Ravi G Kurumbail,Matthew F Calabrese
Ravi G Kurumbail
AMP-activated protein kinase is a family of heterotrimeric serine/threonine protein kinases that come in twelve different flavors. They serve an essential function in all eukaryotes of conserving cellular energy levels. AMPK complexes are r...
Hypothetic Interindividual and Interspecies Relevance of microRNAs Released in Body Fluids [0.03%]
体液中释放的微小RNA的假设互个体和互物种相关性
Ivan Igaz,Peter Igaz
Ivan Igaz
MicroRNAs may not only be relevant within the organism, but microRNAs released in body fluids might affect other individuals and hypothetically also other species. Such interindividual and cross-species activity of microRNAs appears to be v...
Ivan Igaz,Peter Igaz
Ivan Igaz
By studying literature data and having performed an in silico analysis, the circulating microRNA expression profiles of healthy individuals appear to show an abundance of microRNAs with predominant tumor suppressor activity. We hypothesize ...
Circulating microRNAs as Hormones: Intercellular and Inter-organ Conveyors of Epigenetic Information? [0.03%]
循环microRNA作为激素：细胞间和器官间表观遗传信息的传递者？
Yusuke Yoshioka,Takeshi Katsuda,Takahiro Ochiya
Yusuke Yoshioka
The discovery of microRNAs (miRNAs) has created a paradigm shift not only in the traditional central dogma of molecular biology but also in the research of a variety of human diseases. Fourteen years after the discovery of miRNAs, there was...
Diagnostic Relevance of microRNAs in Other Body Fluids Including Urine, Feces, and Saliva [0.03%]
尿液、粪便和唾液等其他体液中microRNA的诊断价值
Ivan Igaz,Peter Igaz
Ivan Igaz
Beside blood-borne circulating miRNAs, miRNAs have been identified in other body fluid and excrements including stool, bile, saliva, and urine. Given the direct link of these body fluids to certain organs, their analysis for potential diagn...
Circulating microRNAs in Diabetes Progression: Discovery, Validation, and Research Translation [0.03%]
糖尿病进展中的循环微小核糖核酸：发现、验证与研究转化
Ryan J Farr,Mugdha V Joglekar,Anandwardhan A Hardikar
Ryan J Farr
Diabetes, in all of its forms, is a disease state that demonstrates wide ranging pathological effects throughout the body. Until now, the only method of diagnosing and monitoring the progression of diabetes was through the measurement of bl...
Maria Gazouli
Maria Gazouli
Inflammatory bowel diseases (IBD) are chronic, idiopathic, polygenic diseases with significant genetic heterogeneity. The two major types of IBD are Crohn's disease (CD) and ulcerative colitis (UlC). It is well known that chronic intestinal...
Niels H H Heegaard,Anting Liu Carlsen,Kerstin Skovgaard et al.
Niels H H Heegaard et al.
MicroRNAs (miRNAs) are differentially regulated in healthy, activated, inflamed, neoplastic, or otherwise pathological cells and tissues. While their main functions are executed intracellularly, many miRNAs can reproducibly be detected extr...
Margherita Grasso,Paola Piscopo,Alessio Crestini et al.
Margherita Grasso et al.
Neurodegenerative diseases, such as Alzheimer's disease (AD), Parkinson's disease (PD), and amyotrophic lateral sclerosis (ALS), are caused by a combination of events that impair normal neuronal function. Although they are considered differ...
Salvatore De Rosa,Ciro Indolfi
Salvatore De Rosa
MicroRNAs, key regulators of biological processes, are involved in the pathophysiological mechanisms underlying human diseases, including cardiovascular diseases. Their recent discovery revealed a previously unknown layer of pathophysiologi...