A new 3-arylbenzofuran derivative EIE-2 reestablishes Treg-dependent tolerance in rheumatoid arthritis by targeting on Syk induced mTOR and PKCθ imbalance [0.03%]
新型3-芳基苯并呋喃衍生物EIE-2通过靶向Syk调控的mTOR和PKCθ失衡在类风湿关节炎中重塑Tregs依赖性耐受性
Ping Li,Xin Yin,Xinzhu Wen et al.
Ping Li et al.
Introduction: Dysfunctional self-tolerance is thought to play a crucial role in the onset of rheumatoid arthritis (RA) pathogenesis. Poorly functioning regulatory T cells (Tregs) lead to extreme situations where self-tole...
Antibody-drug conjugates in cancer therapy: applications and future advances [0.03%]
抗体-药物偶联物在癌症治疗中的应用及未来进展
Rou Long,Hanrong Zuo,Guiyang Tang et al.
Rou Long et al.
Antibody-Drug Conjugates (ADCs) represent an emerging cancer therapeutic strategy and are becoming increasingly significant in the field of public health. With the evolution of precision oncology, the potential applications of ADCs are bein...
Ji-Seung Yoo,Oron Zvi Shporn,Ella H Sklan
Ji-Seung Yoo
Life-threatening severe dengue (SD) develops in a small subset of patients suffering from dengue fever (DF), a febrile disease that develops following infection with dengue virus (DENV). DENV is a mosquito-borne positive -sense RNA virus. T...
Alleviating effect of vine tea on Aeromonas hydrophila infection revealed by small RNA transcriptome analyses of loach liver [0.03%]
基于苦瓜茶的小RNA转录组分析揭示其对鳗鲡细菌性败血症的缓解作用
Wenqing Lai,Yuqin Qiu,Shengnan Pan et al.
Wenqing Lai et al.
Vine tea (Ampelopsis grossedentata) is a widely used Chinese herb with a long history of application in southern China, known for its notable anti-infective, antibacterial and immunomodulatory pharmacological properties. It has potential fo...
Research progress on HER2-specific chimeric antigen receptor T cells for immunotherapy of solid tumors [0.03%]
HER2特异性嵌合抗原受体T细胞治疗实体肿瘤研究进展
Liaoliao Zhu,Jingyi Liu,Junqiang Li et al.
Liaoliao Zhu et al.
Human epidermal growth factor receptor 2 (HER2) is highly expressed in various solid tumors, and its abnormal activation is closely associated with poor tumor prognosis, establishing it as a prominent target in contemporary research. The su...
Ferroptosis in idiopathic pulmonary fibrosis: mechanisms, impact, and therapeutic opportunities [0.03%]
特发性肺纤维化中的铁死亡：机制、影响和治疗机会
Mingjun Yao,Zheng Liu,Wei Zhao et al.
Mingjun Yao et al.
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease characterized by progressive scarring, alveolar destruction, and limited therapeutic options. Although the exact etiology of IPF remains unclear, emerging evidence sug...
The impact of immune checkpoint inhibitors on prognosis in unresectable hepatocellular carcinoma treated with TACE and lenvatinib: a meta-analysis [0.03%]
免疫检查点抑制剂对不可切除肝细胞癌经导管动脉化疗栓塞和仑伐替尼治疗预后影响的meta分析
Wei Zhang,Zirong Liu,Hongjin Liu et al.
Wei Zhang et al.
Background: Combination of multiple therapies is a common approach to treating patients with unresectable hepatocellular carcinoma (uHCC). The impact of immune checkpoint inhibitors (ICIs) on prognosis in uHCC patients tr...
Deciphering the deterministic role of TCR signaling in T cell fate determination [0.03%]
TCR信号在T细胞命运决定中的确定性作用的解读
Zhen Qin,Tao Xu
Zhen Qin
T cell receptor (TCR) signaling, also known as signal 1, plays a crucial role in the activation and proliferation of T cells. The question of whether TCR signaling exerts a deterministic role in T cell fate determination is an area of activ...
Predominant T-cell epitopes of SARS-CoV-2 restricted by multiple prevalent HLA-B and HLA-C allotypes in Northeast Asia [0.03%]
在东亚地区常见的HLA-B和HLA-C等位基因限制的SARS-CoV-2主要T细胞表位
Yu Zhao,Min Peng,Chengtao He et al.
Yu Zhao et al.
Since the outbreak of novel coronavirus pneumonia (COVID-19), numerous T-cell epitopes in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) proteome have been reported. However, most of the identified CD8+ T-cell epitopes have be...
Risk factors for checkpoint inhibitor pneumonitis in lung cancer patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis [0.03%]
免疫检查点抑制剂治疗的肺癌患者发生肺毒性的危险因素：系统性回顾和荟萃分析
Xiaoqing Zhou,Yingnan Xu,Yuanyuan Ying et al.
Xiaoqing Zhou et al.
Background: Immune checkpoint inhibitors (ICIs) significantly improve survival in lung cancer patients. However, checkpoint inhibitor pneumonitis (CIP) remains a critical safety concern. This meta-analysis systematically ...