David Klachko,Adam Whaley-Connell
David Klachko
Metformin is an insulin-sensitizing agent with anti-hyperglycemic properties that is widely used for the treatment of type-2 diabetes. The efficacy of metformin in reducing hyperglycemia is well established, and there is emerging evidence t...
Childhood-Adolescent Obesity in the Cardiorenal Syndrome: Lessons from Animal Models [0.03%]
取自动物模型的心肾综合征中的儿童和青少年肥胖问题：后见之明
Melvin R Hayden,James R Sowers
Melvin R Hayden
Background/aims: Childhood-adolescent overweight and obesity have grown to pandemic proportions during the past decade. The onset of obesity in younger adults will likely be manifested as earlier onset of myocardial and r...
Role of Growth Hormone Deficiency and Treatment in Chronic Kidney Disease [0.03%]
生长激素缺乏及其治疗在慢性肾脏疾病中的作用
Diptesh Gupta,Michael Gardner,Adam Whaley-Connell
Diptesh Gupta
Malnutrition and inflammation are strong predictors of mortality in advanced kidney disease, especially in patients on renal replacement therapy. The complex relationship between kidney disease, uremia, and malnutrition significantly contri...
Craig S Stump
Craig S Stump
Chronic kidney disease (CKD) is an important risk factor for cardiovascular disease (CVD) and mortality. The increase in CKD in recent decades has paralleled increases in obesity, diabetes, and the metabolic syndrome. Physical inactivity is...
Elevated Levels of N-Terminal Pro-Brain Natriuretic Peptide in Patients with Chronic Dyspnea and Moderate Renal Dysfunction: Decreased Clearance or Increased Cardiac Stress [0.03%]
慢性呼吸困难和中度肾功能不全患者N端脑利钠肽前体水平升高：清除率降低或心脏应激增加？
Siegfried Wieshammer,Jens Dreyhaupt,Beate Basler
Siegfried Wieshammer
Background/aims: Serum levels of N-terminal pro-brain natriuretic peptide (NT-proBNP) are often increased in patients with impaired renal function. The objective of this study was to investigate whether the increase in NT...
Plasma Brain Natriuretic Peptide Levels in Cardiac Function Assessment in Chronic Dialysis Patients [0.03%]
透析患者心脏功能评估中的血浆脑利钠肽水平测定
R Sanjuan,S Martín Oliva,M L Blasco et al.
R Sanjuan et al.
Background: Brain natriuretic peptide (BNP) is elevated in patients with end-stage renal disease and could reflect left ventricular dysfunction. Aim: ...
Hypertensive Cardiovascular and Renal Disease and Target Organ Damage: Lessons from Animal Models [0.03%]
动物模型教给我们的高血压、心血管及肾脏疾病和靶器官损害
Dinko Susic,Edward D Frohlich
Dinko Susic
This brief review discusses some aspects of hypertensive damage to the kidneys and cardiovascular system. A comparison of renal and cardiac manifestations of hypertensive disease between results of clinical and experimental studies was made...
Hypoglycemia: A Possible Link between Insulin Resistance, Metabolic Dyslipidemia, and Heart and Kidney Disease (the Cardiorenal Syndrome) [0.03%]
低血糖：胰岛素抵抗、代谢性脂质异常、心脏和肾脏疾病（心肾综合征）之间的可能联系
Myriam Ensling,William Steinmann,Adam Whaley-Connell
Myriam Ensling
Resistance to insulin metabolic signaling in adipose tissue contributes to the lipid abnormalities in obese, hyperinsulinemic, insulin-resistant patients who develop the cardiorenal syndrome. These same metabolic dyslipidemic abnormalities ...
Central Pressure and Biomarker Responses to Renin Inhibition with Hydrochlorothiazide and Ramipril in Obese Hypertensives: The ATTAIN Study [0.03%]
高血压肥胖患者使用氢氯噻嗪和雷米普利抑制肾素的中心血压及生物标志物反应：ATTAIN研究
Adam Whaley-Connell,Das Purkayastha,Anthony Yadao et al.
Adam Whaley-Connell et al.
Background/aims: In obese, hypertensive subjects, the renin-angiotensin system (RAS) is enhanced and natriuresis impaired, suggesting a role for combination RAS blockade with diuretics. Data suggest that renin inhibition ...
Diabetic Cardiovascular Disease Predicts Chronic Kidney Disease Awareness in the Kidney Early Evaluation Program [0.03%]
糖尿病心血管疾病与肾脏早期评估计划中的慢性肾病知晓之间的关系
Adam Whaley-Connell,Andrew S Bomback,Samy I McFarlane et al.
Adam Whaley-Connell et al.
Aims: Lack of chronic kidney disease (CKD) awareness is common. Recent data suggest that the presence of concurrent diabetes may heighten CKD awareness, but current data have not supported the hypothesis that healthcare d...