Expression of salivary hepcidin and its inducer, interleukin 6 as well as type I interferons are significantly elevated in infants with poor oral rotavirus vaccine take in South Africa [0.03%]
南非较差的口服轮状病毒疫苗接种效果与婴儿唾液中他利珠单抗及其诱导物的表达量显著升高有关
Vusumuzi Mabasa,Mapeseka L Seheri,Cliff A Magwira
Vusumuzi Mabasa
Background: The metabolism of nutritional iron, required by viruses to replicate and proliferate, is regulated by hepcidin, a peptide hormone of 25 amino acids. Overexpression of hepcidin results in iron deficiency anemia...
Jianting Wen,Jian Liu,Lei Wan et al.
Jianting Wen et al.
Rheumatic disease is a chronic inflammatory disease that imposes significant societal and economic burdens. Accumulating evidence has demonstrated that cellular senescence plays an important role in inflammation-induced rheumatic diseases. ...
Strategies for CRISPR-based knock-ins in primary human B cells and lymphoma cell lines [0.03%]
基于CRISPR的初级人类B细胞和淋巴瘤细胞系敲入策略
Sophie Lund,Chun Gong,Xin Yu et al.
Sophie Lund et al.
Since its advent about ten years ago, the CRISPR-Cas9 system has been frequently used in biomedical applications. It has advanced various fields, and CRISPR-Cas9-based therapeutics have shown promising results in the treatment of specific h...
Estrogen and viral infection [0.03%]
雌激素与病毒感染
Xiangrui Wei,Longyan Hong,Hao Liang et al.
Xiangrui Wei et al.
Gender differences exist in the susceptibility, incidence, progression, and prognosis of diseases caused by viral infections. These differences are influenced by various factors, including lifestyle and habits between males and females. Som...
Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy [0.03%]
补体调节紊乱在C3肾小球病中的作用及相关因子H-相关1和肝素硫酸盐的作用机制
Amanda K Slagle,Nicolo Ghiringhelli Borsa,Kai Wang et al.
Amanda K Slagle et al.
Introduction: Dysregulation of the alternative pathway of complement underlies the pathogenesis of C3 glomerulopathy (C3G). Because Factor H (FH) prevents excessive alternative pathway activity while Factor H-related prot...
Metabolic reprogramming in viral infections: the interplay of glucose metabolism and immune responses [0.03%]
病毒感染中的代谢重构：葡萄糖代谢与免疫反应的相互作用
Mahmoud Darweesh,Saeed Mohammadi,Mina Rahmati et al.
Mahmoud Darweesh et al.
Metabolic reprogramming is an important player within the immune response to viral infections, allowing immune cells to fine-tune their energy production and biosynthetic requirements while it is actively working to restrict pathogen access...
Transcutaneous auricular vagus nerve stimulation alleviates inflammation-induced depression by modulating peripheral-central inflammatory cytokines and the NF-κB pathway in rats [0.03%]
经皮耳迷走神经刺激通过调节大鼠外周-中枢炎症细胞因子和NF-κB途径来缓解炎性抑郁病症
Xingke Song,Haohan Zhu,Zijie Chen et al.
Xingke Song et al.
Objectives: This study aims to investigate the mechanisms of transcutaneous auricular vagus nerve stimulation (taVNS) in a lipopolysaccharide (LPS)-induced acute inflammatory depression model in rats, focusing on the regu...
Interplay between cancer-associated fibroblasts and dendritic cells: implications for tumor immunity [0.03%]
癌相关成纤维细胞与树突状细胞间的相互作用：对肿瘤免疫的影响
Fátima María Mentucci,María Gracia Ferrara,Agustina Ercole et al.
Fátima María Mentucci et al.
The tumor microenvironment (TME) plays a critical role in cancer progression, with cancer-associated fibroblasts (CAFs) emerging as key players in immune evasion. This review explores the complex interactions between CAFs and dendritic cell...
Cost-effectiveness analysis of Toripalimab regimen for extensive-stage small-cell lung cancer in China and America [0.03%]
替雷利姆赛布方案治疗广泛期小细胞肺癌的中外成本效益分析
Jing Yang,Fang Chen,Junlin Li et al.
Jing Yang et al.
Objectives: Toripalimab combined with chemotherapy is a clinically valuable and important regimen in the treatment of extensive-stage small-cell lung cancer (ES-SCLC). However, there are no studies on the cost-effectivene...
Reni John,Srinivasu Mudalagiriyappa,Nagabhushan Chandrashekar et al.
Reni John et al.
IL-17A-expressing lymphocytes, including Tc17 cells, are instrumental in immunity, immunopathology, and autoimmunity. We have previously shown that experimental attenuated live fungal vaccine-induced Tc17 cells are stable, long-lived withou...