Subcutaneous Sarcoidosis during Pegylated Interferon Alfa and Ribavirin Treatment for Chronic Hepatitis C [0.03%]
聚乙二醇干扰素α和利巴韦林治疗慢性丙型肝炎时出现皮下结节病
R Rodríguez-Lojo,M Almagro,J M Barja et al.
R Rodríguez-Lojo et al.
Interferon is used to treat hepatitis C virus infection and its cutaneous side effects are well known. Recently, interferon-induced sarcoidosis has been reported. We report a new case of sarcoidosis during pegylated interferon alfa and riba...
A new perspective on intercalated disc organization: implications for heart disease [0.03%]
从新的视角看待缝隙连接的组织：对心脏病的影响
Jifen Li,Glenn L Radice
Jifen Li
Adherens junctions and desmosomes are intercellular adhesive junctions and essential for the morphogenesis, differentiation, and maintenance of tissues that are subjected to high mechanical stress, including heart and skin. The different ju...
Mario Cezar Pires,João Mauricio Martins,F Montealegre et al.
Mario Cezar Pires et al.
The topical immunotherapy is used to treat alopecia areata and recalcitrant warts since the 1970s. Diphencyprone is a contact sensitizer used to treat dermatological conditions resulting from as altered immunological state, such as extensiv...
Gerda van der Wier,Hendri H Pas,Marcel F Jonkman
Gerda van der Wier
Pemphigus is a chronic mucocutaneous autoimmune bullous disease that is characterized by loss of cell-cell contact in skin and/or mucous membranes. Past research has successfully identified desmosomes as immunological targets and has demons...
Steffen Neuber,Mario Mühmer,Denise Wratten et al.
Steffen Neuber et al.
Three related proteins of the plakophilin family (PKP1_3) have been identified as junctional proteins that are essential for the formation and stabilization of desmosomal cell contacts. Failure of PKP expression can have fatal effects on de...
Ricardo Romiti,Mauricio Levy Neto,Marcello Menta Simonsen Nico
Ricardo Romiti
Onset is usually sudden with symmetrical articular involvement of both small and large joints, occurrence of solid skin nodules, and rapid progression. Treatment is generally unrewarding. Here we report a severe and disabling case of FR res...
A M Manganoni,C Farisoglio,S Bassissi et al.
A M Manganoni et al.
Background. The clinical presentation of desmoplastic melanoma is often challenging. We report the experience of the Melanoma Unit of Spedali Civili University Hospital of Brescia, Italy. Method. Study subjects were drawn from 1770 patients...
Richard Baker,Fulvio Urso-Baiarda,Claire Linge et al.
Richard Baker et al.
Cutaneous scarring can cause patients symptoms ranging from the psychological to physical pain. Although the process of normal scarring is well described the ultimate cause of pathological scarring remains unknown. Similarly, exactly how ea...
Progressive macular hypomelanosis: a rarely diagnosed hypopigmentation in Caucasians [0.03%]
进行性黄斑减色症：一种罕见的白种人色素减少症状
Sven Neynaber,Christina Kirschner,Stefanie Kamann et al.
Sven Neynaber et al.
A 35-year-old woman who developed whitish macules on trunk and limbs at 12 years of age and observed a remarkable increase of the hypopigmentated lesions after her pregnancies at ages 29 and 32 years. Because of the highly characteristic cl...
An experimental in vivo model to characterize "heavy legs" symptom in topical formulations [0.03%]
一种表征外用药品中“沉重的腿部”症状的体内实验模型
Pedro Contreiras Pinto,Luís Monteiro Rodrigues
Pedro Contreiras Pinto
The "Heavy legs" symptom is regarded as an early expression of chronic venous failure, estimated to affect 40% of the population in developing countries. A new methodology is proposed to approach the "tired or heavy legs" symptom. Seven fem...