The efficacy and safety of adjuvant immunotherapy after neoadjuvant immunotherapy combined with chemotherapy in locally advanced resectable esophageal squamous cell carcinoma: a real-world study [0.03%]
新辅助免疫治疗联合化疗后的辅助免疫治疗用于局部晚期可切除食管鳞癌的疗效及安全性：一项真实世界研究
Xue Wu,Fangjie Ding,Shunshun Bao et al.
Xue Wu et al.
Background: The promising therapeutic outcomes of neoadjuvant immunotherapy with chemotherapy (NAIC) in the treatment of resectable locally advanced esophageal squamous cell carcinoma (LA-ESCC) have been confirmed by seve...
Pretreatment CALLY index as promising novel biomarker in the prediction of surgical and oncological outcomes in esophageal cancer: a multi-center retrospective cohort study [0.03%]
预处理CALLY指数有望成为预测食管癌外科和肿瘤学结果的新型生物标志物：一项多中心回顾性队列研究
Peize Meng,Tongtong Gu,Jiayong Xu et al.
Peize Meng et al.
Background: Esophageal cancer (EC) is a global health challenge with high mortality rates. The traditional TNM staging system is limited in its ability to provide accurate prognostic predictions. This study aimed to inves...
Multicenter Study
Frontiers in immunology. 2025 May 21:16:1605067. DOI:10.3389/fimmu.2025.1605067 2025
Updated overall survival data and predictive biomarkers of autologous NK cells plus Sintilimab as second-line treatment for advanced non-small cell lung cancer [0.03%]
抗原递呈增强型天然杀伤细胞联合信迪利单抗治疗晚期非小细胞肺癌的更新后总生存数据及其预测生物标志物研究
Lin Jia,Naifei Chen,Xiao Chen et al.
Lin Jia et al.
Purpose: Combination strategies involving immune checkpoint inhibitors (ICIs) have been a prominent focus of research in the treatment of non-small cell lung cancer (NSCLC). Our prior findings demonstrated that the combin...
Pei Zhang,Kai-Li Shi,Chun-Lin Gao et al.
Pei Zhang et al.
Anti-glomerular basement membrane glomerulonephritis (anti-GBM GN) is a rare autoimmune disease that often progresses to end-stage renal disease (ESRD). Complement activation and anti-GBM GN are closely related, as evidenced by the renal pa...
Sibusiso Luthuli,Jiazhu Wu,Xin Zhou
Sibusiso Luthuli
Clinical and pathological analysis of indolent T-cell lymphoproliferative disease of the gastrointestinal tract [0.03%]
胃肠道惰性T细胞淋巴增生性疾病临床病理分析
Dan Yuan,Na Liang,Dong-Yue Wang et al.
Dan Yuan et al.
Objective: This study aimed to investigate the clinicopathological features of indolent T-cell lymphoproliferative disease of the gastrointestinal tract (ITLPD-GI) and to improve its diagnostic and therapeutic approaches....
The significance of reactive oxygen species in the formation of calcium oxalate stones and the protective effects of antioxidants on the kidneys [0.03%]
反应氧自由基在草酸钙结石形成中的作用及抗氧化剂的肾脏保护效应的意义
XiaoLong Ying,Yang Chen,ZongYao Hao et al.
XiaoLong Ying et al.
Exposure of renal tubular epithelial cells (RTCs) to kidney stones or calcium oxide crystals triggers the production of reactive oxygen species (ROS), leading to oxidative stress. This oxidative milieu incites cellular injury and elicits an...
CAR-T cell therapy clinical trials: global progress, challenges, and future directions from ClinicalTrials.gov insights [0.03%]
CAR-T细胞治疗临床试验：来自ClinicalTrials. gov的全球进展、挑战与未来方向透视分析
Li-Ya Cao,Yue Zhao,Yang Chen et al.
Li-Ya Cao et al.
Chimeric antigen receptor T (CAR-T) cell therapy has undergone vigorous development in recent years, yet it still faces significant challenges and difficulties in its clinical application and further development. A systematic synthesis of g...
Single-cell transcriptomics in colorectal cancer uncover the potential of metastasis and immune dysregulation of a cell cluster overexpressed PRSS22 [0.03%]
单细胞转录组揭示结直肠癌中一个高表达PRSS22的细胞簇潜在的转移能力及免疫失调性
Chengyuan Xu,Ziheng Zhou,Dongfei Zhu et al.
Chengyuan Xu et al.
Background: Colorectal cancer (CRC) is one of the most common malignancies worldwide, and its complex pathogenesis and significant tumor cell heterogeneity remain major challenges. With the rapid development of single-cel...
Joseph Hutton,Wenrui Sun,Tetsuo Hasegawa
Joseph Hutton
Macrophages are essential components of all body tissues, including the synovium. Tissue macrophages originate either from embryonically seeded "primitive" macrophages or from bone marrow-derived monocytes. In adults, both sources contribut...