Non-viral Gene Delivery [0.03%]
非病毒基因传递
Chi Hong Sum,Samantha Marisha Shortall,Shirley Wong et al.
Chi Hong Sum et al.
Although viral vectors comprise the majority of gene delivery vectors, their various safety, production, and other practical concerns have left a research gap to be addressed. The non-viral vector space encompasses a growing variety of phys...
Introduction [0.03%]
简介
Roderick Adrian Slavcev
Roderick Adrian Slavcev
Gene therapy is the delivery of nucleic acid for the expression of a therapeutic product in order to treat diseases on a genetic level. This is especially well suited for diseases that involve missing, defective, or overexpressing genes.
Avril A B Robertson
Avril A B Robertson
Modulation of inflammasomes has tremendous therapeutic potential and is hotly pursued by industry and academia alike. Indeed a growing number of patents are emerging to protect the intellectual property in valuable compound classes. This ch...
Genetics of Inflammasomes [0.03%]
炎性体的遗传学研究
Wanessa Cardoso da Silva,Edione C Reis,Telma M Oshiro et al.
Wanessa Cardoso da Silva et al.
Mutations in inflammasome genes are responsible for rare monogenic and polygenic autoinflammatory diseases. On the other side, genetic polymorphisms in the same molecules contribute to the development of common multifactorial diseases (i.e....
Aging and the Inflammasomes [0.03%]
衰老与炎性体
Fabiola Marín-Aguilar,Jesús Ruiz-Cabello,Mario D Cordero
Fabiola Marín-Aguilar
The inflammasomes are innate immune system sensors that control the activation of caspase-1 and induce inflammation in response to infectious microbes and molecules originating from host proteins, leading to the release of pro-inflammatory ...
Inflammasome and Cancer [0.03%]
炎性小体与癌症
Zhiyu Wang,Neng Wang,Yifeng Zheng et al.
Zhiyu Wang et al.
The current chapter focuses on the role of inflammasome in cancer prevention and development. Emerging evidence suggested that inflammasome is closely correlated with elevated levels of IL-1β and IL-18, activation of NF-κB signaling, enha...
Gabriel Mbalaviele,Deborah J Veis
Gabriel Mbalaviele
Unresolved inflammation is harmful to any tissues in the organism. Bone in particular is vulnerable to inflammatory assaults because its integrity depends on the activity of osteoclasts, which arise from myeloid precursors. Osteoclasts are ...
Mazhar A Kanak,Yoshitaro Shindo,Pavithra SaiKumar et al.
Mazhar A Kanak et al.
Many diseases of the gastrointestinal tract have been attributed to chronic inflammation, and a few have identified the role of inflammasomes in their pathogenesis. Inflammasomes are a group of protein complexes comprising of several intrac...
Viktória Jeney
Viktória Jeney
Damage-associated molecular patterns (DAMPs) or alarmins are endogenous danger signals that are derived from damaged cells and extracellular matrix degradation, capable of triggering innate immune response to promote tissue damage repair. H...
Inflammasomes in the Kidney [0.03%]
肾脏中的炎性小体
Holly L Hutton,Maliha A Alikhan,A Richard Kitching
Holly L Hutton
Inflammasomes influence a diverse range of kidney disease, including acute and chronic kidney diseases, and those mediated by innate and adaptive immunity. Both IL-18 and in particular IL-1β are validated therapeutic targets in several kid...