Effects of grape seed extract, vitamin C, and vitamin e on ethanol- and aspirin-induced ulcers [0.03%]
葡萄籽提取物、维生素C和维生素E对乙醇和阿司匹林所致溃疡的影响
Vivian Molina Cuevas,Yazmín Ravelo Calzado,Yohani Pérez Guerra et al.
Vivian Molina Cuevas et al.
Effects of GSE and vitamins C and E on aspirin- and ethanol-induced gastric ulcer and associated increases of lipid peroxidation in rats were compared. Two experiments were conducted. Rats were randomized into eight groups: a negative contr...
A Comparison of the α2/3/5 Selective Positive Allosteric Modulators L-838,417 and TPA023 in Preclinical Models of Inflammatory and Neuropathic Pain [0.03%]
α2/3/5 选择性正向变构调节剂L-838，417和TPA023在炎性和神经病理性疼痛模型中的比较研究
Sarah Nickolls,Hannah Mace,Rebecca Fish et al.
Sarah Nickolls et al.
GABA(A) receptors containing α2/3 subunits are current targets in the battle to develop new pain medications, as they are expressed in the spinal cord where increasing inhibitory drive should result in analgesia. However, this approach is ...
Central and Peripheral GABA(A) Receptor Regulation of the Heart Rate Depends on the Conscious State of the Animal [0.03%]
中枢和外周GABAA受体对心率的调节依赖于动物的意识状态
Bo Hjorth Bentzen,Morten Grunnet
Bo Hjorth Bentzen
Intuitively one might expect that activation of GABAergic inhibitory neurons results in bradycardia. In conscious animals the opposite effect is however observed. GABAergic neurons in nucleus ambiguus hold the ability to control the activit...
Vaishali D Shewale,Tushar A Deshmukh,Liladhar S Patil et al.
Vaishali D Shewale et al.
The present work was to evaluate the anti-inflammatory activity of Delonix regia leaves (Family: Caesalpiniaceae). The powder of Delonix regia leaves was subjected to extraction with ethanol in soxhlet extractor. The ethanol extract after p...
Neurosteroid Binding Sites on the GABA(A) Receptor Complex as Novel Targets for Therapeutics to Reduce Alcohol Abuse and Dependence [0.03%]
靶向神经类固醇受体以减少酒精滥用和依赖的新疗法
Mary W Hulin,Russell J Amato,Johnny R Porter et al.
Mary W Hulin et al.
Despite the prevalence of alcohol abuse and dependence in the US and Europe, there are only five approved pharmacotherapies for alcohol dependence. Moreover, these pharmacotherapeutic options have limited clinical utility. The purpose of th...
Takayuki Matsumoto,Rita C Tostes,R Clinton Webb
Takayuki Matsumoto
The endothelium plays a pivotal role in vascular homeostasis, and endothelial dysfunction is a major feature of cardiovascular diseases, such as arterial hypertension, atherosclerosis, and diabetes. Recently, uridine adenosine tetraphosphat...
Chronic Treatment with a Promnesiant GABA-A α5-Selective Inverse Agonist Increases Immediate Early Genes Expression during Memory Processing in Mice and Rectifies Their Expression Levels in a Down Syndrome Mouse Model [0.03%]
一种长效促记忆的GABA-Aα5选择性拮抗剂可增加小鼠在记忆处理过程中立早基因表达并改善唐氏综合症动物模型中的其表达水平
J Braudeau,L Dauphinot,A Duchon et al.
J Braudeau et al.
Decrease of GABAergic transmission has been proposed to improve memory functions. Indeed, inverse agonists selective for α5 GABA-A-benzodiazepine receptors (α5IA) have promnesiant activity. Interestingly, we have recently shown that α5IA...
Dysregulation of iron metabolism in Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis [0.03%]
阿尔茨海默病、帕金森病和肌萎缩侧索硬化症中铁代谢失调
Satoru Oshiro,Masaki S Morioka,Masataka Kikuchi
Satoru Oshiro
Dysregulation of iron metabolism has been observed in patients with neurodegenerative diseases (NDs). Utilization of several importers and exporters for iron transport in brain cells helps maintain iron homeostasis. Dysregulation of iron ho...
Varsha Shukla,Santosh K Mishra,Harish C Pant
Varsha Shukla
It has been demonstrated that oxidative stress has a ubiquitous role in neurodegenerative diseases. Major source of oxidative stress due to reactive oxygen species (ROS) is related to mitochondria as an endogenous source. Although there is ...
Augmentation of Tonic GABA(A) Inhibition in Absence Epilepsy: Therapeutic Value of Inverse Agonists at Extrasynaptic GABA(A) Receptors [0.03%]
增強原発性 generalised 惡性巴金森症的全胺基酸抑制作用：外突觸 GABA(A) 接受器之反向活化劑的治療價值
Adam C Errington,David W Cope,Vincenzo Crunelli
Adam C Errington
It is well established that impaired GABAergic inhibition within neuronal networks can lead to hypersynchronous firing patterns that are the typical cellular hallmark of convulsive epileptic seizures. However, recent findings have highlight...