Raphaëlle Toledano Zur,Galit Adler,Katerina Shamalov et al.
Raphaëlle Toledano Zur et al.
As an important part of the immune system, T lymphocytes exhibit undoubtedly an important role in targeting and eradicating cancer. However, despite these characteristics, their natural antitumor response may be insufficient. Numerous clini...
Jacek R Wilczyński
Jacek R Wilczyński
Cancer stem cells are a population of cells enable to reproduce the original phenotype of the tumor and capable to self-renewal, which is crucial for tumor proliferation, differentiation, recurrence, and metastasis, as well as chemoresistan...
The Role of Myeloid-Derived Suppressor Cells in Tumor Growth and Metastasis [0.03%]
髓源抑制细胞在肿瘤生长和转移中的作用
Defne Bayik,Juyeun Lee,Justin D Lathia
Defne Bayik
Myeloid-derived suppressor cells (MDSCs) are immature bone marrow-derived suppressive cells that are an important component of the pathological immune response associated with cancer. Expansion of MDSCs has been linked to poor disease outco...
Iñigo Terrén,Francisco Borrego
Iñigo Terrén
Natural Killer (NK) cells are effector lymphocytes with the ability to generate an antitumor response. NK cells encompass a diverse group of subsets with different properties and have the capacity to kill cancer cells by different means. Ho...
Izabela Szulc-Kielbik,Magdalena Klink
Izabela Szulc-Kielbik
Tumor microenvironment (TME) is a dynamic network that apart from tumor cells includes also cells of the immune system, e.g., neutrophils, which are recruited from blood circulation. In TME, neutrophils are strongly implicated in the direct...
Tumor-Associated Macrophages: Reasons to Be Cheerful, Reasons to Be Fearful [0.03%]
肿瘤相关巨噬细胞：值得高兴的理由和担心的理由
Izabela Szulc-Kielbik,Michal Kielbik
Izabela Szulc-Kielbik
Tumor microenvironment (TME) is a complex and constantly evolving entity that consists not only of cancer cells, but also of resident host cells and immune-infiltrating cells, among which macrophages are significant components, due to their...
Tumor-Infiltrating Lymphocytes and Their Role in Solid Tumor Progression [0.03%]
肿瘤浸润性淋巴细胞及其在实体瘤进展中的作用
Theresa L Whiteside
Theresa L Whiteside
Tumor-infiltrating lymphocytes (TIL) are an important component of the tumor environment. Their role in tumor growth and progression has been debated for decades. Today, emphasis has shifted to beneficial effects of TIL for the host and to ...
Michael P Rogers,Zhiyong Mi,Neill Y Li et al.
Michael P Rogers et al.
The understanding of how normal cells transform into tumor cells and progress to invasive cancer and metastases continues to evolve. The tumor mass is comprised of a heterogeneous population of cells that include recruited host immune cells...
Cancer Immunoediting: Elimination, Equilibrium, and Immune Escape in Solid Tumors [0.03%]
肿瘤免疫编辑：实体瘤中的消除、平衡与免疫逃逸现象
Jacek R Wilczyński,Marek Nowak
Jacek R Wilczyński
Emphasizing the dynamic processes between cancer and host immune system, the initially discovered concept of cancer immunosurveillance has been replaced by the current concept of cancer immunoediting consisting of three phases: elimination,...
Glycosylation of Antigen-Specific Antibodies: Perspectives on Immunoglobulin G Glycosylation in Vaccination and Immunotherapy [0.03%]
针对抗原的抗体的糖基化：对免疫球蛋白G的糖基化在疫苗和免疫治疗中的看法
Pranay Bharadwaj,Margaret E Ackerman
Pranay Bharadwaj
Exciting developments have been made in understanding antibody-mediated immunity, deepening understanding of antibody effector functions increasingly recognized as critical mechanisms of action beyond antigen recognition, and significantly ...