Galanin and addiction [0.03%]
兰尼碱与药物成瘾性
Marina R Picciotto
Marina R Picciotto
There has been increasing interest in the ability of neuropeptides involved in feeding to modulate circuits important for responses to drugs of abuse. A number of peptides with effects on hypothalamic function also modulate the mesolimbic d...
J T Lerner,R Sankar,A M Mazarati
J T Lerner
Neuroanatomical localization and physiological properties of galanin suggest that the peptide may be involved in the regulation of seizures. Indeed, administration of galanin receptor agonists into brain areas pertinent to the initiation an...
Eugenia Kuteeva,Tomas Hökfelt,Tara Wardi et al.
Eugenia Kuteeva et al.
The pathophysiology of depression remains unclear, but involves disturbances in brain monoaminergic transmission. Current antidepressant drugs, which act by enhancing this type of neurotransmission, have limited therapeutic efficacy in a nu...
Scott E Counts,Sylvia E Perez,Stephen D Ginsberg et al.
Scott E Counts et al.
Galanin (GAL) and GAL receptors (GALR) are overexpressed in degenerating brain regions associated with cognitive decline in Alzheimer's disease (AD). The functional consequences of GAL plasticity in AD are unclear. GAL inhibits cholinergic ...
Galanin impairs cognitive abilities in rodents: relevance to Alzheimer's disease [0.03%]
神肽损害啮齿类动物的认知能力：与阿尔茨海默病的关系
J N Crawley
J N Crawley
The neuropeptide galanin and its receptors are localized in brain pathways that mediate learning and memory. Central microinjection of galanin impairs performance of a variety of cognitive tasks in rats. Transgenic mice overexpressing galan...
Neurochemical modulation of central cardiovascular control: the integrative role of galanin [0.03%]
脑干心血管控制的神经化学调节：生长抑素的整合作用
Zaida Díaz-Cabiale,Concepción Parrado,Manuel Narváez et al.
Zaida Díaz-Cabiale et al.
Galanin (GAL) is a peptide involved in multiple functions, including central cardiovascular control. In this review, the role of GAL and its fragments in the modulation of cardiovascular neuronal networks in the nucleus of the solitary trac...
Galanin and consummatory behavior: special relationship with dietary fat, alcohol and circulating lipids [0.03%]
胃泌素和摄取行为：与膳食脂肪、酒精和循环脂质的特殊关系
Jessica R Barson,Irene Morganstern,Sarah F Leibowitz
Jessica R Barson
Galanin (GAL) plays an integral role in consummatory behavior. In particular, hypothalamic GAL has a positive, reciprocal relationship with dietary fat and alcohol. In this relationship, GAL increases the consumption of fat or alcohol which...
Istvan Merchenthaler
Istvan Merchenthaler
Galanin has diverse physiological functions, including nociception, arousal/sleep regulation, cognition, and many aspects of neuroendocrine activities that are associated with feeding, energy metabolism, thermoregulation, osmotic and water ...
Galanin in glia: expression and potential roles in the CNS [0.03%]
星形胶质细胞中的galanin：表达及其在中枢神经系统中可能的作用
Helmut Butzkueven,Andrew L Gundlach
Helmut Butzkueven
The roles of galanin in central nervous system (CNS) development and the normal adult CNS have been extensively reviewed in this volume and elsewhere. There is also ample evidence that galanin expression is induced following neural injury i...
J W Bauer,R Lang,M Jakab et al.
J W Bauer et al.
The skin, the largest organ of the body, functions as a barrier between the body proper and the external environment, as it is constantly exposed to noxious stressors. During the last few years, the concept of an interactive network involvi...