Mannan-binding lectin levels and activity are not altered in atopic dermatitis patients with a history of eczema herpeticum [0.03%]
自身敏感性皮炎伴带状疱疹患者的甘露聚糖结合凝集素水平及活性未发生变化
Kemp W Bundy,Laura Y McGirt,Lora G Bankova et al.
Kemp W Bundy et al.
Background. Eczema herpeticum (EH) is a potentially serious, systemic complication in subjects with atopic dermatitis (AD) caused by herpes simplex virus (HSV). The innate immune dysregulation that predisposes these subjects to cutaneous vi...
Ipilimumab, a promising immunotherapy with increased overall survival in metastatic melanoma? [0.03%]
伊匹单抗——有望提高转移性黑色素瘤总生存率的免疫疗法吗？
Gérald E Piérard,François Aubin,Philippe Humbert
Gérald E Piérard
Malignant melanoma (MM) is one of the most aggressive skin cancer. The therapeutic options remain limited for advanced MM, and those directed to the neoplastic cells have not brought major survival advantage so far. Immunotherapy is another...
Marie-Annick Reginster,Claudine Pierard-Franchimont,Gérald E Piérard et al.
Marie-Annick Reginster et al.
At present, immunohistochemistry is taken for granted in the establishment of malignant melanoma (MM) diagnosis. In recent years, molecular diagnosis in dermatopathology has benefited from a vast array of advances in the fields of genomics ...
RAS/RAF/MEK/ERK and PI3K/PTEN/AKT Signaling in Malignant Melanoma Progression and Therapy [0.03%]
恶性黑色素瘤发生发展中RAS/RAF/MEK/ERK和PI3K/PTEN/AKT信号通路的作用及治疗策略
Ichiro Yajima,Mayuko Y Kumasaka,Nguyen Dinh Thang et al.
Ichiro Yajima et al.
Cutaneous malignant melanoma is one of the most serious skin cancers and is highly invasive and markedly resistant to conventional therapy. Melanomagenesis is initially triggered by environmental agents including ultraviolet (UV), which ind...
Review of diagnostic imaging modalities for the surveillance of melanoma patients [0.03%]
黑色素瘤患者诊断影像检查方式的回顾性分析
Yan Xing,Kate D Cromwell,Janice N Cormier
Yan Xing
As melanoma survival rates continue to increase, optimal surveillance strategies for recurrences are needed, as are effective imaging modalities. Therefore, we performed a meta-analysis to evaluate the current state of imaging modalities fo...
Amniotic membrane as a scaffold for melanocyte transplantation in patients with stable vitiligo [0.03%]
羊膜作为黑素细胞移植治疗稳定期白癜风受体的支架作用研究
Pedro Redondo,Ana Giménez de Azcarate,Laura Marqués et al.
Pedro Redondo et al.
Vitiligo is an acquired skin disease that significantly impacts the quality of life of patients. Medical treatment of vitiligo includes the use of melanocyte transplant, but the results are variable. We have treated 4 patients with either f...
Adriana Taveira da Cruz,Miriam Galvonas Jasiulionis
Adriana Taveira da Cruz
miRNAs are non-coding RNAs that bind to mRNA targets and disturb their stability and/or translation, thus acting in gene posttranscriptional regulation. It is predicted that over 30% of mRNAs are regulated by miRNAs. Therefore these molecul...
A Double-Blind, Randomized Clinical Trial of Niacinamide 4% versus Hydroquinone 4% in the Treatment of Melasma [0.03%]
烟酰胺乳膏治疗黄褐斑的双盲随机对照研究
Josefina Navarrete-Solís,Juan Pablo Castanedo-Cázares,Bertha Torres-Álvarez et al.
Josefina Navarrete-Solís et al.
Background. Multiple modalities have been used in the treatment of melasma with variable success. Niacinamide has anti-inflammatory properties and is able to decrease the transfer of melanosomes. Objective. To evaluate the therapeutic effec...
Naoki Oiso,Tamio Suzuki,Kazuyoshi Fukai et al.
Naoki Oiso et al.
Nonsegmental vitiligo is a depigmented skin disorder showing acquired, progressive, and depigmented lesions of the skin, mucosa, and hair. It is believed to be caused mainly by the autoimmune loss of melanocytes from the involved areas. It ...
Z-plasty made simple [0.03%]
简化的Z字成形术
Sumaira Z Aasi
Sumaira Z Aasi
A Z-plasty is a critical and reliable technique that is useful for scar revisions and correction of free margin distortion. A Z-plasty can help lengthen a contracted scar, change the direction of a scar so that it is better aligned with the...