Aberrant expression of PYGB as a potential therapeutic target and its associations with immune cell infiltration in lung cancer [0.03%]
肺癌中PYGB异常表达作为潜在治疗靶点及其与免疫细胞浸润的关系研究
Kai Sun,De-Chang Xu,Xia Qin et al.
Kai Sun et al.
Background: Brain glycogen phosphorylase (PYGB) facilitates the breakdown of glycogen, thereby supplying energy to tumor cells. While PYGB expression has been documented in various tumor types, its specific function in lu...
Latent tuberculosis coinfection in mild COVID-19 is associated with a distinct immune cell phenotype marked by enhanced cytotoxic degranulation and mitochondrial alterations [0.03%]
潜伏结核感染与轻型新冠肺炎特征性免疫细胞表型有关：胞毒脱颗粒和线粒体改变增强
Carlos Peña-Bates,Lucero A Ramón-Luing,Julio Flores-Gonzalez et al.
Carlos Peña-Bates et al.
Introduction: The chronic nature of latent tuberculosis infection (LTBI) allows it to coexist with diverse pathologies. However, it remains unclear whether immune alterations associated with LTBI influence COVID-19 coinfe...
An immune-related signature based on molecular subtypes for predicting the prognosis and immunotherapy efficacy of hepatocellular carcinoma [0.03%]
基于分子亚型的免疫相关特征在预测肝细胞癌预后和免疫治疗疗效中的作用
Xuhui Sun,Wenlong Jia,Huifang Liang et al.
Xuhui Sun et al.
Background: Immunotherapy has emerged as a pivotal therapeutic modality for a multitude of malignancies, notably hepatocellular carcinoma (HCC). This research endeavors to construct a prognostic signature based on immune-...
Dendritic cell-derived exosomes induce monocyte antigen-presentation and immune amplification in neoantigen vaccine therapy [0.03%]
树突细胞源性外泌体诱导单核细胞抗原呈递并放大新抗原疫苗治疗的免疫反应
Shinji Morisaki,Hideya Onishi,Takafumi Morisaki et al.
Shinji Morisaki et al.
Mature dendritic cells release exosomes; however, the immunological role of exosomes in dendritic cell vaccine therapy remains unclear. We examined the immunogenicity of neoantigen peptide-pulsed dendritic cell-derived exosomes (Neo-P DEX) ...
Targeting myeloid cells in pancreatic ductal adenocarcinoma: from primary tumors to liver metastasis [0.03%]
针对胰腺导管腺癌髓系细胞从原发灶到肝转移的研究
Ruining Gong,Ying Chen,Chang Li et al.
Ruining Gong et al.
Pancreatic ductal adenocarcinoma (PDAC) remains one of the malignancies with the highest mortality rates, and outcomes are particularly poor in cases of liver metastasis. Early or recurrent metastatic PDAC significantly worsens patient outc...
Development and validation of a nomogram for differentiating immune checkpoint inhibitor-related pneumonitis from pneumonia in patients undergoing immunochemotherapy: a multicenter, real-world, retrospective study [0.03%]
预测免疫检查点抑制剂相关肺炎和化疗相关肺炎的列线图模型的开发与验证：一项多中心真实世界回顾性研究
Linli Duan,Guanglu Liu,Zijie Huang et al.
Linli Duan et al.
Background: Immune Checkpoint Inhibitor-related Pneumonitis (CIP) exhibits high morbidity and mortality rates in the real world, often coexisting with pneumonia, particularly after immunochemotherapy. We aimed to develop ...
Multicenter Study
Frontiers in immunology. 2025 May 19:16:1495450. DOI:10.3389/fimmu.2025.1495450 2025
A phase 2a double-blind, placebo-controlled, randomized clinical trial evaluating the efficacy and safety of NuGel, a novel topical GPCR19-mediated inflammasome inhibitor, in patients with mild to moderate atopic dermatitis: a proof-of-concept study with Post-hoc biomarker analysis [0.03%]
NuGel（一种新型GPCR19介导的炎性小体抑制剂药膏）治疗轻中度特应性皮炎有效性和安全性的双盲安慰剂对照随机IIa期临床试验——基于生物标志物分析的概念验证研究
Gyeong Ho Baek,Bo Ri Kim,Jung-Won Shin et al.
Gyeong Ho Baek et al.
Background: Current guidelines to treat atopic dermatitis (AD) overlook disease heterogeneity, limiting personalized care. This study assessed NuGel, a topical GPCR19 agonist, for efficacy, safety, and predictive baseline...
Clinical Trial
Frontiers in immunology. 2025 May 19:16:1560447. DOI:10.3389/fimmu.2025.1560447 2025
Two major human phenotypes of MICA molecules and their differential activation to NK cells via NKG2D receptor [0.03%]
MICA分子的两种主要人类表型及其通过NKG2D受体对NK细胞的不同激活作用
Qizhi Luo,Xiangli Yin,Quan Zhu et al.
Qizhi Luo et al.
Introduction: The major histocompatibility complex class I-related gene A (MICA), is a highly polymorphic gene, serve as a crucial role in immune regulator through its interaction with the NKG2D receptor on natural killer...
TLR4 and prostaglandin pathways at the crossroads of endotoxemia-induced lipolysis [0.03%]
TLR4和前列腺素途径在内毒素诱导的脂解交叉点上的作用
Miguel Chirivi,Ursula Abou-Rjeileh,Madison Myers et al.
Miguel Chirivi et al.
Background: During endotoxemia, immune activation rapidly increases energy needs. To meet these demands, white adipose tissue (WAT) mobilizes fatty acids through lipolysis. While fatty acids serve as energy-dense substrat...