Osteoclast-like multinucleated giant cells reinforce polycaprolactone grafts [0.03%]
类似破骨细胞的多核巨噬细胞增强聚己内酯移植物的功能
Halldór Bjarki Einarsson,Anders Frisk Mortensen,Morten Schallburg Nielsen et al.
Halldór Bjarki Einarsson et al.
Successful application of advanced engineered materials in osteoplasty requires a biological understanding of the recipient reaction. The immune system acts like a double-edged sword by maintaining targeted tissue and rejecting grafts. Neve...
Leveraging immune checkpoint inhibitors in lung cancer patients with pre-existing autoimmune disease: clinical insights, optimal timing, and predictive biomarkers for optimal treatment outcomes [0.03%]
免疫检查点抑制剂在伴有自身免疫性疾病的肺癌患者中的应用：临床见解、最佳治疗时机及预测生物标志物以实现最优疗效
Hui Yang,Sheng Yu,Hong Ge
Hui Yang
The use of immune checkpoint inhibitors (ICIs) has revolutionized cancer treatment, particularly in lung cancer. However, their use in patients with pre-existing autoimmune diseases (PADs) presents unique challenges. PADs, such as rheumatoi...
Prime-boost vaccination with chimeric antigens adjuvanted in Montanide™ ISA50 V2 confers protection against experimental Lepeophtheirus salmonis infestation in Atlantic salmon (Salmo salar L.) [0.03%]
基于嵌合抗原的基因工程疫苗对三文鱼海虱病的免疫防护作用研究
Alianet Rodríguez,Koestan Gadan,Lincidio Pérez et al.
Alianet Rodríguez et al.
Introduction: Sea lice are crustacean ectoparasites affecting Atlantic salmon production worldwide and impediments to industry growth. Chemical treatment has been the method of choice to control infestation with increasin...
Neurexin-3a IgG-mediated autoimmune encephalitis: a case report and literature review [0.03%]
神经蛋白-neurexin-3a免疫球蛋白G介导的自身免疫性脑炎1例报告及文献复习
Pin Wang,Lin Sun,Yan Wei et al.
Pin Wang et al.
We summarized the clinical manifestations, auxiliary examinations, treatment, and prognostic characteristics of a patient with neurexin-3a IgG-mediated autoimmune encephalitis. On March 2, 2024, a 43-year-old male patient was admitted to th...
Neuroinflammation associated with proviral DNA persists in the brain of virally suppressed people with HIV [0.03%]
与潜伏病毒DNA相关的神经炎症持续存在于有效抑制的艾滋病患者的大脑中
Sarah J Byrnes,Janna Jamal Eddine,Jingling Zhou et al.
Sarah J Byrnes et al.
Despite viral suppression with antiretroviral therapy (ART), people with HIV (PWH) continue to exhibit brain pathology, and ~20% of individuals develop HIV-associated neurocognitive disorders. However, the state of cellular activation in th...
Clinical benefits of immune checkpoint inhibitors for malignant peripheral nerve sheath tumors with NF2 mutation: a case report [0.03%]
免疫检查点抑制剂治疗NF2基因突变的恶性外周神经鞘瘤1例及其临床获益
Yale Jiang,Guo Zhao,Qiyu Tang et al.
Yale Jiang et al.
Background: Malignant peripheral nerve sheath tumors (MPNSTs), which arise from peripheral nerves or cells associated with nerve sheaths, are uncommon and biologically aggressive sarcomas. Currently, immune checkpoint inh...
Emerging immunotherapy and tumor microenvironment for advanced sarcoma: a comprehensive review [0.03%]
晚期软组织肉瘤的免疫治疗和肿瘤微环境的全面综述
Hai Huang,Yiwei Fan,Shuling Zhang et al.
Hai Huang et al.
Sarcomas are heterogeneous mesenchymal malignancies classified as soft-tissue sarcomas (STS) and bone sarcomas. Advanced cases respond poorly to standard therapies, highlighting the need for novel strategies. Immunotherapies, including PD-1...
Ultra-sensitive in situ detection of intracellular Mycobacterium tuberculosis with CRISPR/Cas12a [0.03%]
具有超高灵敏度的CRISPR/Cas12a结核分枝杆菌胞内检测技术
Zhiqiang Lin,Zhe Song,Hong Yu et al.
Zhiqiang Lin et al.
Mycobacterium tuberculosis (Mtb) invades and survives inside macrophages, evading detection and resisting antibiotic treatment, which results in severe clinical consequences such as fatal respiratory failure and systemic inflammation. Rapid...
Spatial immune profiling reveals distinct microenvironments in medullary thyroid carcinoma [0.03%]
空间免疫谱分析揭示了髓样甲状腺癌中的不同微环境
Maria Eduarda de Castro,Gustavo Forlin de Siqueira,Jean Ferrante Mariano et al.
Maria Eduarda de Castro et al.
Introduction: Medullary thyroid carcinoma (MTC) is a rare and aggressive thyroid cancer with a challenging prognosis. While the immune microenvironment plays a crucial role in cancer progression, its role in MTC remains u...
Neutrophil extracellular traps in central nervous system disorders: mechanisms, implications, and emerging perspective [0.03%]
中枢神经系统疾病中的中性粒细胞胞外诱捕网：机制、影响及展望
Shan Qiao,Jing Yuan,Shan-Chao Zhang et al.
Shan Qiao et al.
Neutrophil Extracellular Traps (NETs), as a crucial defense mechanism of neutrophils, have garnered increasing attention in recent years for their roles in central nervous system (CNS) disorders. This review comprehensively summarizes the f...