Multiomics profiles of genome-wide alterations in H3K27ac in different lung lobes after acute graft- versus-host disease with MSCs treatment [0.03%]
急性移植物抗宿主病不同肺叶H3K27ac基因组范围改变的多组学谱型及间充质干细胞治疗后变化规律研究
Zixuan Lu,Yuming Zhou,Chengyu Li et al.
Zixuan Lu et al.
The molecular characteristics of acute graft-versus-host disease (aGVHD) in different lung lobes and the treatment of aGVHD with mesenchymal stem cells are still poorly understood. In addition, despite the important role of acetylation on l...
Specialized pro-resolving mediators in neutrophil apoptosis regulation: unlocking novel therapeutic potential in kidney diseases [0.03%]
中性粒细胞凋亡调节中的专业化解决介质：肾脏疾病新治疗潜力解锁
Yi Kang,Qian Jin,Mengqi Zhou et al.
Yi Kang et al.
Kidney diseases represent a diverse group of disorders with pathogenic mechanisms involving multiple pathological processes, including inflammation, immunity, and cell death. Neutrophils, as primary effector cells in inflammatory immune res...
Case Report: Anti-NMDAR encephalitis associated with neurobrucellosis: causality or coexistence? [0.03%]
个例报告：抗N-甲基-D天冬氨酸受体脑炎与神经布鲁氏病的相关性：因果关系还是共存现象？
Yao Wang,Xue Ma,Chao Ma et al.
Yao Wang et al.
Human brucellosis, caused by Brucella, is an infectious disease with specific endemic regions, especially in pastoral areas, and may affect multiple organ systems. Neurological involvement, namely neurobrucellosis, occurs in very few of the...
Efficacy of MLN9708 (ixazomib) in experimental autoimmune myasthenia gravis and in anti-AChR producing primary thymic cell cultures from myasthenia gravis patients [0.03%]
评估MLN9708（伊沙佐米）对实验性自身免疫型重症肌无力及重症肌无力患者源性原发胸腺细胞系培养物的作用疗效
Marina Mané-Damas,Abhishek Saxena,Gisela Nogales-Gadea et al.
Marina Mané-Damas et al.
Proteasome inhibitors can eliminate malignant, alloreactive, or autoreactive plasma cells. These cells are key players in antibody-mediated autoimmune disorders and thus suitable therapeutic targets for these drugs. However, certain proteas...
Bioinformatics meets machine learning: identifying circulating biomarkers for vitiligo across blood and tissues [0.03%]
生物信息学与机器学习相结合：在血液和组织中识别白癜风的循环生物标志物
Qiyu Wang,Jingwei Yuan,Mengdi Zhang et al.
Qiyu Wang et al.
Background: Vitiligo is a skin disorder characterized by the progressive loss of pigmentation in the skin and mucous membranes. The exact aetiology and pathogenesis of vitiligo remain incompletely understood. ...
TSPAN4+ fibroblasts coordinate metastatic niche assembly through migrasome-driven metabolic reprogramming and stromal-immune crosstalk in pancreatic adenocarcinoma [0.03%]
TSPAN4+成纤维细胞通过迁移体介导的代谢重编程和肿瘤相关基质-免疫细胞串扰在胰腺癌中协调转移微环境组装
Qingwen Hu,Jiali Chen,Yang Liu et al.
Qingwen Hu et al.
Background: Pancreatic cancer (PC) is a highly aggressive pancreatic malignant tumor with poor prognosis due to its complex tumor microenvironment (TME) and metastatic potential. Fibroblasts play an important role in tumo...
Tumor-derived vesicles in immune modulation: focus on signaling pathways [0.03%]
肿瘤来源囊泡与免疫调节：着重于信号转导路径
Fei Yin,Yangfang He,Yue Qiao et al.
Fei Yin et al.
Tumor-derived extracellular vesicles (TDEVs) represent a heterogeneous population of extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, which are essential for tumor growth. EVs function as natural carrie...
An exploratory study on the metagenomic and proteomic characterization of hypothyroidism in the first half of pregnancy and correlation with Th1/Th2 balance [0.03%]
子早期妊娠期甲状腺功能减退的代谢组学及蛋白质组学特征分析及与Th1/Th2平衡相关性探索性研究
Chenchen Zhang,Yajuan Xu,Miao Zhang et al.
Chenchen Zhang et al.
Objective: To explore the gut microbiota and proteomic characteristics of hypothyroidism in the first half of pregnancy (referred to as hypothyroidism in the first half of pregnancy) and its association with Th (T helper ...
Unraveling the immunosuppressive microenvironment of glioblastoma and advancements in treatment [0.03%]
解开胶质母细胞瘤免疫抑制微环境的谜团及治疗进展
Dongxin Jiang,Yunqian Li
Dongxin Jiang
Glioblastoma, the most common and aggressive primary brain tumor, remains a significant challenge in oncology due to its immunosuppressive tumor microenvironment (TME). This review summarizes the complex interplay of immune cells and cytoki...
Bioinformatics analyses of the proteome of Holothuria tubulosa coelomic fluid and the first evidence of primary cilium in coelomocyte cells [0.03%]
海参体液蛋白质组的生物信息学分析及体细胞初级纤毛的首次证据
Laura La Paglia,Manuela Mauro,Vincenzo Arizza et al.
Laura La Paglia et al.
The holothurian immune system is characterized by complex defense mechanisms that act through humoral and cellular pathways. Coelomocites are the cellular component of coelomic fluid, and they are involved in host defense, stress response, ...