J Paul Brooks,William P Burns,Stephen S Fong et al.
J Paul Brooks et al.
Constraint-based metabolic models are currently the most comprehensive system-wide models of cellular metabolism. Several challenges arise when building an in silico constraint-based model of an organism that need to be addressed before flu...
Producing high-accuracy lattice models from protein atomic coordinates including side chains [0.03%]
包括侧链的从原子坐标生成高精度晶格模型蛋白质
Martin Mann,Rhodri Saunders,Cameron Smith et al.
Martin Mann et al.
Lattice models are a common abstraction used in the study of protein structure, folding, and refinement. They are advantageous because the discretisation of space can make extensive protein evaluations computationally feasible. Various appr...
Gaetano Pierro
Gaetano Pierro
The nucleotide sequences complexity in chromosome 3 of Caenorhabditis elegans (C. elegans) is studied. The complexity of these sequences is compared with some random sequences. Moreover, by using some parameters related to complexity such a...
Detecting cancer outlier genes with potential rearrangement using gene expression data and biological networks [0.03%]
基于基因表达谱和生物网络的癌症异常基因检测算法
Mohammed Alshalalfa,Tarek A Bismar,Reda Alhajj
Mohammed Alshalalfa
Gene alterations are a major component of the landscape of tumor genomes. To assess the significance of these alterations in the development of prostate cancer, it is necessary to identify these alterations and analyze them from systems bio...
Literature retrieval and mining in bioinformatics: state of the art and challenges [0.03%]
生物信息学中的文献检索与挖掘：现状和挑战
Andrea Manconi,Eloisa Vargiu,Giuliano Armano et al.
Andrea Manconi et al.
The world has widely changed in terms of communicating, acquiring, and storing information. Hundreds of millions of people are involved in information retrieval tasks on a daily basis, in particular while using a Web search engine or search...
Exploring Biomolecular Literature with EVEX: Connecting Genes through Events, Homology, and Indirect Associations [0.03%]
利用EVEX探索生物分子文献：通过事件、同源性和间接关联连接基因
Sofie Van Landeghem,Kai Hakala,Samuel Rönnqvist et al.
Sofie Van Landeghem et al.
Technological advancements in the field of genetics have led not only to an abundance of experimental data, but also caused an exponential increase of the number of published biomolecular studies. Text mining is widely accepted as a promisi...
BioEve Search: A Novel Framework to Facilitate Interactive Literature Search [0.03%]
BioEve搜索：一种促进交互式文献检索的新框架
Syed Toufeeq Ahmed,Hasan Davulcu,Sukru Tikves et al.
Syed Toufeeq Ahmed et al.
Background. Recent advances in computational and biological methods in last two decades have remarkably changed the scale of biomedical research and with it began the unprecedented growth in both the production of biomedical data and amount...
Maximum Recommended Dosage of Lithium for Pregnant Women Based on a PBPK Model for Lithium Absorption [0.03%]
基于锂吸收的PBPK模型推荐怀孕妇女的最大锂摄取剂量上限值分析
Scott Horton,Amalie Tuerk,Daniel Cook et al.
Scott Horton et al.
Treatment of bipolar disorder with lithium therapy during pregnancy is a medical challenge. Bipolar disorder is more prevalent in women and its onset is often concurrent with peak reproductive age. Treatment typically involves administratio...
Anne E Thessen,Hong Cui,Dmitry Mozzherin
Anne E Thessen
Centuries of biological knowledge are contained in the massive body of scientific literature, written for human-readability but too big for any one person to consume. Large-scale mining of information from the literature is necessary if bio...
BRASERO: A Resource for Benchmarking RNA Secondary Structure Comparison Algorithms [0.03%]
Brasero：RNA二级结构比较算法的评测资源
Julien Allali,Cédric Saule,Cédric Chauve et al.
Julien Allali et al.
The pairwise comparison of RNA secondary structures is a fundamental problem, with direct application in mining databases for annotating putative noncoding RNA candidates in newly sequenced genomes. An increasing number of software tools ar...