Case Report: Vanishing bile duct syndrome in Hodgkin's lymphoma: a case highlighting jaundice and lymphadenopathy as early clues [0.03%]
霍奇金淋巴瘤并发肝内胆管消失综合征1例报告
Shiyu Ma,Dali Cai,Yuan Miao et al.
Shiyu Ma et al.
Vanishing bile duct syndrome is a specific pathologic process characterized by ductopenia and intrahepatic cholestasis, which may be a unique paraneoplastic syndrome of Hodgkin's lymphoma with an unfavorable prognosis. We report a 34-year-o...
Combined treatment with anti-PSMA antibody and human peripheral blood-derived NK cells for castration-resistant prostate cancer [0.03%]
联合使用抗PSMA抗体和人外周血来源的NK细胞治疗去势抵抗性前列腺癌
Fangming Wang,Nianzeng Xing,Jianxing Li
Fangming Wang
Background: Castration-resistant prostate cancer (CRPC) has a poor prognosis and requires novel therapeutic approaches. Previously, we discovered that a high dose of human peripheral blood-derived natural killer (PB-NK) c...
Toward precision oncology in LUAD: a prognostic model using single-cell sequencing and WGCNA based on a disulfidptosis relative gene signature [0.03%]
基于二硫基质蛋白酶相关基因特征的LUAD预后模型：走向精准肿瘤学
Panpan Li,Han Zhang,Limin Sun et al.
Panpan Li et al.
Background: Disulfidptosis, a recently identified mechanism of cell death characterized by intracellular sulfide accumulation, leading to cellular exhaustion. Our objective is to create a prognostic model using a cohort o...
Malakoplakia mimicking malignant rectal carcinoma with bone erosion in a SLE patient: diagnosis insights from a case report and literature review [0.03%]
系统性红斑狼疮患者溃疡性小肠结肠炎并发马尔托普拉基亚1例报告及文献复习
Lingshu Zhang,Jingyao Zhang,Ji Wen et al.
Lingshu Zhang et al.
Malakoplakia, an uncommon granulomatous inflammatory disease, is frequently associated with impaired immune function in adults, and its occurrence in patients with systemic autoimmune diseases such as SLE has not been widely studied. The va...
Comprehensive analysis of the functional and immunological significance of ETV4 in pan-cancer and its validation in digestive tumors [0.03%]
ETV4在泛癌中的功能及免疫学意义的全面分析及其在消化系统肿瘤中验证
Lingli Huang,Xujia Li,Silan Huang et al.
Lingli Huang et al.
Background: The E26 transformation-specific (ETS) transcription factor family is widely expressed and implicated in tumorigenesis. Among them, ETV4 plays a crucial role in cancer progression. However, its broader impact o...
Methods integrating innate and adaptive immune responses in human in vitro immunization assays [0.03%]
一种整合固有免疫和适应性免疫反应的人体In vitro免疫检测方法
Tetiana Y Bowley,Kiersten D Lenz,Apoorv Shanker et al.
Tetiana Y Bowley et al.
Rapid vaccine development and innovative immunotherapeutics are critical in the fight against emerging outbreaks and global pandemic threats, yet the high costs and prolonged timelines for developing new vaccines underscore the urgent need ...
Advancements and challenges in immunotherapy for gastric cancer: current approaches and future directions [0.03%]
胃癌免疫治疗进展与挑战：现状及未来方向
Wenyu Zhang,Jingzheng Chen,Zehao Wei et al.
Wenyu Zhang et al.
Gastric cancer (GC) poses a major global health challenge, marked by high incidence and mortality rates. Conventional treatments such as surgery, chemotherapy, and targeted therapies show limited effectiveness in patients at advanced stages...
The role of RNA methylation in glioma progression: mechanisms, diagnostic implications, and therapeutic value [0.03%]
RNA甲基化在胶质瘤发生发展中的作用：机制、诊断价值和治疗意义
Shao-Ze Zhang,Shao-Yan Liu,Meng-Die Cheng et al.
Shao-Ze Zhang et al.
Glioma represents a highly lethal form of malignant tumour, with RNA methylation emerging as a critical regulator of its oncogenesis and progression. As a prevalent post-translational modification, methylation influences various biological ...
Zainab Jan,Farah El Assadi,Dinesh Velayutham et al.
Zainab Jan et al.
Tumor necrosis factor alpha inhibitors (TNFi) are biologic drugs that target TNFα, a key pro-inflammatory cytokine, to suppress disease activity and alleviate symptoms of various autoimmune diseases, including inflammatory bowel disease. T...
Dissecting the dual role of OTU family proteins in tumor progression and immune escape [0.03%]
探究OTU蛋白家族在肿瘤发生发展及免疫逃逸中的双重作用机制
Xiaolong Tang,Yadan Li,Yongshuo Liu
Xiaolong Tang
As a core mechanism regulating intracellular protein homeostasis, the dynamic equilibrium between ubiquitination and deubiquitination profoundly impacts the functionality and fate of target proteins. The Ovarian tumor domain (OTU) family, a...