were likely candidates for ph...
M Singh,S Mehrotra,N Kalra et al.
M Singh et al.
The majority of squamous cell carcinomas of cervix are preceded by visible changes in the cervix, most often detected by cervical smear. As cervical cancer is preceded by long precancerous stages, identification of the high-risk population ...
Genetic and epigenetic tumor suppressor gene silencing are distinct molecular phenotypes driven by growth promoting mutations in nonsmall cell lung cancer [0.03%]
非小细胞肺癌生长促进基因改变驱动的遗传和表观遗传抑癌基因沉默两种不同的分子表型
Carmen J Marsit,E Andres Houseman,Heather H Nelson et al.
Carmen J Marsit et al.
Both genetic and epigenetic alterations characterize human nonsmall cell lung cancer (NSCLC), but the biological processes that create or select these alterations remain incompletely investigated. Our hypothesis posits that a roughly recipr...
Single Nucleotide Polymorphisms in Selected Apoptotic Genes and BPDE-Induced Apoptotic Capacity in Apparently Normal Primary Lymphocytes: A Genotype-Phenotype Correlation Analysis [0.03%]
凋亡基因多态性与表观正常人外周血淋巴细胞内源性凋亡能力的关联研究
Zhibin Hu,Chunying Li,Kexin Chen et al.
Zhibin Hu et al.
Apoptotic capacity (AC) in primary lymphocytes may be a marker for cancer susceptibility, and functional single nucleotide polymorphisms (SNPs) in genes involved in apoptotic pathways may modulate cellular AC in response to DNA damage. To f...