BTVT ameliorates offspring blood - brain barrier damage induced by prenatal and lactational neodymium oxide exposure via the gut - brain axis [0.03%]
BTVT通过肠-脑轴改善孕期和哺乳期暴露于氧化钕引起的后代血脑屏障损伤
Xiaoyan DU,Xiaocheng Gao,Jing Cao et al.
Xiaoyan DU et al.
Objectives: Exposure to rare earth elements (REEs) has been linked to various systemic diseases, but their impact on the offspring blood-brain barrier (BBB) via the gut-brain axis remains unclear. This study aims to inves...
Noggin alleviates neuropathic pain by regulating microglial polarization and remodeling iron homeostasis via a STAT3-dependent pathway [0.03%]
Noggin通过STAT3依赖性途径调节小胶质细胞极化和重塑铁稳态以缓解神经病理性疼痛
Wenjuan Zhang,Lin Yang,Ran Zhang
Wenjuan Zhang
Objectives: Pain sensitization, as a core feature of neuropathic pain (NP), is closely associated with inflammatory imbalance within the central nervous system. To investigate the effects of intrathecal injection of noggi...
EGR2 maintains neuropathic pain by promoting microglial phagocytosis [0.03%]
EGR2通过促进小胶质细胞吞噬作用维持神经病理性疼痛
Caiyun Xi,Jianxi Zhang,Zhifeng Huang et al.
Caiyun Xi et al.
Objectives: Neuropathic pain (NP) is one of the most common forms of chronic pain, yet current treatment options are limited in effectiveness. Peripheral nerve injury activates spinal microglia, altering their inflammator...
Astrocytes promote oligodendrocyte precursor cell proliferation via Cx47 - mediated regulation of exosome - derived CHI3L1 secretion [0.03%]
星形胶质细胞通过Cx47介导调节CHI3L1外泌体分泌促进少突胶质前体细胞增殖
Xiaoyan Zhang,Nannan Cheng,Yan Peng
Xiaoyan Zhang
Objectives: Neurodegenerative diseases are closely associated with myelin loss, and the proliferation and differentiation of oligodendrocyte precursor cells (OPCs) are crucial to remyelination. However, the regulatory mec...
Wanyun Ma,Liang Zhao,Wen Zhou
Wanyun Ma
Multiple myeloma (MM) is a common hematologic malignancy that originates from precursor conditions such as monoclonal gammopathy of undetermined significance (MGUS) and smoldering multiple myeloma (SMM). Identifying its risk factors is cruc...
Clinical significance of CD45 and CD200 expression in newly diagnosed multiple myeloma patients [0.03%]
CD45和CD200在新诊断多发性骨髓瘤患者中的临床意义
Xinyi Long,Jing Liu,Rong Hu et al.
Xinyi Long et al.
Objectives: Multiple myeloma (MM) is a hematologically malignant clonal plasma cell disease. This study aims to explore the association between immunophenotypes and prognosis in patients with MM, to determine whether the ...
Construction of a treatment response prediction model for multiple myeloma based on multi-omics and machine learning [0.03%]
基于多组学和机器学习的弥漫大B细胞淋巴瘤治疗反应预测模型构建
Xionghui Zhou,Rong Gui,Jing Liu et al.
Xionghui Zhou et al.
Objectives: Multiple myeloma (MM) is a hematologic malignancy characterized by clonal proliferation of plasma cells and remains incurable. Patients with primary refractory multiple myeloma (PRMM) show poor response to ini...
A prognostic model for multiple myeloma based on lipid metabolism related genes [0.03%]
基于脂质代谢相关基因的多发性骨髓瘤预后模型
Zhengjiang Li,Liang Zhao,Fangming Shi et al.
Zhengjiang Li et al.
Objectives: Multiple myeloma (MM) is a highly heterogeneous hematologic malignancy, with disease progression driven by cytogenetic abnormalities and a complex bone marrow microenvironment. This study aims to construct a p...
A case of mitochondrial encephalomyopathy remarkable presenting with refractory shock [0.03%]
一例线粒体脑肌病伴难治性休克的病例报告
Yang Liao,Daomiao Xu,Li Li
Yang Liao
Mitochondrial encephalomyopathy is a multisystemic metabolic disorder caused by mutations in mitochondrial or nuclear genes. It commonly presents with stroke-like episodes or myopathy as initial symptoms. This paper reports a young male pat...
Yuchun Yang,Xiaojie Zhang,Ti Chen
Yuchun Yang
In recent years, gut microbiota has been increasingly recognized as a key player in ethanol metabolism and the development of related diseases. On one hand, ethanol intake directly affects the gut, leading to significant alterations in micr...