Remarkable increase in Interleukin-5 receptor expression beyond tissue eosinophils in inflammatory bowel disease [0.03%]
炎症性肠病中组织外周血嗜酸性粒细胞之外的IL-5受体表达显著升高
You Ie Kim,Hyeon Jeong Oh,Hye Ran Yang
You Ie Kim
Introduction: The role of tissue eosinophils and their relationship with interleukin-5 in gastrointestinal disorders have not been elucidated. This study aimed to analyze tissue eosinophils and interleukin-5 receptor-α s...
TIM3 and TIGIT-expressing CD4 T cells are impacted by kidney transplantation and associated with risk of infection [0.03%]
TIM3和TIGIT阳性CD4 T细胞受肾脏移植影响并与感染风险相关
Harry Pickering,Subha Sen,Monica Cappelletti et al.
Harry Pickering et al.
Introduction: Older kidney transplant patients experience higher rates of infection compared with younger transplant patients suggesting the impact of age-associated immune dysfunction. However, little is known about the ...
Single-cell and bulk transcriptome analyses reveal elevated amino acid metabolism promoting tumor-directed immune evasion in colorectal cancer [0.03%]
单细胞和bulk转录组分析揭示结直肠癌中增强的氨基酸代谢促进肿瘤免疫逃逸
Tianyue Sun,Yan Chen,Ying-Xuan Chen
Tianyue Sun
Introduction: Colorectal cancer (CRC), the third most common cancer worldwide, often shows limited responsiveness to immunotherapy due to its predominantly immune-excluded phenotype. Despite increasing insights into the c...
Transcriptomic insights into the mechanism of action of telomere-related biomarkers in rheumatoid arthritis [0.03%]
转录组学视角下端粒相关生物标志物在类风湿性关节炎作用机制的洞见
Lijuan Feng,Kaiyong Bai,Limeng He et al.
Lijuan Feng et al.
Background: Rheumatoid arthritis (RA) is an autoimmune inflammatory disease. The mechanism by which telomeres are involved in the development of RA remains unclear. This study aimed to investigate the relationship between...
ALG3 as a prognostic biomarker and mediator of PD-1 blockade resistance in hepatocellular carcinoma [0.03%]
ALG3作为肝细胞癌预后生物标志物及PD-1阻断耐药性的介导者
Pengju Tang,Zhenwei Han,Yiming Zhao et al.
Pengju Tang et al.
Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death globally, characterized by high heterogeneity and drug resistance, which significantly impacts clinical outcomes. The tumor microenviro...
Oral and intratumoral microbiota influence tumor immunity and patient survival [0.03%]
口腔和瘤内菌群影响肿瘤免疫及患者生存率
Kaitong Wei,Yaqing Ma,Jing Xu et al.
Kaitong Wei et al.
Background: The aim of this study was to analyze the changes in the oral microbiota of patients with oral squamous cell carcinoma (OSCC) compared to healthy controls and the effect of intratumoral microorganisms on the ho...
Immunogenicity risk assessment for tailored mitigation and monitoring of biotherapeutics during development: recommendations from the European Immunogenicity Platform [0.03%]
生物制剂研发过程中的免疫原性风险评估以进行量身定制的缓解和监测：欧洲免疫原性平台的建议
Joanna Grudzinska-Goebel,Karin Benstein,Karien Bloem et al.
Joanna Grudzinska-Goebel et al.
Bringing safe and effective drugs to patients is of utmost importance for the pharmaceutical industry, with immunogenicity (IG) being a critical factor that influences both aspects. Biotherapeutics can elicit unwanted immune responses, pote...
Joel Sop,Tyler P Beckey,Joel N Blankson
Joel Sop
HIV-1 alternative reading frame proteins (ARFPs) have been shown to elicit CD8+ T cell responses, but less is known about the recognition of these proteins by CD4+ T cells. In this study, we analyzed responses of CD8-depleted peripheral blo...
Peptide vaccines: an innovative therapeutic approach against antibiotic-resistant bacterial infections [0.03%]
肽疫苗：治疗抗生素耐药细菌感染的创新方法
Fatemeh Tavassoli Razavi,Nasrin Salari,Atena Emami et al.
Fatemeh Tavassoli Razavi et al.
Bacterial infections continue to pose a serious threat to global health, especially with the growing challenge of multidrug-resistant pathogens. While traditional vaccines have been pivotal in reducing disease burden, they come with limitat...
Lanadelumab for prevention of attacks of non-histaminergic normal C1 inhibitor angioedema: results from the randomized, double-blind CASPIAN Study and CASPIAN open-label extension [0.03%]
lanadelumab预防非组胺性正常C1酯酶抑制蛋白血管水肿发作：随机双盲CASPIAN研究及CASPIAN开放标签延伸研究结果
Marc A Riedl,Petra Staubach,Henriette Farkas et al.
Marc A Riedl et al.
Background: Randomized controlled trial data for non-histaminergic normal C1 inhibitor (nC1INH) angioedema prevention are lacking. Methods: ...
Clinical Trial
Frontiers in immunology. 2025 May 21:16:1502325. DOI:10.3389/fimmu.2025.1502325 2025