YunFeng Cheng,MinYong Li,ShaoRu Wang et al.
YunFeng Cheng et al.
Carbohydrates are considered as one of the most important classes of biomarkers for cell types, disease states, protein functions, and developmental states. Carbohydrate "binders" that can specifically recognize a carbohydrate biomarker can...
Engineering a customized nanodrug delivery system at the cellular level for targeted cancer therapy [0.03%]
细胞水平的纳米药物传输系统的设计及其在癌症治疗中的应用
Jin Li,Liping Qiu,Sitao Xie et al.
Jin Li et al.
Drug administration customized to individual cells could intrinsically address cancer heterogeneity and provide a safe and effective method for delivering personalized treatment. To accomplish this, we developed a smart nanodrug delivery sy...
Onel Buket,Lin Clement,Yang DanZhou
Onel Buket
G-quadruplex secondary structures are four-stranded globular nucleic acid structures form in the specific DNA and RNA G-rich sequences with biological significance such as human telomeres, oncogene-promoter regions, replication initiation s...
Kaur Manindar,Huang Zhen
Kaur Manindar
We have developed a simple method to synthesize 6-seleno-2'-deoxyguanosine (SedG) by selectively replacing the 6-oxygen atom with selenium. This selenium-atom-specific modification (SAM) alters the optical properties of the naturally occurr...
Synthetic biodegradable functional polymers for tissue engineering: a brief review [0.03%]
组织工程用合成生物可降解功能高分子材料研究进展综述
Guo BaoLin,Peter X Ma
Guo BaoLin
Scaffolds play a crucial role in tissue engineering. Biodegradable polymers with great processing flexibility are the predominant scaffolding materials. Synthetic biodegradable polymers with well-defined structure and without immunological ...
Tightening up the structure, lighting up the pathway: Application of molecular constraints and light to manipulate protein folding, self-assembly and function [0.03%]
巧设计与添光亮：利用分子约束和光照调控蛋白质折叠、自组装及功能
Beatrice N Markiewicz,Robert M Culik,Feng Gai
Beatrice N Markiewicz
Chemical cross-linking provides an effective avenue to reduce the conformational entropy of polypeptide chains and hence has become a popular method to induce or force structural formation in peptides and proteins. Recently, other types of ...
Understanding Protein Palmitoylation: Biological Significance and Enzymology [0.03%]
蛋白质棕榈酰化研究：生物功能与酶学机制
Xiaomu Guan,Carol A Fierke
Xiaomu Guan
Protein palmitoylation is a widespread lipid modification in which one or more cysteine thiols on a substrate protein are modified to form a thioester with a palmitoyl group. This lipid modification is readily reversible; a feature of prote...
Synthesis of novel di-Se-containing thymidine and Se-DNAs for structure and function studies [0.03%]
用于结构和功能研究的新型含二硒键脱氧胸腺嘧啶核苷及硒代DNA的合成
Zhang Wen,Hassan E Abdalla,Huang Zhen
Zhang Wen
The selenium derivatization of nucleic acids and nucleic acid-protein complexes has provided a powerful tool to solve phase problem in X-ray crystallography. Selenium atoms in the nucleotides can serve as fine scattering centers in crystal ...
Web search and data mining of natural products and their bioactivities in PubChem [0.03%]
PubChem中天然产物及其生物活性的网络检索与数据挖掘
Hao Ming,Cheng Tiejun,Wang Yanli et al.
Hao Ming et al.
Natural products, as major resources for drug discovery historically, are gaining more attentions recently due to the advancement in genomic sequencing and other technologies, which makes them attractive and amenable to drug candidate scree...
Jiali Gao
Jiali Gao
We describe a computational approach, incorporating quantum mechanics into enzyme kinetics modeling with a special emphasis on computation of kinetic isotope effects. Two aspects are highlighted: (1) the potential energy surface is represen...