Succinylation-related molecular activities in cancer: metabolic adaptations, immune landscape, and prognostic significance in colorectal cancer [0.03%]
丙二酰化相关分子在癌症中的作用：代谢适应、免疫图谱及结直肠癌预后意义
Zhihang Jiang,Xiaoqing Li,Long Hu et al.
Zhihang Jiang et al.
Background: Succinylation, a key post-translational modification, plays a crucial role in metabolic regulation and tumor progression. However, its influence on the tumor immune microenvironment and its prognostic implicat...
Translational insights from EAE models : decoding MOGAD pathogenesis and therapeutic innovation [0.03%]
从自身免疫性脑脊髓炎模型获得的转化见解：解码MOGAD发病机制和治疗创新
Yanjia Zhang,Dong Li
Yanjia Zhang
Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease (MOGAD) is a rare acquired demyelinating syndrome manifesting as optic neuritis (ON), transverse myelitis (TM), acute disseminated encephalomyelitis (ADEM), and brainstem encep...
Reverse vaccinology-based design of multivalent multiepitope mRNA vaccines targeting key viral proteins of Herpes Simplex Virus type-2 [0.03%]
基于逆向疫苗学设计的针对HSV-2关键蛋白的多价多抗原mRNA疫苗
N S Suneesh,Kishore Dhotre,Pratik Mahajan et al.
N S Suneesh et al.
Introduction: Herpes Simplex Virus type 2 or HSV-2 is a major cause of genital herpes, contributing to increased susceptibility to HIV, encephalitis, and other severe complications. Despite the availability of antiviral t...
Efficacy of neoadjuvant, adjuvant, and perioperative immunotherapy in non-small cell lung cancer across different PD-L1 expression levels: a systematic review and meta-analysis [0.03%]
基于PD-L1表达水平的非小细胞肺癌新辅助、辅助及围手术期免疫治疗疗效的系统评价和meta分析
Zhenlong Zhang,Yuchen Lin,Shuchen Chen
Zhenlong Zhang
Background: Immune checkpoint inhibitors, particularly anti-PD-1/PD-L1 monoclonal antibodies, have transformed non-small cell lung cancer (NSCLC) treatment. This meta-analysis evaluates the efficacy of neoadjuvant, adjuva...
Integration of hepatic lipidomics and transcriptomics reveals dysregulation of lipid metabolism in a golden hamster model of visceral leishmaniasis [0.03%]
肝脂质组学和转录组学的整合揭示了金仓鼠腹腔利什曼病模型中脂质代谢的失调现象
Dongmei Yuan,Hanxiao Qin,Zeying Yu
Dongmei Yuan
Visceral leishmaniasis (VL), the most severe form of leishmaniasis, remains a significant public health concern that cannot be overlooked in underdeveloped regions. Studies suggest that lipids play a crucial role in the survival of Leishman...
Single-cell transcriptomics reveals cellular dynamics and chemokine CXCL2-mediated smooth muscle cell proliferation in arterial repair [0.03%]
单细胞转录组揭示动脉修复中CXCL2介导的平滑肌细胞增殖现象
Xingxiao Huang,Yan Ping,Qiuli Sun et al.
Xingxiao Huang et al.
Background: Percutaneous coronary intervention (PCI) remains the primary treatment for coronary artery disease (CAD), yet post-procedural arterial injury triggers cellular change and pathological inflammation, leading to ...
An integrated mutation-based immunoinformatic approach incorporating variability in epitopes: a study based on HIV subtype C [0.03%]
一种基于免疫信息学的集成突变方法，结合表位中的可变性：以HIV亚型C为例的研究
Saurav Kumar Mishra,Neeraj Kumar,Md Harun Or Rashid et al.
Saurav Kumar Mishra et al.
Currently, HIV (human immunodeficiency virus) infection is one of the leading complications in public health and causes acquired immunodeficiency syndrome (AIDS), especially in the African region. No specific vaccine is available to combat ...
Addressing SARS-CoV-2 evolution: neutralization of emerging variants of concern by the AVX/COVID-12 'Patria' vaccine based on HexaPro-S ancestral Wuhan spike or its updated BA.2.75.2 version [0.03%]
应对SARS-CoV-2的进化：基于HexaPro-S（旧版武汉谱系）或BA.2.75.2更新版本“Patria”新冠候选疫苗AVX/COVID-12对关切变异株的中和作用
Gregorio Carballo-Uicab,Gabriela Mellado-Sánchez,Edith González-González et al.
Gregorio Carballo-Uicab et al.
Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains a global health challenge, causing severe morbidity and mortality, particularly in vulnerable groups such as the elderly, immunocompromise...
Fatal HLH in patients with X-linked lymphoproliferative disease 1 due to a novel variant in SH2D1A: case report [0.03%]
SH2D1A新型变异所致X连锁淋巴增生综合征1患者的致命噬血细胞综合征：病例报告
Oksana Boyarchuk,Alla Volokha,Nataliia Yarema et al.
Oksana Boyarchuk et al.
Introduction: X-linked lymphoproliferative disease type 1 (XLP1) is an inborn error of immunity (IEI) caused by pathogenic variants in the SH2D1A gene, leading to severe immune dysregulation, often triggered by Epstein-Ba...
The protein interaction of mitochondrial transcription factors A and B2 is associated with 30-day survival in critical COVID-19 [0.03%]
线粒体转录因子A和B2的蛋白质相互作用与重度COVID-19患者30天生存率相关
Britta Westhus,Patrick Thon,Lars Palmowski et al.
Britta Westhus et al.
Introduction: Repair of mitochondrial damage seems pivotal for clinical recovery and determining outcome in patients with critical COVID-19. However, reliable biomarkers for non-invasively assessing mitochondrial repair i...
Multicenter Study
Frontiers in immunology. 2025 May 16:16:1445403. DOI:10.3389/fimmu.2025.1445403 2025