A signal processing method to explore similarity in protein flexibility [0.03%]
一种用于探索蛋白质灵活性相似性的信号处理方法
Simina Vasilache,Nazanin Mirshahi,Soo-Yeon Ji et al.
Simina Vasilache et al.
Understanding mechanisms of protein flexibility is of great importance to structural biology. The ability to detect similarities between proteins and their patterns is vital in discovering new information about unknown protein functions. A ...
Laurent Noé,Marta Gîrdea,Gregory Kucherov
Laurent Noé
The advent of high-throughput sequencing technologies constituted a major advance in genomic studies, offering new prospects in a wide range of applications.We propose a rigorous and flexible algorithmic solution to mapping SOLiD color-spac...
Prediction of carbohydrate-binding proteins from sequences using support vector machines [0.03%]
利用支持向量机从序列预测糖链结合蛋白
Seizi Someya,Masanori Kakuta,Mizuki Morita et al.
Seizi Someya et al.
Carbohydrate-binding proteins are proteins that can interact with sugar chains but do not modify them. They are involved in many physiological functions, and we have developed a method for predicting them from their amino acid sequences. Ou...
Applying small-scale DNA signatures as an aid in assembling soybean chromosome sequences [0.03%]
应用小规模DNA特异序列表达体系以辅助组装大豆染色体序列
Myron Peto,David M Grant,Randy C Shoemaker et al.
Myron Peto et al.
Previous work has established a genomic signature based on relative counts of the 16 possible dinucleotides. Until now, it has been generally accepted that the dinucleotide signature is characteristic of a genome and is relatively homogeneo...
Marco Grzegorcyzk,Dirk Husmeier,Jörg Rahnenführer
Marco Grzegorcyzk
An important objective in systems biology is to infer gene regulatory networks from postgenomic data, and dynamic Bayesian networks have been widely applied as a popular tool to this end. The standard approach for nondiscretised data is res...
PROCARB: A Database of Known and Modelled Carbohydrate-Binding Protein Structures with Sequence-Based Prediction Tools [0.03%]
PROCARB：一个已知和建模的糖类结合蛋白质结构及其序列基础预测工具的数据库
Adeel Malik,Ahmad Firoz,Vivekanand Jha et al.
Adeel Malik et al.
Understanding of the three-dimensional structures of proteins that interact with carbohydrates covalently (glycoproteins) as well as noncovalently (protein-carbohydrate complexes) is essential to many biological processes and plays a signif...
A Comprehensive Study of Progressive Cytogenetic Alterations in Clear Cell Renal Cell Carcinoma and a New Model for ccRCC Tumorigenesis and Progression [0.03%]
透明细胞肾细胞癌的染色体渐进性改变的全面研究及ccRCC肿瘤发生和发展的新模型
Zhongfa Zhang,Bill Wondergem,Karl Dykema
Zhongfa Zhang
We present a comprehensive study of cytogenetic alterations that occur during the progression of clear cell renal cell carcinoma (ccRCC). We used high-density high-throughput Affymetrix 100 K SNP arrays to obtain the whole genome SNP copy n...
Finding biomarker signatures in pooled sample designs: a simulation framework for methodological comparisons [0.03%]
寻找生物标志物特征的混合样本设计：一种用于方法比较的模拟框架
Anna Telaar,Gerd Nürnberg,Dirk Repsilber
Anna Telaar
Detection of discriminating patterns in gene expression data can be accomplished by using various methods of statistical learning. It has been proposed that sample pooling in this context would have negative effects; however, pooling cannot...
Omar Gaci
Omar Gaci
We represent proteins by amino acid interaction networks. This is a graph whose vertices are the proteins amino acids and whose edges are the interactions between them. Once we have compared this type of graphs to the general model of scale...
EREM: Parameter Estimation and Ancestral Reconstruction by Expectation-Maximization Algorithm for a Probabilistic Model of Genomic Binary Characters Evolution [0.03%]
基于概率模型的基因组二元字符演化的期望最大化算法参数估计和祖先重建
Liran Carmel,Yuri I Wolf,Igor B Rogozin et al.
Liran Carmel et al.
Evolutionary binary characters are features of species or genes, indicating the absence (value zero) or presence (value one) of some property. Examples include eukaryotic gene architecture (the presence or absence of an intron in a particul...