Inês Mesquita,Jérôme Estaquier
Inês Mesquita
Viruses are intracellular parasites that rely on host machinery to replicate and achieve a successful infection. Viruses have evolved to retain a broad range of strategies to manipulate host cell metabolism and metabolic resources, channeli...
Elodie Gazanion,Baptiste Vergnes
Elodie Gazanion
Diseases caused by protozoan parasites have a major impact on world health. These early branching eukaryotes cause significant morbidity and mortality in humans and livestock. During evolution, protozoan parasites have evolved toward comple...
Catarina M Ferreira,Ana Margarida Barbosa,Inês M Pereira et al.
Catarina M Ferreira et al.
The interaction between intracellular bacterial pathogens with the host immune response can result in multiple outcomes that range from asymptomatic clearance to the establishment of infection. At its core, these interactions result in mult...
Metabolomic-Based Methods in Diagnosis and Monitoring Infection Progression [0.03%]
基于代谢组学的方法在感染性疾病诊断和病情监测中的应用
Miguel Fernández-García,David Rojo,Fernanda Rey-Stolle et al.
Miguel Fernández-García et al.
A robust biomarker screening and validation is crucial for overcoming the current limits in the clinical management of infectious diseases. In this chapter, a general workflow for metabolomics is summarized. Subsequently, an overview of the...
Müberra Fatma Cesur,Ecehan Abdik,Ünzile Güven-Gülhan et al.
Müberra Fatma Cesur et al.
A systems approach to elucidate the effect of infection on cell metabolism provides several opportunities from a better understanding of molecular mechanisms to the identification of potential biomarkers and drug targets. This is obvious fr...
Cynthia Soultawi,Yasmina Fortier,Calaiselvy Soundaramourty et al.
Cynthia Soultawi et al.
Microbes have developed a series of strategies to overcome the defense mechanisms of the infected host. During pathogen-host coevolution, they develop strategy to manipulate cellular machinery particularly in subverting mitochondrion functi...
Alterations on Cellular Redox States upon Infection and Implications for Host Cell Homeostasis [0.03%]
感染引起的细胞氧化还原状态的改变及其对宿主细胞稳态的影响
Inês Mesquita,Baptiste Vergnes,Ricardo Silvestre
Inês Mesquita
The cofactors nicotinamide adenine dinucleotide (NAD+) and its phosphate form, NADP+, are crucial molecules present in all living cells. The delicate balance between the oxidized and reduced forms of these molecules is tightly regulated by ...
Prashant Chauhan,Arup Sarkar,Bhaskar Saha
Prashant Chauhan
The immune system, like all other systems, responds to perturbations of the baseline, homeostatic functioning of immune cells. These perturbations come in the form of infection, tumors, autoantigens, and can occur after mismatched transplan...
Stella Maria Barrouin-Melo,Yadira Alejandra Morejón Terán,Johanna Anturaniemi et al.
Stella Maria Barrouin-Melo et al.
Diet plays a fundamental role in the nutritional status, in the homeostasis and in the capacity of an individual to adapt to the environment. A proper or an inadequate nutrition has an impact on the persistence, remission and incidence of v...
Inês Mesquita,Fernando Rodrigues
Inês Mesquita
Metabolism is highly coordinated component of the cellular activity that involves sequential chemical transformations, within a so-called metabolic network. Through these coordinated actions, living organisms acquire energy and biosynthetic...