On the role of co-inhibitory molecules in dendritic cell: T helper cell coculture assays aimed to detect chemical-induced contact allergy [0.03%]
协同抑制分子在树突状细胞与辅助性T细胞共培养试验中鉴定接触过敏性化学物的作用研究
Matthias Peiser,Manuel Hitzler,Andreas Luch
Matthias Peiser
T cells play a pivotal role in sensitization and elicitation of type IV allergic reactions. While T helper cells sustain and maintain the differentiation of further effector cells, regulatory T cells are involved in control of cytokine rele...
Correlation of contact sensitizer potency with T cell frequency and TCR repertoire diversity [0.03%]
接触致敏剂效力与T细胞频率和TCR库多样性的相关性研究
Philipp R Esser,Ian Kimber,Stefan F Martin
Philipp R Esser
Allergic contact dermatitis is a T cell-mediated skin disease. Many hundreds of organic chemicals and some metal ions are contact sensitizers. They induce an innate inflammatory immune response in the skin that results in the priming of con...
Human T cell priming assay: depletion of peripheral blood lymphocytes in CD25(+) cells improves the in vitro detection of weak allergen-specific T cells [0.03%]
人T细胞活化试验：去除CD25阳性细胞可改善弱过敏原特异性T细胞的体外检测
Marc Vocanson,Amine Achachi,Virginie Mutez et al.
Marc Vocanson et al.
To develop an in vitro assay that recapitulates the key event of allergic contact dermatitis (ACD), that is the priming of effector T cells by hapten-presenting dendritic cells, and then allows for the sensitive detection of chemical allerg...
Tools and methods for identification and analysis of rare antigen-specific T lymphocytes [0.03%]
罕见抗原特异性T淋巴细胞的识别与分析方法及工具
Stefan F Martin,Sonja S Schmucker,Anne Richter
Stefan F Martin
T lymphocytes are essential as effector and memory cells for immune defense against infections and as regulatory T cells in the establishment and maintenance of immune tolerance. However, they are also involved in immune pathology being eff...
Contact hypersensitivity: quantitative aspects, susceptibility and risk factors [0.03%]
接触性超敏反应：定量特征、易感性和危险因素
Peter S Friedmann,Christopher Pickard
Peter S Friedmann
The development of allergic sensitisation by environmental chemicals results in allergic contact dermatitis and highly undesirable morbidity and disability. This form of hypersensitivity is mediated by specific T lymphocytes that recognise ...
Hans Ulrich Weltzien,Stefan F Martin,Jean-François Nicolas
Hans Ulrich Weltzien
T lymphocytes are instrumental in the prevention of infections. With their antigen-specific T cell receptor (TCR), these cells recognize short peptides in the peptide-binding groove on MHC molecules of antigen-presenting cells. However, con...
Christine Louis-Dit-Sully,Wolfgang W A Schamel
Christine Louis-Dit-Sully
Small chemical compounds and certain metal ions can activate T cells, resulting in drug hypersensitivity reactions that are a main problem in pharmacology. Mostly, the drugs generate new antigenic epitopes on peptide-major histocompatibilit...
Christine Louis-Dit-Sully,Britta Blumenthal,Marlena Duchniewicz et al.
Christine Louis-Dit-Sully et al.
Drug hypersensitivity reactions are immune mediated, with T lymphocytes being stimulated by the drugs via their T-cell antigen receptor (TCR). In the nonpathogenic state, the TCR is activated by foreign peptides presented by major histocomp...
E J Calabrese
E J Calabrese
This chapter explores the historical foundations of hormesis, including the underlying reasons for its marginalization during most of the twentieth century and factors that are contributing to its resurgence and acceptance within the toxico...