Fusobacterium nucleatum downregulated MLH1 expression in colorectal cancer by activating autophagy-lysosome pathway [0.03%]
核梭杆菌通过激活自噬溶酶体途径下调结直肠癌中MLH1的表达
Tingting Ding,Minkang Wu,Li Zhao et al.
Tingting Ding et al.
Backgrounds: Fusobacterium nucleatum (F. nucleatum) has been shown to be associated with immunotherapy in colorectal cancer (CRC), but its exact mechanism needs to be further explored. ...
The impact of innate immunity and epigenetics in the pathogenesis of hidradenitis suppurativa [0.03%]
先天免疫和表观遗传学在汗腺炎症发病机制中的影响
Olivia M Burke,Victoria R Frerichs,Dario F Garcia et al.
Olivia M Burke et al.
Hidradenitis Suppurativa (HS) is a chronic multifactorial inflammatory skin disease with a debilitating impact on quality of life. Here, we review the complex interplay of innate and adaptive immune dysregulation in HS pathogenesis, in the ...
Evidence for trans-generational immune priming against Vibrio splendidus in the oyster Crassostrea gigas [0.03%]
太平洋牡蛎对副溶血弧菌的跨世代免疫记忆响应现象研究
Xiaorui Song,Weilin Wang,Miren Dong et al.
Xiaorui Song et al.
Cumulative evidence have demonstrated the occurrence of trans-generational immune priming (TGIP) in invertebrates; however, the detailed substances transferred, and the mechanism of this transmission remain unclear. In the present study, we...
The clinical and socioeconomic aspects of t-cell receptor excision circle based newborn screening for severe combined immunodeficiency in Southeast and East Asia [0.03%]
基于T细胞受体切除环的新生儿严重联合免疫缺陷筛查在东南亚和东亚的临床和社会经济学方面的影响
Noelle Yoo,Seongjin Kim,Jane Kim et al.
Noelle Yoo et al.
Severe Combined Immunodeficiency (SCID) is a widely underdiagnosed congenital disease that is fatal by 2-years old if left untreated. Most cases of SCID are diagnosed from the prompting of family history while other cases are sporadic and h...
Marina Rode von Essen,Marie Mathilde Hansen,Sahla El Mahdaoui et al.
Marina Rode von Essen et al.
Relapsing-remitting multiple sclerosis (RRMS) is a chronic immune-mediated disease of the central nervous system (CNS) characterized by episodic relapses of neurological symptoms. Early diagnosis and treatment of patients is key to prevent ...
Profiling of fecal analytes as a potential biomarker in rheumatoid arthritis [0.03%]
粪便分析物作为类风湿关节炎潜在生物标志物的特征研究
Zhiyi Wang,Yujia Shi,Yachen Yang et al.
Zhiyi Wang et al.
Background: Loss of gut barrier integrity has been observed in rheumatoid arthritis (RA). While systemic inflammation in RA has been extensively investigated, intestinal-specific inflammatory processes remain poorly under...
Bile acid-mediated gut-liver axis crosstalk: the role of nuclear receptor signaling in dynamic regulation of inflammatory networks [0.03%]
胆酸介导的肠道-肝脏轴相互作用：核受体信号在炎症网络动态调节中的作用
Wenlong Yan,Kun Zhang,Jing Guo et al.
Wenlong Yan et al.
Bile acids (BAs) are critical mediators of metabolic and immune regulation, influencing both liver and intestinal function. Their homeostasis, maintained through the enterohepatic circulation, is pivotal for immune-metabolic balance. BAs ac...
Unveiling reverse vaccinology and immunoinformatics toward Saint Louis encephalitis virus: a ray of hope for vaccine development [0.03%]
反向疫苗学和免疫信息学揭示圣路易斯脑炎病毒：疫苗开发的一线希望
Prasanna Srinivasan Ramalingam,Mahalakshmi Aranganathan,Md Sadique Hussain et al.
Prasanna Srinivasan Ramalingam et al.
Introduction: Infectious diseases continue to challenge human health with high incidence and mortality rates worldwide. Notably, the adaptability of RNA viruses, highlighted by outbreaks of SARS, MERS, and COVID-19, empha...
Immune mechanisms mediating the heterologous effects of BCG vaccination: a systematic review [0.03%]
卡介苗接种异源效应的免疫学机制系统综述
Louis Torracinta,Nino Gogichadze,Rachel Tanner
Louis Torracinta
Introduction: BCG vaccination can have heterologous or non-specific effects (NSE) that confer resistance against pathogens other than its target Mycobacterium tuberculosis, but the underlying mechanisms are not fully unde...
Case Report: CD19 CAR-T cells derived from recipient of umbilical cord blood transplantation effectively treated relapsed acute lymphoblastic leukemia after UCBT [0.03%]
病例报告：allo-HSCT后复发B-ALL患者用源自脐带血移植受体的CD19 CAR-T细胞治疗取得良好疗效
Hua Li,Xiaofan Li,Na Xian et al.
Hua Li et al.
Recent advances in chimeric antigen receptors have provided an alternative approach for treating relapsed acute lymphocyte leukemia after allogeneic hematopoietic stem cell transplantation (allo-HSCT). However, relapsed patients who had und...