Effects of Chronic Antagonism of Endocannabinoid-1 Receptors on Glucose Tolerance and Insulin Action in Skeletal Muscles of Lean and Obese Zucker Rats [0.03%]
慢性阻断内源大麻素I型受体对肥胖及非肥胖zucker大鼠葡萄糖耐量和骨骼肌胰岛素作用的影响
Katherine A Lindborg,Stephan Jacob,Erik J Henriksen
Katherine A Lindborg
Background/aims: Antagonism of the endocannabinoid receptor-1 (CB1R) directly improves whole-body metabolic parameters of insulin resistance. The present investigation determined the effects of chronic CB1R antagonism on ...
Overnutrition and the Cardiorenal Syndrome: Use of a Rodent Model to Examine Mechanisms [0.03%]
过度营养与心肾综合征：应用 rodents 模型研究其机制
Adam Whaley-Connell,Lakshmi Pulakat,Vincent G DeMarco et al.
Adam Whaley-Connell et al.
Obesity has reached epidemic proportions with far-reaching health care and economic implications. Overnutrition, characterized by excess intake of carbohydrates and fats, has been associated with end-organ damage in several tissues, includi...
Eric J Chan,Kevin C Dellsperger
Eric J Chan
The term cardiorenal syndrome has evolved over the years. The understanding of the interactions between these two organ systems has led to better recognition and treatment strategies. As cardiovascular mortality is high in individuals with ...
James R Sowers,Adam Whaley-Connell,Melvin R Hayden
James R Sowers
The presence of a group of interactive maladaptive factors including hypertension, insulin resistance, metabolic dyslipidemia, obesity, microalbuminuria, and/or reduced renal function constitute the cardiorenal metabolic syndrome (CRS). Ove...
James R Sowers
James R Sowers
Estimated Glomerular Filtration Rate in Short-Risk Stratification in Acute Myocardial Infarction [0.03%]
急性心肌梗死短期风险评估中估计肾小球滤过率的作用
Luisa Blasco,Rafael Sanjuan,Nieves Carbonell et al.
Luisa Blasco et al.
Background/aims: Renal dysfunction is associated with a higher risk of cardiovascular disease in patients with acute myocardial infarction (AMI). The aim of this study was to investigate the independent prognostic value o...
The Association between Parathyroid Hormone Levels and the Cardiorenal Metabolic Syndrome in Non-Diabetic Chronic Kidney Disease [0.03%]
非糖尿病慢性肾脏病患者中甲状旁腺素水平与心血管代谢综合征的相关性研究
Georges Saab,Adam Whaley-Connell,Andrew Bombeck et al.
Georges Saab et al.
Aims: The relationship between parathyroid hormone (PTH) and the cardiorenal metabolic syndrome was examined among non-diabetic persons with chronic kidney disease (CKD). ...
An Emerging Role for Understanding Orthostatic Hyp'er'tension in the Cardiorenal Syndrome [0.03%]
直立性高血压在心肾综合征中作用的初步探讨
Jaya P Buddineni,Laxmi Chauhan,Syed T Ahsan et al.
Jaya P Buddineni et al.
Orthostatic hypertension (OHT) is a clinically important problem increasingly recognized in persons with borderline hypertension, diabetes mellitus, and autonomic neuropathies, and in the elderly. Moreover, the association of OHT with progr...
The Impact of Overnutrition on Insulin Metabolic Signaling in the Heart and the Kidney [0.03%]
过度营养对心脏和肾脏胰岛素代谢信号的影响
Lakshmi Pulakat,Vincent G DeMarco,Adam Whaley-Connell et al.
Lakshmi Pulakat et al.
Overnutrition characterized by overconsumption of food rich in fat and carbohydrates is a significant contributor to hypertension, type 2 diabetes, and the cardiorenal syndrome. Overnutrition activates the renin-angiotensin-aldosterone syst...