Gumpeny Ramachandra Sridhar,Padmanabhuni Venkata Nageswara Rao,Dowluru Svgk Kaladhar et al.
Gumpeny Ramachandra Sridhar et al.
Background. HNF-1a is a transcription factor that regulates glucose metabolism by expression in various tissues. Aim. To dock potential ligands of HNF-1a using docking software in silico. Methods. We performed in silico studies using HNF-1a...
Anna Divoli,Preslav Nakov,Marti A Hearst
Anna Divoli
Recent years have shown a gradual shift in the content of biomedical publications that is freely accessible, from titles and abstracts to full text. This has enabled new forms of automatic text analysis and has given rise to some interestin...
Fatemeh Safara,Shyamala Doraisamy,Azreen Azman et al.
Fatemeh Safara et al.
Heart murmurs are the first signs of cardiac valve disorders. Several studies have been conducted in recent years to automatically differentiate normal heart sounds, from heart sounds with murmurs using various types of audio features. Entr...
Mohamed Amine Fnaiech,Hazem Nounou,Mohamed Nounou et al.
Mohamed Amine Fnaiech et al.
The problems of modeling and intervention of biological phenomena have captured the interest of many researchers in the past few decades. The aim of the therapeutic intervention strategies is to move an undesirable state of a diseased netwo...
On the meaning of affinity limits in B-cell epitope prediction for antipeptide antibody-mediated immunity [0.03%]
基于抗肽抗体介导免疫的B细胞表位预测中亲和力界限的意义探讨
Salvador Eugenio C Caoili
Salvador Eugenio C Caoili
B-cell epitope prediction aims to aid the design of peptide-based immunogens (e.g., vaccines) for eliciting antipeptide antibodies that protect against disease, but such antibodies fail to confer protection and even promote disease if they ...
MicroRNA Response Elements-Mediated miRNA-miRNA Interactions in Prostate Cancer [0.03%]
前列腺癌中基于微小核糖核酸反应原件的微小核糖核酸-微小核糖核酸相互作用
Mohammed Alshalalfa
Mohammed Alshalalfa
The cell is a highly organized system of interacting molecules including proteins, mRNAs, and miRNAs. Analyzing the cell from a systems perspective by integrating different types of data helps revealing the complexity of diseases. Although ...
Application of an integrative computational framework in trancriptomic data of atherosclerotic mice suggests numerous molecular players [0.03%]
整合计算框架在动脉粥样硬化小鼠转录组数据中的应用揭示了多个分子参与者
Olga Papadodima,Allan Sirsjö,Fragiskos N Kolisis et al.
Olga Papadodima et al.
Atherosclerosis is a multifactorial disease involving a lot of genes and proteins recruited throughout its manifestation. The present study aims to exploit bioinformatic tools in order to analyze microarray data of atherosclerotic aortic le...
Flux Analysis of the Trypanosoma brucei Glycolysis Based on a Multiobjective-Criteria Bioinformatic Approach [0.03%]
基于多目标生物信息学方法的布氏锥虫糖酵解通量分析
Amine Ghozlane,Frédéric Bringaud,Hayssam Soueidan et al.
Amine Ghozlane et al.
Trypanosoma brucei is a protozoan parasite of major of interest in discovering new genes for drug targets. This parasite alternates its life cycle between the mammal host(s) (bloodstream form) and the insect vector (procyclic form), with tw...
CMD: A Database to Store the Bonding States of Cysteine Motifs with Secondary Structures [0.03%]
CMD：一个用于存放半胱氨酸基元与二级结构结合状态的数据库
Hamed Bostan,Naomie Salim,Zeti Azura Hussein et al.
Hamed Bostan et al.
Computational approaches to the disulphide bonding state and its connectivity pattern prediction are based on various descriptors. One descriptor is the amino acid sequence motifs flanking the cysteine residue motifs. Despite the existence ...
A high-throughput computational framework for identifying significant copy number aberrations from array comparative genomic hybridisation data [0.03%]
一种计算框架用于从DNA微阵列 Comparative Genomic Hybridization (CGH) 数据中识别显著拷贝数异常
Ian Roberts,Stephanie A Carter,Cinzia G Scarpini et al.
Ian Roberts et al.
Reliable identification of copy number aberrations (CNA) from comparative genomic hybridization data would be improved by the availability of a generalised method for processing large datasets. To this end, we developed swatCGH, a data anal...