Rajeshwar P Verma
Rajeshwar P Verma
Matrix metalloproteinases (MMPs), an increasing family of zinc- and calcium-dependent endopeptidases, are involved in both the tissue remodeling and the degradation of extracellular matrix (ECM). These enzymes have been a pharmaceutical tar...
Mange Ram Yadav,Prashant Revan Murumkar,Vishal Prakash Zambre
Mange Ram Yadav
Matrix metalloproteinases (MMPs) play an important role in many physiological and pathological processes. Development of MMP inhibitors, in particular collagenase inhibitors, for the treatment of arthritis has been more challenging, undoubt...
Snehasikta Swarnakar,Amartya Mishra,Susri Ray Chaudhuri
Snehasikta Swarnakar
The interest in gelatinases is increased because of their association in diverse human diseases, though the relationship between MMP expression and disease progression is very complex and varies in cell to cell. Targeting gelatinases in dis...
Satya P Gupta,Vaishali M Patil
Satya P Gupta
Matrix metalloproteinases (MMPs) regulate a wide range of biological functions; hence, they have invited great attention for the studies on their structures and functions, and since their overactivation leads to several diseases, the design...
Matrix metalloproteinases [0.03%]
基质金属蛋白酶
Viola Vargová,Marek Pytliak,Viola Mechírová
Viola Vargová
Remodeling of extracellular matrix is crucial for many physiological (cell migration, proliferation, growth, and development) and pathological (remodeling of heart, carcinogenesis, metastasis, etc.) events. Thus, the interaction between cel...
Matrix metalloproteinase inhibitors: specificity of binding and structure-activity relationships [0.03%]
金属基质素蛋白酶抑制剂的专一性及构效关系研究
Satya P Gupta
Satya P Gupta
Galanin-like peptide: neural regulator of energy homeostasis and reproduction [0.03%]
类似加兰肽的神经肽：能量和繁殖调节者
Catherine B Lawrence,Gregory S Fraley
Catherine B Lawrence
Galanin-like peptide (GALP) was discovered in 1999 in the porcine hypothalamus and was found to be a 60 amino-acid neuropeptide. GALP shares sequence homology to galanin (1-13) in position 9-21 and can bind to and activate the three galanin...
Galanin systems in non-mammalian vertebrates with special focus on fishes [0.03%]
鱼类中的极后素系统研究（以鱼类为重点）
Elsie Tachie Mensah,Helene Volkoff,Suraj Unniappan
Elsie Tachie Mensah
Galanin is a well characterized multifunctional neuropeptide in mammals. Galanin has been identified from several fishes, amphibians, reptiles and birds. A large set of data is available on galanin-like protein distribution and peptide and/...
I Rauch,Barbara Kofler
I Rauch
Many tumours of neuroendocrine origin, and also an increasing number of non-neuroendocrine cancers, have been shown to express neuropeptides and/or their corresponding receptors. These peptides and receptors represent the molecular basis fo...
Galanin systems and ischemia: peptide and receptor plasticity in neurons and oligodendroglial precursors [0.03%]
加兰肽系统与缺血：神经元和少突胶质前体细胞中的肽和受体可塑性
Pei-Juan Shen,Andrew L Gundlach
Pei-Juan Shen
Cerebral cortex contains few if any galanin neurons, but receives galanin-ergic inputs from subcortical areas. Apart from our earlier study on the response to cortical spreading depression, little is known about the presence and function of...