Research progress in proteasome inhibitor resistance to multiple myeloma [0.03%]
蛋白酶体抑制剂抗多发性骨髓瘤的研究进展
Jiao Wu,Jing Liu
Jiao Wu
Multiple myeloma (MM) is a highly heterogeneous malignant plasma cell disease. Proteasome inhibitors (PIs) are the first line of medicine for MM. Bortezomib, ixazomib, and carfilzomib are also widely used for MM. Marizomib, oprozomib, and K...
Lihui Wang,Chenghui Huang
Lihui Wang
Over the past decade, immunotherapy has been shown to have antitumor activity in a variety of solid tumors, such as melanoma, renal cell carcinoma, and non-small cell lung cancer, keeping a lead in a new era of tumor immunotherapy. Colorect...
Yanpei Zhang,Shuqiao Yuan,Tuanjie Che et al.
Yanpei Zhang et al.
The prevalence of abnormal glucose and lipid metabolism and its relevant diseases has increased year by year, and it has become a problem that threatens human health. Therefore, finding a more effective way to prevent and treat diseases rel...
Correlation between coronary CTA - SYNTAX score and invasive coronary angiography - SYNTAX score [0.03%]
冠状动脉CTA-辛塔克斯评分与有创性冠状动脉造影-辛塔克斯评分的相关性研究
Ye Mo,Bo Xing
Ye Mo
It is important to evaluate the complex coronary artery disease in the diagnosis and treatment of coronary heart disease.The SYNTAX score based on invasive coronary angiography (ICA) (also referred to as ICA-SYNTAX score) plays a positive r...
Boyao Yu,Chunfan Xie,Siyang Yu et al.
Boyao Yu et al.
Atrial fibrillation (AF), a common arrhythmia that usually occurs in patients with heart disease, is one of the leading causes for mortality and disability worldwide. Current drug therapy for AF patients lacks sufficient efficacy and has si...
Research progress in apoptosis of vascular smooth muscle cells in atherosclerosis [0.03%]
动脉粥样硬化过程中血管平滑肌细胞凋亡的研究进展
Siqi Yang,Jian Wang,Lan Tong et al.
Siqi Yang et al.
Vascular smooth muscle cell (VSMC) is one of the main cell types in blood vessel wall, and the VSMC apoptosis is involved in the development of atherosclerosis (AS). In early AS, the apoptosis of VSMC is regarded as a compensatory mechanism...
Effect of continuous positive air pressure on cognitive impairment associated with obstructive sleep apnea [0.03%]
持续正压通气对阻塞性睡眠呼吸暂停相关认知障碍的影响
Ting Liu,Ruoyun Ouyang
Ting Liu
Obstructive sleep apnea (OSA) is a kind of sleep-related breathing disorder, involving multiple organs and systems, which can lead to cognitive impairment. At present, the pathophysiological mechanism of cognitive impairment related to OSA ...
Yimin Hu,Huiping Zhao,Wei Li et al.
Yimin Hu et al.
Objectives: Previous studies on brain MRI image segmentation, such as threshold method, boundary detection method, and region method did not achieve good performance in complex scenes. Based on the deep learning segmentat...
Early correction of coagulopathy reduces the 28 - day mortality in adult patients with large - area burns [0.03%]
早期纠正凝血功能障碍可降低大面积烧伤成年患者的28天死亡率
Kun Xiao,Fei Zhao,Xincheng Liao et al.
Kun Xiao et al.
Objectives: Coagulation dysfunction caused by large-area burns is an independent risk factor for the 28-day mortality of adult patients. However, whether early (48 hours after admission) correction of coagulopathy can red...
Surgical approach of laryngofissure combined with epiglottis valley in treating locally-advanced pyriform sinus carcinoma [0.03%]
喉裂瓣联合会厌谷皮瓣手术治疗局部晚期梨状窝癌
Ping Wu,Yaoyun Tang,Xing Fang et al.
Ping Wu et al.
Objectives: To evaluate feasibility and efficacy of surgical approach of laryngofissure combined with epiglottis valley in treating locally-advanced pyriform sinus carcinoma. ...