Aqueous humor cytokines levels and illuminated microcatheter-assisted circumferential trabeculotomy outcome in open-angle glaucoma patients: a 24-month prospective study [0.03%]
房水细胞因子水平与光导束辅助周边小梁切开术治疗开角型青光眼患者的疗效：一项为期24个月的前瞻性研究
Tingyi Wu,Qianqian Ji,Yanfeng Liao et al.
Tingyi Wu et al.
Purpose: To investigate the influence of aqueous humor cytokines levels on the failure of illuminated microcatheter-assisted circumferential trabeculotomy (MAT) in open-angle glaucoma (OAG) patients. ...
Distribution and potential involvement of PTEN in the innate immune response during viral infections in Cherry Valley ducks [0.03%]
PTEN在病毒性感染樱桃谷鸭固有免疫反应中的分布及可能作用机制研究
Wende Chen,Shaojie Han,Rong Li et al.
Wende Chen et al.
Introduction: Phosphatase and tensin homolog (PTEN) is a well-established tumor suppressor gene that antagonizes the PI3K/AKT signaling pathway and plays a critical role in regulating both innate and adaptive immune respo...
Development of caninized anti-CTLA-4 antibody as salvage combination therapy for anti-PD-L1 refractory tumors in dogs [0.03%]
开发犬源化抗CTLA-4抗体作为难治性抗PD-L1肿瘤的补救联合疗法
Naoya Maekawa,Satoru Konnai,Kei Watari et al.
Naoya Maekawa et al.
Immune checkpoint inhibitors (ICIs) are widely used for cancer immunotherapy; however, the clinical efficacy of anti-PD-1/PD-L1 monotherapy is generally limited, highlighting the need to develop combination therapies. Dogs develop spontaneo...
Impact of human leukocyte antigen mismatch between donor-recipient on acute rejection in liver transplantation using next-generation sequencing: a single-center study [0.03%]
基于高通量测序的肝移植供受者HLA配型与急性排斥反应的关系研究
Genjie Lu,Yangfang Lu,Yanmin He et al.
Genjie Lu et al.
Background: The effect of human leukocyte antigen (HLA) mismatch on acute rejection (AR) in liver transplantation (LT) is controversial. This study aimed to investigate the effect of donor-recipient mismatch at the HLA-A,...
AI-driven multi-omics profiling of sepsis immunity in the digestive system [0.03%]
人工智能驱动的消化系统感染免疫多组学分析
Yuan Gao,Hong Chen,Ruolan Wu et al.
Yuan Gao et al.
Sepsis is a life-threatening systemic inflammatory syndrome characterized by a complex immune biphasic imbalance. Monitoring of immune status has not yet been implemented in clinical practice due to lack of direct therapeutic utility. Immun...
Fc-effector functional antibody assays for SARS-CoV-2 variants of concern [0.03%]
关注SARS-CoV-2关切变异株的效应者功能性抗体检测方法评估
Xuemin Chen,Grace Li,Caroline Ciric et al.
Xuemin Chen et al.
Background: The Fc regions of antibodies mediate important effector cell functions such as antibody-dependent cellular cytotoxicity (ADCC), antibody-dependent cellular phagocytosis (ADCP), antibody-dependent neutrophil ph...
Exploring the standardized detection and sampling methods of human nasal SARS-CoV-2 RBD IgA [0.03%]
人鼻SARS-CoV-2 RBD IgA的标准化检测与采样方法探索
Xuanxuan Zhang,Jizong Jia,Chaoying Hu et al.
Xuanxuan Zhang et al.
Introduction: Vaccines capable of effectively inducing mucosal immunity, particularly specific IgA antibodies, represent an ideal strategy for preventing infections and the transmission of pathogens such as SARS-CoV-2 and...
Where there's smoke, there's fire: insights from murine models on the effect of cigarette smoke in rheumatoid arthritis development [0.03%]
有烟必有火：小鼠模型对吸烟与类风湿关节炎发病机制关系的见解
Courtney Lynn Marshall,Mahadevappa Hemshekhar,Neeloffer Mookherjee et al.
Courtney Lynn Marshall et al.
Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by joint inflammation and damage, leading to disability and pain. The etiology of RA is undefined but considered multifactorial, as interactions between ge...
Cross-talk between cardiac lymphatics and immune cells regulates inflammatory response and cardiac recovery after myocardial infarction [0.03%]
心脏淋巴管与免疫细胞之间的串话调节心肌梗死后炎症反应和心脏恢复
Zhihua Yang,Zeyu Zhang,Shaoling Feng et al.
Zhihua Yang et al.
Myocardial infarction (MI) is a life-threatening disease with high morbidity and mortality, closely associated with immune-inflammatory responses. As essential pathways for immune cell clearance and interstitial fluid drainage, lymphatic ve...
Crosstalk between metabolic reprogramming and microbiota: implications for cancer progression and novel therapeutic opportunities [0.03%]
代谢重组与微生物群之间的串扰：对癌症进展和新型治疗机会的意义
Xingchen Li,Yidi Jia,Yanqing Li et al.
Xingchen Li et al.
Metabolic reprogramming is a process by which cells adapt to the nutrient microenvironment by regulating energy metabolism. Compared with normal cells, tumor cells tend to undergo metabolic reprogramming, which is one of the hallmarks of co...