Jinhwan Lim,Vincent H Gattone nd,Rachel Sinders et al.
Jinhwan Lim et al.
Background/aims: Phototherapy using a narrow-band, near-infrared (NIR) light (using a light-emitting diode, LED) is being used to treat certain medical conditions. This narrow-band red light has been shown to stimulate cy...
Adeno-Associated Virus-Mediated Gene Transfer to Renal Tubule Cells via a Retrograde Ureteral Approach [0.03%]
逆向输尿管递送腺相关病毒介导的肾小管上皮细胞基因转移疗法
Daniel C Chung,Ben Fogelgren,Kwon Moo Park et al.
Daniel C Chung et al.
Background/aims: Gene therapy involves delivery of exogenous DNA to provide a therapeutic protein. Ideally, a gene therapy vector should be non-toxic, non-immunogenic, easy to produce, and efficient in protecting and deli...
Implications of a reduction in the hemoglobin target in erythropoiesis-stimulating agent-treated hemodialysis patients [0.03%]
促红细胞生成素治疗的血液透析患者降低目标血红蛋白水平的影响
Timothy V Nguyen,David S Goldfarb
Timothy V Nguyen
Background: Patients treated with erythropoiesis-stimulating agents (ESAs) to a hemoglobin (Hb) level >12.0 g/dl have increased risk of multiple complications, including death. The optimal Hb target for ESA use has not be...
Mannitol Reduces the Hydrostatic Pressure in the Proximal Tubule of the Isolated Blood-Perfused Rabbit Kidney during Hypoxic Stress and Improves Its Function [0.03%]
甘露醇降低缺氧应激下整体灌注兔肾近端小管内的静水压并改善其功能
Robbert Bipat,Paul Steels,Yves Cuypers et al.
Robbert Bipat et al.
Background/aims: Hypoxia may play a role in the development of renal failure in donated kidneys. In the present study, the effects of hypoxia on isolated blood-perfused rabbit kidneys were investigated and the effects of ...
Exploring the Relationships between Hemoglobin, the Endothelium and Vascular Health in Patients with Chronic Kidney Disease [0.03%]
慢性肾脏病患者血红蛋白、血管内皮细胞和血管健康之间的关系研究
Catherine Weber,Mhairi Sigrist,Alexandra Romann et al.
Catherine Weber et al.
Background/aims: The ideal hemoglobin target in chronic kidney disease remains unknown. Ultimately, individualized targets may depend upon the properties of the patient's endothelial and vascular milieu, and thus the comp...
Crosstalk between Smad and Mitogen-Activated Protein Kinases for the Regulation of Apoptosis in Cyclosporine A- Induced Renal Tubular Injury [0.03%]
环孢素A致肾小管损伤诱导的凋亡过程中Smad与MAPK信号通路交互作用的研究进展
Hideyuki Iwayama,Tatsuo Sakamoto,Akihiro Nawa et al.
Hideyuki Iwayama et al.
Background/aims: It remains elusive whether there is a crosstalk between Smad and mitogen-activated protein kinases (MAPKs) and whether it regulates cyclosporine A (CyA)-induced apoptosis in renal proximal tubular cells (...
Serum high-sensitivity cardiac troponin T is a significant biomarker of left-ventricular diastolic dysfunction in subjects with non-diabetic chronic kidney disease [0.03%]
高敏肌钙蛋白T是糖尿病慢性肾病患者左室舒张功能不全的重要标志物
Masashi Kitagawa,Hitoshi Sugiyama,Hiroshi Morinaga et al.
Masashi Kitagawa et al.
Background: Chronic kidney disease (CKD) is associated with left-ventricular (LV) diastolic dysfunction (LVDD) which progresses to diastolic heart failure. However, biomarkers predicting LVDD in patients with CKD are larg...
Sabeen Habib,Qiuyu Zhang,Michel Baum
Sabeen Habib
Background/aims: Dietary protein deprivation during pregnancy causes hypertension in offspring when they become adults. This study examined if postnatal rearing had an effect on blood pressure and glomerular number in mal...
Compensatory thrombopoietin production from the liver and bone marrow stimulates thrombopoiesis of living rat megakaryocytes in chronic renal failure [0.03%]
慢性肾功能衰竭大鼠肝和骨髓产生的促补偿性血小板生成素刺激活体巨核细胞的增殖分化成熟及释放血小板
Itsuro Kazama,Yasuhiro Endo,Hiroaki Toyama et al.
Itsuro Kazama et al.
Background/aims: Decreased thrombopoiesis has been ascribed a role in the pathogenesis of uremic bleeding in chronic renal failure (CRF). However, serum thrombopoietin (TPO) levels are usually elevated in CRF patients, su...
Effects of tridocosahexaenoyl-glycerol emulsion on proteinuria in rats with nephrotoxic serum nephritis [0.03%]
鱼油甘油酯注射液对肾炎大鼠蛋白尿的影响
Norio Nakamura,Ryuichiro Kumasaka,Lu Yong Fu et al.
Norio Nakamura et al.
Background: Docosahexaenoic acid (DHA) is one of the n-3 polyunsaturated fatty acids and an important component of cell membrane phospholipids (PL). Nephrotoxic serum (NTS) nephritis was a worldwide model of the Goodpastu...