Editorial: The liver's dilemma: sensing real danger in a sea of PAMPs [0.03%]
述评：肝脏的两难境地：在茫茫PAMPs中感知真正的危险
Ian N Crispe,Andrea Henriques Pons
Ian N Crispe
Multiple gastric tumors in patients with combined autoimmune and helicobacter pylori-associated gastritis: a case report and literature review [0.03%]
自身免疫及幽门螺旋杆菌相关胃炎患者并发多发性胃肿瘤的病例报道及文献复习
Wulian Lin,Cuiling Wu,Guilin Xu et al.
Wulian Lin et al.
This paper presents four cases of autoimmune gastritis coexisting with Helicobacter pylori- associated gastritis, all of which developed gastric tumors, with some cases exhibiting multiple histological origins. Through a narrative literatur...
Single-cell RNA sequencing identifies two fibroblast subtypes and a Trem2+ macrophage subtype as the possible specific cellular targets in abdominal aortic aneurysms [0.03%]
单细胞RNA测序鉴定腹主动脉瘤的两个成纤维细胞亚群和Trem2+巨噬细胞亚群为可能的特定靶细胞类型
Zhili Liu,Xiaojun Song,Ben Wang et al.
Zhili Liu et al.
Background: Aortic aneurysm is a potentially fatal condition. Although contemporary studies have established that this disease triggers an inflammatory response, reduces smooth muscle cells, and induces extracellular matr...
B and T lymphocyte attenuator (BTLA) and PD-1 pathway dual blockade promotes antitumor immune responses by reversing CD8+ T-cell exhaustion in non-small cell lung cancer [0.03%]
B和T淋巴细胞活化调节剂（BTLA）和PD-1通路双重阻断通过逆转非小细胞肺癌中CD8+T细胞的耗竭来促进抗肿瘤免疫反应
Yang Zhang,Yang Yang,Yuanyuan Zeng et al.
Yang Zhang et al.
Background: Immunotherapies targeting the programmed cell death 1 (PD-1)/programmed death ligand 1 (PD-L1) have shown great promise for a subset of patients with non-small cell lung cancer (NSCLC). However, safe and robus...
Commentary: Guselkumab binding to CD64+ IL-23-producing myeloid cells enhances potency for neutralizing IL-23 signaling [0.03%]
评论： Guselkumab 与 CD64+IL-23 分泌型髓系细胞结合，增强了对 IL-23 信号通路的抑制作用
Giulia Valdiserra,Clelia Di Salvo,Matteo Fornai et al.
Giulia Valdiserra et al.
SIV/SARS-CoV-2 coinfection in rhesus macaques impacts viral shedding, host immunity, the microbiome, and viral evolution [0.03%]
猪笼草/SARS-CoV-2共感染影响了恒河猴的病毒脱落、宿主免疫性、微生物组及病毒进化
Megan N Fredericks,Zohar Kolodner,Adam Waalkes et al.
Megan N Fredericks et al.
People living with HIV (PLWH) have an increased risk of severe COVID-19, including prolonged viral shedding and emergence of mutations. To investigate the simian immunodeficiency virus (SIV) macaque model for HIV/SARS-CoV-2 coinfection, sev...
Influence of programmed death ligand 1 (PD-L1) knockout on gut microbiota in experimental autoimmune uveitis [0.03%]
程序性死亡配体1(PD-L1)基因敲除对实验性自身免疫性葡萄膜炎小鼠肠道菌群的影响研究
Junxiang Gu,Yixian Ma,Qing Chang et al.
Junxiang Gu et al.
Purpose: Programmed death ligand 1 (PD-L1) is a potential target for autoimmune disease therapies. The gut microbiota plays a critical role in autoimmunity, and may influence therapeutic outcomes of immune therapies in ca...
Humoral and cellular immune responses in cattle upon Clostridium chauvoei vaccination and challenge [0.03%]
牛破伤风疫苗接种和攻毒后的体液免疫和细胞免疫反应
Andrea Rossi,Julio Guarnaschelli,Analía Rial et al.
Andrea Rossi et al.
Introduction: Clostridium chauvoei is the causative agent of blackleg, a severe disease in cattle. Vaccination reduces disease incidence but the immune mechanisms that underlie vaccine-induced protection remain poorly und...
Construction of a prognostic model for endometrial cancer related to programmed cell death using WGCNA and machine learning algorithms [0.03%]
基于WGCNA和机器学习算法的构建与程序性细胞死亡相关的子宫内膜癌预后模型
Weicheng Pan,Jinlian Cheng,Shanshan Lin et al.
Weicheng Pan et al.
Background: Programmed cell death (PCD) refers to a regulated and active process of cellular demise, initiated by specific biological signals. PCD plays a crucial role in the development, progression, and drug resistance ...
Research and progress of cGAS/STING/NLRP3 signaling pathway: a mini review [0.03%]
cGAS/STING/NLRP3信号通路的研究进展：一篇简评
Ke-Qian Chen,Wen-Rui Tang,Xiang Liu
Ke-Qian Chen
Over the past decade, inflammasome and cGAS-STING have received significant attention as immune components that coordinate host immune homeostasis. Although the inflammasome and cGAS-STING are relatively independent immune signaling pathway...