Circulating microRNA as Biomarkers in Hematological Malignancies [0.03%]
循环microRNA在血液系统恶性肿瘤中的生物标志物作用
Monika Stankova,Veronika Kubaczkova,Lenka Sedlarikova et al.
Monika Stankova et al.
Hematopoiesis is a highly regulated process controlled by a complex network of molecular mechanisms that simultaneously regulate differentiation, proliferation, and apoptosis of hematopoietic stem cells. Aberrant microRNA (miRNA) expression...
Petra Vychytilova-Faltejskova,Ondrej Slaby
Petra Vychytilova-Faltejskova
One of the major challenges in cancer research is the identification of stable biomarkers that could be routinely measured in easily accessible samples. Human blood and other body fluids represent rich sources for the identification of nove...
Henriett Butz,Attila Patócs
Henriett Butz
Specific and sensitive noninvasive biofluid-based biomarkers are always needed in the laboratory diagnosis of diseases. Biomarkers are applied not only for diagnostic purposes but for stratifying a disease and for assessing the therapy resp...
Anna M L Coenen-Stass,Imre Mäger,Mathew J A Wood
Anna M L Coenen-Stass
Great excitement has surrounded the finding that small RNAs are stable in various biofluids and carry specific signatures reflecting physiological and pathological states. In this chapter, we briefly describe the impact of this revolutionar...
Introduction to microRNAs: Biogenesis, Action, Relevance of Tissue microRNAs in Disease Pathogenesis, Diagnosis and Therapy-The Concept of Circulating microRNAs [0.03%]
微小核糖核酸入门：生物生成、作用、疾病发生机制、诊断与治疗中的组织微小核糖核酸的相关性以及循环微小核糖核酸的概念
Zoltán Nagy,Peter Igaz
Zoltán Nagy
MicroRNAs as the endogenous mediators of RNA interference have principal roles in gene expression regulation. Since their discovery in the early 1990s, their number has steadily grown to approximately 2500 known microRNAs at present in huma...
Daniel P Mulvihill
Daniel P Mulvihill
This year marks the 30th anniversary of the first description of the cellular distribution of actin within a yeast cell. Since then advances in both molecular genetics and imaging technologies have ensured research within these simple model...
Measuring two at the same time: combining magnetic tweezers with single-molecule FRET [0.03%]
同时测量两个参数：磁性钳和单分子FRET的结合使用
Marko Swoboda,Maj Svea Grieb,Steffen Hahn et al.
Marko Swoboda et al.
Molecular machines are the workhorses of the cell that efficiently convert chemical energy into mechanical motion through conformational changes. They can be considered powerful machines, exerting forces and torque on the molecular level of...
Leslie Conway,Jennifer L Ross
Leslie Conway
In this chapter, we describe experimental techniques used in vitro to illuminate how small teams of motors can work to translocate cargos. We will focus on experiments utilizing in vitro reconstitution, artificial or ex vivo purified cargos...
Mark DeWitt,Thomas Schenkel,Ahmet Yildiz
Mark DeWitt
Motor proteins convert the chemical energy of adenosine triphosphate (ATP) hydrolysis into directed movement along filamentous tracks, such as DNA, microtubule, and actin. The motile properties of motors are essential to their wide variety ...
Christopher Toepfer,James R Sellers
Christopher Toepfer
Myosins are a large superfamily of actin-dependent molecule motors that carry out many functions in cells. Some myosins are cargo carriers that move processively along actin which means that a single molecule of myosin can take many ATP-dep...