A topology-based metric for measuring term similarity in the gene ontology [0.03%]
一种基于拓扑结构的本体术语相似度计算方法
Gaston K Mazandu,Nicola J Mulder
Gaston K Mazandu
The wide coverage and biological relevance of the Gene Ontology (GO), confirmed through its successful use in protein function prediction, have led to the growth in its popularity. In order to exploit the extent of biological knowledge that...
Neutropenia Prediction Based on First-Cycle Blood Counts Using a FOS-3NN Classifier [0.03%]
基于第一个周期血液计数的中性粒细胞减少预测的FOS-3NN分类器
Elize A Shirdel,Michael J Korenberg,Yolanda Madarnas
Elize A Shirdel
Background. Delivery of full doses of adjuvant chemotherapy on schedule is key to optimal breast cancer outcomes. Neutropenia is a serious complication of chemotherapy and a common barrier to this goal, leading to dose reductions or delays ...
Pedro Fernandes,Pooja Jain,Catarina Moita
Pedro Fernandes
Bioinformatics, for its very nature, is devoted to a set of targets that constantly evolve. Training is probably the best response to the constant need for the acquisition of bioinformatics skills. It is interesting to assess the effects of...
Structural Basis for Species Selectivity in the HIV-1 gp120-CD4 Interaction: Restoring Affinity to gp120 in Murine CD4 Mimetic Peptides [0.03%]
HIV-1 gp120与人源CD4相互作用的种属特异性机理研究：通过模拟肽恢复gp120的人源CD4亲和力
Kristin Kassler,Julia Meier,Jutta Eichler et al.
Kristin Kassler et al.
The first step of HIV-1 infection involves interaction between the viral glycoprotein gp120 and the human cellular receptor CD4. Inhibition of the gp120-CD4 interaction represents an attractive strategy to block HIV-1 infection. In an attem...
Inferring Biological Mechanisms by Data-Based Mathematical Modelling: Compartment-Specific Gene Activation during Sporulation in Bacillus subtilis as a Test Case [0.03%]
基于数据的数学建模推断生物机制：以芽孢杆菌（Bacillus subtilis）孢子形成过程中的隔室特异性基因活化为例测试模型
Dagmar Iber
Dagmar Iber
Biological functionality arises from the complex interactions of simple components. Emerging behaviour is difficult to recognize with verbal models alone, and mathematical approaches are important. Even few interacting components can give r...
Zheng Yuan,Jinhong Shi,Wenjun Lin et al.
Zheng Yuan et al.
For high-resolution tandem mass spectra, the determination of monoisotopic masses of fragment ions plays a key role in the subsequent peptide and protein identification. In this paper, we present a new algorithm for deisotoping the bottom-u...
Malte Brinkmeyer,Thasso Griebel,Sebastian Böcker
Malte Brinkmeyer
Supertree methods allow to reconstruct large phylogenetic trees by combining smaller trees with overlapping leaf sets into one, more comprehensive supertree. The most commonly used supertree method, matrix representation with parsimony (MRP...
GenSensor Suite: A Web-Based Tool for the Analysis of Gene and Protein Interactions, Pathways, and Regulation [0.03%]
GenSensor套装：分析基因和蛋白质相互作用、通路以及调控的网络工具套件
Mark Gosink,Sawsan Khuri,Camilo Valdes et al.
Mark Gosink et al.
The GenSensor Suite consists of four web tools for elucidating relationships among genes and proteins. GenPath results show which biochemical, regulatory, or other gene set categories are over- or under-represented in an input list compared...
Generation and Analysis of Large-Scale Data-Driven Mycobacterium tuberculosis Functional Networks for Drug Target Identification [0.03%]
基于大数据的结核杆菌功能网络的构建及药物靶点预测研究
Gaston K Mazandu,Nicola J Mulder
Gaston K Mazandu
Technological developments in large-scale biological experiments, coupled with bioinformatics tools, have opened the doors to computational approaches for the global analysis of whole genomes. This has provided the opportunity to look at ge...
An integrated framework to model cellular phenotype as a component of biochemical networks [0.03%]
一个综合框架 将细胞表型作为生化网络的组成部分予以描述
Michael Gormley,Viswanadha U Akella,Judy N Quong et al.
Michael Gormley et al.
Identification of regulatory molecules in signaling pathways is critical for understanding cellular behavior. Given the complexity of the transcriptional gene network, the relationship between molecular expression and phenotype is difficult...