Adaptive Evolution Hotspots at the GC-Extremes of the Human Genome: Evidence for Two Functionally Distinct Pathways of Positive Selection [0.03%]
人类基因组中GC极端的适应性进化热点：两条正向选择的功能特异途径的证据
Clara S M Tang,Richard J Epstein
Clara S M Tang
We recently reported that the human genome is ''splitting" into two gene subgroups characterised by polarised GC content (Tang et al, 2007), and that such evolutionary change may be accelerated by programmed genetic instability (Zhao et al,...
Protein Bioinformatics Infrastructure for the Integration and Analysis of Multiple High-Throughput "omics" Data [0.03%]
整合和分析多种高通量“组学”数据的蛋白质生物信息学基础设施
Chuming Chen,Peter B McGarvey,Hongzhan Huang et al.
Chuming Chen et al.
High-throughput "omics" technologies bring new opportunities for biological and biomedical researchers to ask complex questions and gain new scientific insights. However, the voluminous, complex, and context-dependent data being maintained ...
Jing Wu
Jing Wu
Proposed is a procedure to test whether a genomic sequence contains coding DNA, called a coding potential region. The procedure tests the coding potential of conserved short genomic sequence, in which the assumptions on the probability mode...
Network Properties for Ranking Predicted miRNA Targets in Breast Cancer [0.03%]
网络属性在乳腺癌中用于预测miRNA靶基因的排名
Jörg Linde,Björn Olsson,Zelmina Lubovac
Jörg Linde
MicroRNAs control the expression of their target genes by translational repression and transcriptional cleavage. They are involved in various biological processes including development and progression of cancer. To uncover the biological ro...
Nirmalya Bandyopadhyay,Tamer Kahveci,Steve Goodison et al.
Nirmalya Bandyopadhyay et al.
Classification of cancers based on gene expressions produces better accuracy when compared to that of the clinical markers. Feature selection improves the accuracy of these classification algorithms by reducing the chance of overfitting tha...
Chi-Ruei Huang,Szecheng J Lo
Chi-Ruei Huang
Human hepatitis delta virus (HDV) is the smallest RNA virus in genome. HDV genome is divided into a viroid-like sequence and a protein-coding sequence which could have originated from different resources and the HDV genome was eventually co...
Accurate and scalable techniques for the complex/pathway membership problem in protein networks [0.03%]
蛋白质网络中复杂/通路隶属问题的精确而可扩展的技术
Orhan Camoğlu,Tolga Can,Ambuj K Singh
Orhan Camoğlu
A protein network shows physical interactions as well as functional associations. An important usage of such networks is to discover unknown members of partially known complexes and pathways. A number of methods exist for such analyses, and...
Recent bioinformatics advances in the analysis of high throughput flow cytometry data [0.03%]
高通量流式细胞数据分析的最新生物信息学进展
Raphael Gottardo,Ryan R Brinkman,George Luta et al.
Raphael Gottardo et al.
Algorithmic assessment of vaccine-induced selective pressure and its implications on future vaccine candidates [0.03%]
算法评估疫苗诱导的选择性压力及其对未来候选疫苗的影响
Mones S Abu-Asab,Majid Laassri,Hakima Amri
Mones S Abu-Asab
Posttrial assessment of a vaccine's selective pressure on infecting strains may be realized through a bioinformatic tool such as parsimony phylogenetic analysis. Following a failed gonococcal pilus vaccine trial of Neisseria gonorrhoeae, we...
Synonymous codon usage analysis of thirty two mycobacteriophage genomes [0.03%]
三十-two个结核杆状病毒基因组的同义密码子使用分析
Sameer Hassan,Vasantha Mahalingam,Vanaja Kumar
Sameer Hassan
Synonymous codon usage of protein coding genes of thirty two completely sequenced mycobacteriophage genomes was studied using multivariate statistical analysis. One of the major factors influencing codon usage is identified to be compositio...