Weiman Huang,Yujing Wang,Xidi Wang et al.
Weiman Huang et al.
Peptide-based drugs possess several advantages, including high specificity, low immunogenicity, minimal accumulation, and fewer drug-drug interactions, making them a novel and efficient therapeutic class for various diseases. In recent year...
Impact of muscle strength decline and exercise intervention on multimorbidity of chronic diseases in older adults [0.03%]
肌肉力量下降和运动干预对老年人慢性多发病的影响
Yajing Zhao,Peizhen Zhang
Yajing Zhao
Multimorbidity of chronic diseases is one of the most common health issues among older adults, and the resulting demand for long-term medical care and management imposes a considerable burden on healthcare systems. Muscle strength, a core i...
Psychological experiences of young end stage renal disease patients awaiting kidney transplantation: A qualitative study [0.03%]
年轻终末期肾病患者等待肾脏移植的心理体验：一项定性研究
Dian Liu,Huilan Xu,Zhihao Zhang et al.
Dian Liu et al.
Objectives: End stage renal disease (ESRD) is a major disease that seriously threatens the health of young people, and kidney transplantation is an effective treatment method to improve its prognosis.Young ESRD patients a...
Impact of remote follow-up under an intelligent medical collaboration model on health promotion and clinical outcomes in patients with urinary calculi [0.03%]
基于智能医联体模式的尿石症患者远程随访对健康促进及临床结局的影响研究
Yuting Yang,Fengyan Song,Jiacheng He et al.
Yuting Yang et al.
Objectives: Urinary calculi are characterized by a high recurrence rate, and patients' adherence to self-management after discharge directly affects health outcomes. Traditional offline follow-up models often face problem...
Mechanism by which mechanical stimulation regulates chondrocyte apoptosis and matrix metabolism via primary cilia to delay osteoarthritis progression [0.03%]
力学刺激通过主 cilium调节软骨细胞凋亡和基质代谢延缓骨关节炎进展的作用机制
Huixian Ling,Sha Wu,Ziyu Luo et al.
Huixian Ling et al.
Objectives: Osteoarthritis (OA) is one of the most common chronic degenerative diseases, with chondrocyte apoptosis and extracellular matrix (ECM) degradation as the major pathological changes. The mechanical stimulation ...
Effects of metformin on gut microbiota and short -/medium - chain fatty acids in high - fat diet rats [0.03%]
二甲双胍对高脂饮食大鼠肠道菌群及短链/中链脂肪酸的影响
Ying Shi,Lin Xing,Shanyu Wu et al.
Ying Shi et al.
Objectives: Recent evidence suggests that the gut may be a primary site of metformin action. However, studies on the effects of metformin on gut microbiota remain limited, and its impact on gut microbial metabolites such ...
Tripterygium wilfordii attenuates acute lung injury by regulating the differentiation and function of myeloid-derived suppressor cells [0.03%]
雷公藤抑制急性肺损伤的机制研究：调节髓系源性抑制细胞的分化及功能的作用
Lingyu Wei,Shu Tong,Meng&#x;er Wang et al.
Lingyu Wei et al.
Objectives: Acute lung injury (ALI) is an acute respiratory failure syndrome characterized by impaired gas exchange. Due to the lack of effective targeted drugs, it is associated with high mortality and poor prognosis. Tr...
O-GlcNAcylated YTHDF2 promotes bladder cancer progression by regulating the tumor suppressor gene PER1 via m6A modification [0.03%]
O-GlcNAc修饰的YTHDF2通过m6A修饰调控肿瘤抑制基因PER1促进膀胱癌进展
Li Wang,Da Ren,Zeqiang Cai et al.
Li Wang et al.
Objectives: Bladder cancer is a common malignancy with high incidence and poor prognosis. N6-methyladenosine (m6A) modification is widely involved in diverse physiological processes, among which the m6A recognition protei...
FTO - regulated m6A modification of pri - miR - 139 represses papillary thyroid carcinoma metastasis [0.03%]
FTO通过调节pri-miR-139的m6A修饰抑制乳头状甲状腺癌转移
Jiale Li,Ping Zhou,Juan DU et al.
Jiale Li et al.
Objectives: Increasing detection of low-risk papillary thyroid carcinoma (PTC) is associated with overdiagnosis and overtreatment. N6-methyladenosine (m6A)-mediated microRNA (miRNA) dysregulation plays a critical role in ...
Radiogenomics-based prediction of KRAS and EGFR gene mutation in non-small cell lung cancer patients [0.03%]
基于影像组学预测非小细胞肺癌患者KRAS和EGFR基因突变
Jianing Lin,Zhihang Yan,Longyu He et al.
Jianing Lin et al.
Objectives: Non-small cell lung cancer (NSCLC) is associated with poor prognosis, with 30% of patients diagnosed at an advanced stage. Mutations in the EGFR and KRAS genes are important prognostic factors for NSCLC, and t...