Comparison of the Effects of Pioglitazone versus Placebo when Given in Addition to Standard Insulin Treatment in Patients with Type 2 Diabetes Mellitus Requiring Hemodialysis: Results from the PIOren Study [0.03%]
胰岛素治疗基础上加用吡格列酮或安慰剂对2型糖尿病伴终末期肾病患者疗效对比：PIOren研究结果
Jan Galle,Werner Kleophas,Frank Dellanna et al.
Jan Galle et al.
Background: Patients with type 2 diabetes mellitus and advanced kidney disease are usually treated with insulin. However, the prolonged pharmacokinetic insulin profile in patients with delayed renal insulin elimination im...
Hyperglycemia and renal mass ablation synergistically augment albuminuria in the diabetic subtotally nephrectomized rat: implications for modeling diabetic nephropathy [0.03%]
糖尿病亚肾切除大鼠模型的高血糖和肾脏肿瘤消融技术协同增加尿白蛋白：对糖尿病肾病建模的意义
Li-Hao Chen,Bailey Stead,Suzanne L Advani et al.
Li-Hao Chen et al.
BACKGROUND/AIMSBACKGROUND/AIMS: While experimental models that emulate diabetic nephropathy are valuable tools for elucidating pathogenetic mechanisms and developing novel therapies, existing models imperfectly recapitulate human disease. I...
Renoprotective action of a matrix metalloproteinase inhibitor in progressive mesangioproliferative nephritis [0.03%]
基质金属蛋白酶抑制剂在进行性膜增生性肾小球肾炎中发挥肾保护作用
Takayuki Kuroda,Masao Masui,Mitsuru Notoya et al.
Takayuki Kuroda et al.
Background/aim: Matrix metalloproteinases (MMPs) play pivotal roles in extracellular matrix turnover and are involved in chronic kidney disease. The renoprotective action of a synthetic MMP inhibitor, compound A, was inve...
Osteopontin plays a critical role in interstitial fibrosis but not glomerular sclerosis in diabetic nephropathy [0.03%]
骨结蛋白在糖尿病肾病间质纤维化而不是肾小球硬化中起关键作用
Tomoaki Nagao,Takafumi Okura,Jun Irita et al.
Tomoaki Nagao et al.
Background/aims: Osteopontin (OPN) has been implicated in the pathology of several renal conditions. The aim of this study was to clarify the roles of OPN in diabetic nephropathy. ...
Association of HCV core antigen seropositivity with long-term mortality in patients on regular hemodialysis [0.03%]
慢性血液透析患者HCV核心抗原阳性与长期死亡风险的相关性研究
Akihiko Kato,Takako Takita,Mitsuyoshi Furuhashi et al.
Akihiko Kato et al.
Anti-hepatitis C virus (HCV) antibody seropositivity is independently associated with poor prognosis in hemodialysis (HD) patients. However, anti-HCV antibody cannot distinguish between patients with active infection and those who have reco...
Infectious risks and optimal strength of maintenance immunosuppressants in rituximab-treated kidney transplantation [0.03%]
利妥昔单抗治疗的肾脏移植患者感染风险与最佳维持免疫抑制强度
Chung Hee Baek,Won Seok Yang,Kyung Sun Park et al.
Chung Hee Baek et al.
Background: Rituximab, an anti-CD20 antibody, effectively depletes B lymphocytes. It is not clear whether the use of conventional doses of mycophenolate mofetil (MMF), methylprednisolone and tacrolimus as maintenance immu...
Hemodiafiltration improves plasma 25-hepcidin levels: a prospective, randomized, blinded, cross-over study comparing hemodialysis and hemodiafiltration [0.03%]
血透滤过可以提高血清25-肝素水平：一项前瞻、随机和盲法的血透析与血透滤过对比交叉试验研究
Bergur V Stefánsson,Mats Abramson,Ulf Nilsson et al.
Bergur V Stefánsson et al.
Background/aims: Data from studies comparing the effect of hemodiafiltration (HDF) and conventional hemodialysis (HD) on clinically important outcomes are insufficient to support superiority of HDF. None of these studies ...
Comparison of volume status in asymptomatic haemodialysis and peritoneal dialysis outpatients [0.03%]
无症状血液透析与腹膜透析患者的容量状态比较分析
Eugenia Papakrivopoulou,John Booth,Jennifer Pinney et al.
Eugenia Papakrivopoulou et al.
Background: The majority of haemodialysis (HD) patients gain weight between dialysis sessions and thereby become volume overloaded, whereas peritoneal dialysis (PD) is a more continuous technique. Cardiovascular mortality...
The role of apelin on the alleviative effect of Angiotensin receptor blocker in unilateral ureteral obstruction-induced renal fibrosis [0.03%]
阿普林在血管紧张素受体阻滞剂缓解单侧输尿管结扎诱导的肾纤维化中的作用研究
Masashi Nishida,Yasuko Okumura,Tatsujiro Oka et al.
Masashi Nishida et al.
Background: Apelin is a selective endogenous ligand of the APJ receptor, which genetically has closest identity to the angiotensin II type 1 receptor (AT-1). The effects of the apelin/APJ system on renal fibrosis still re...
Fas Ligand Has a Greater Impact than TNF-α on Apoptosis and Inflammation in Ischemic Acute Kidney Injury [0.03%]
fas配体比肿瘤坏死因子-α在缺血性急性肾损伤中的促凋亡和促炎作用更强
Kengo Furuichi,Satoshi Kokubo,Akinori Hara et al.
Kengo Furuichi et al.
Background/aim: Fas ligand (FasL) and tumor necrosis factor (TNF)-α are major pro-apoptotic molecules and also induce inflammation through cytokine and chemokine production. Although precise intracellular mechanisms of a...