N-Glycan Biosynthesis: Basic Principles and Factors Affecting Its Outcome [0.03%]
N-糖链生物合成：基本原理及影响其结果的因素
Teemu Viinikangas,Elham Khosrowabadi,Sakari Kellokumpu
Teemu Viinikangas
Carbohydrate chains are the most abundant and diverse of nature's biopolymers and represent one of the four fundamental macromolecular building blocks of life together with proteins, nucleic acids, and lipids. Indicative of their essential ...
Frédérique Lisacek,Kathirvel Alagesan,Catherine Hayes et al.
Frédérique Lisacek et al.
Analytical methods developed for studying immunoglobulin glycosylation rely heavily on software tailored for this purpose. Many of these tools are now used in high-throughput settings, especially for the glycomic characterization of IgG. A ...
Jenifer L Hendel,Richard A Gardner,Daniel I R Spencer
Jenifer L Hendel
The development of reliable, affordable, high-resolution glycomics technologies that can be used for many samples in a high-throughput manner are essential for both the optimization of glycosylation in the biopharmaceutical industry as well...
Capillary (Gel) Electrophoresis-Based Methods for Immunoglobulin (G) Glycosylation Analysis [0.03%]
基于毛细管（凝胶）电泳的免疫球蛋白(G)糖基化分析方法
Samanta Cajic,René Hennig,Robert Burock et al.
Samanta Cajic et al.
The in-depth characterization of protein glycosylation has become indispensable in many research fields and in the biopharmaceutical industry. Especially knowledge about modulations in immunoglobulin G (IgG) N-glycosylation and their effect...
Mass Spectrometry-Based Methods for Immunoglobulin G N-Glycosylation Analysis [0.03%]
基于质谱的免疫球蛋白G N-连接糖基化分析方法
Siniša Habazin,Jerko Štambuk,Jelena Šimunović et al.
Siniša Habazin et al.
Mass spectrometry and its hyphenated techniques enabled by the improvements in liquid chromatography, capillary electrophoresis, novel ionization, and fragmentation modes are truly a cornerstone of robust and reliable protein glycosylation ...
Lectin and Liquid Chromatography-Based Methods for Immunoglobulin (G) Glycosylation Analysis [0.03%]
基于凝集素和液相色谱的免疫球蛋白(G)糖基化分析方法
Tea Petrović,Irena Trbojević-Akmačić
Tea Petrović
Immunoglobulin (Ig) glycosylation has been shown to dramatically affect its structure and effector functions. Ig glycosylation changes have been associated with different diseases and show a promising biomarker potential for diagnosis and p...
Yusuke Mimura,Radka Saldova,Yuka Mimura-Kimura et al.
Yusuke Mimura et al.
Therapeutic monoclonal antibodies (mAbs) are mostly of the IgG class and constitute highly efficacious biopharmaceuticals for a wide range of clinical indications. Full-length IgG mAbs are large proteins that are subject to multiple posttra...
Chromosomal Aberrations with Endocrine Relevance (Turner Syndrome, Klinefelter Syndrome, Prader-Willi Syndrome) [0.03%]
具有内分泌相关性的染色体异常（特纳综合征、克林费尔特综合征、普拉德-威利综合征）
Irén Haltrich
Irén Haltrich
Turner and Klinefelter syndromes are the most common chromosome abnormalities compatible with life. Prader-Willi syndrome is a complex multisystem imprinting disorder characterized by hypothalamic dysfunction, neurological implications, and...
Genetics of Obesity [0.03%]
肥胖的遗传学
Lotte Kleinendorst,Mieke M van Haelst,Erica L T van den Akker
Lotte Kleinendorst
Obesity is caused by an imbalance between energy intake and output, influenced by numerous environmental, biological, and genetic factors. Only a minority of people with obesity have a genetic defect that is the main cause of their obesity....
Zsolt Gaál,István Balogh
Zsolt Gaál
In addition to the common types of diabetes mellitus, two major monogenic diabetes forms exist. Maturity-onset diabetes of the young (MODY) represents a heterogenous group of monogenic, autosomal dominant diseases. MODY accounts for 1-2% of...