Systemic Succinate, Hypoxia-Inducible Factor-1 Alpha, and IL-1β Gene Expression in Autosomal Dominant Polycystic Kidney Disease with and without Hypertension [0.03%]
常染色体显性多囊肾病合并和不合并高血压患者的系统性丁酸钠、缺氧诱导因子-1 alpha和IL-1β基因表达状况
Ismail Kocyigit,Serpil Taheri,Eray Eroglu et al.
Ismail Kocyigit et al.
Background and objectives: Cyst pressure induces renin-angiotensin-aldosterone system activation and kidney hypoxia in autosomal dominant polycystic kidney disease (ADPKD). Lipopolysaccharide-induced Toll-like receptor ac...
Neurohormonal, Endocrine, and Immune Dysregulation and Inflammation in Cardiorenal Syndrome [0.03%]
心肾综合征中的神经激素、内分泌和免疫失调及炎症
Anna Clementi,Grazia Maria Virzì,Giovanni Giorgio Battaglia et al.
Anna Clementi et al.
"Organ crosstalk" is the complex physiological communication between different body systems, and it is necessary for the optimal equilibrium and functioning of the organism. In particular, heart and kidney function is tightly connected, and...
Loss of the Normal Gradient in Arterial Compliance and Outcomes of Chronic Kidney Disease Patients [0.03%]
动脉顺应性正常梯度丧失与慢性肾脏病患者的预后关系研究
Qiong Bai,Chun-Yan Su,Ai-Hua Zhang et al.
Qiong Bai et al.
Background: In dialysis patients, loss of the normal gradient in arterial compliance, assessed by the pulse wave velocity (PWV) ratio, predicts all-cause mortality better than does carotid-femoral PWV (CF-PWV) alone. Howe...
Plasma Lipopolysaccharide Concentrations in Cardiorenal Syndrome Type 1 [0.03%]
1型心肾综合征患者血浆脂多糖浓度的变化及其与临床结局的关系
Grazia Maria Virzì,Andrea Breglia,Ghada Ankawi et al.
Grazia Maria Virzì et al.
Background: Cardiorenal syndrome (CRS) type 1 is characterized by a rapid worsening of cardiac function that leads to acute kidney injury (AKI). This study evaluated the role of lipopolysaccharide (LPS) in the development...
Echocardiographic Findings in Patients with Mild to Moderate Chronic Kidney Disease without Symptomatic Heart Failure: A Population-Based Study [0.03%]
轻中度慢性肾脏病无症状心力衰竭患者的超声心动图特征——一项基于人口的研究
Liana Xhakollari,Margret Leosdottir,Martin Magnusson et al.
Liana Xhakollari et al.
Background: Renal dysfunction is an established risk factor for cardiovascular disease, but early disease states in both organs are poorly studied. Object...
Initial Concentrations of miR-1 MicroRNA Precursor and High-Sensitivity Troponin in the Diagnosis of Non-ST Myocardial Infarction among Patients with and Those without Chronic Kidney Disease [0.03%]
慢性肾脏病患者和非慢性肾脏病患者中miR-1前体初始浓度及高敏心肌肌钙蛋白在非ST段抬高型心梗诊断中的应用价值研究
Tong Su,Xiaonan Shao,Xiaopu Zhang et al.
Tong Su et al.
Background: The early diagnosis of non-ST-segment elevation myocardial infarction (NSTEMI) in patients with chronic kidney disease (CKD) remains a challenge. ...
Mariana Murea,Lijun Ma,Barry I Freedman
Mariana Murea
Effects of Bardoxolone Methyl on Magnesium in Patients with Type 2 Diabetes Mellitus and Chronic Kidney Disease [0.03%]
巴德索隆甲基对2型糖尿病合并慢性肾脏病患者镁水平的影响
Dana V Rizk,Arnold L Silva,Pablo E Pergola et al.
Dana V Rizk et al.
Background: Treatment with bardoxolone methyl (Bard) in a multinational phase 3 trial, Bardoxolone Methyl Evaluation in Patients with Chronic Kidney Disease and Type 2 Diabetes (BEACON), resulted in increases in estimated...
Clinical Trial
Cardiorenal medicine. 2019;9(5):316-325. DOI:10.1159/000500612 2019
Melanie P Chin,Shannon Rich,Angie Goldsberry et al.
Melanie P Chin et al.
Background: Bardoxolone methyl has been shown to increase eGFR in several clinical trials, including a phase 3 trial in patients with type 2 diabetes and stage 4 CKD (BEACON), which was terminated early due to an increase...
Randomized Controlled Trial
Cardiorenal medicine. 2019;9(5):326-333. DOI:10.1159/000500736 2019
Cardiometabolic-Renal Disease in South Asians: Consensus Recommendations from the Cardio Renal Society of America [0.03%]
南亚人群的卡替代谢-肾脏疾病：美国心血管肾脏学会共识建议
Krishnaswami Vijayaraghavan,Peter A McCullough,Bhupinder Singh et al.
Krishnaswami Vijayaraghavan et al.
Background: Rates of cardiometabolic-renal disease are extremely high among South Asians (India, Pakistan, Bangladesh, Sri Lanka, Bhutan, the Maldives, and Nepal) residing in their home countries and worldwide. The Cardio...