Clinical outcomes of newly diagnosed PCNSL treated with rituximab-methotrexate-cytarabine with or without ibrutinib: a retrospective study [0.03%]
利妥昔单抗甲氨蝶呤阿糖胞苷联合或不联合伊布替尼治疗新诊断PCNSL的临床疗效：一项回顾性研究
Wenhua Wang,Bingyi Wang,Yifei Sun et al.
Wenhua Wang et al.
Objective: This study aimed to evaluate the efficacy and safety of rituximab, methotrexate, cytarabine with or without ibrutinib in newly diagnosed primary central nervous system lymphoma (PCNSL) and explore the correlati...
Machine learning-driven identification of exosome- related biomarkers in head and neck squamous cell carcinoma [0.03%]
基于机器学习的头颈部鳞状细胞癌来源的外泌体相关标志物识别
Yaodong He,Yun Li,Jiaqi Tang et al.
Yaodong He et al.
Background: Head and neck squamous cell carcinoma (HNSCC) is a common cancer associated with elevated mortality rates. Exosomes, diminutive extracellular vesicles, significantly contribute to tumour development, immunolog...
Indoleamine 2,3-dioxygenase-1 expression in non-small-cell lung cancer: analyses of prevalence, clinical correlations and prognostic impact in 2 large patient cohorts [0.03%]
非小细胞肺癌中吲哚胺2,3双加氧酶-1的表达：一项大型患者的分析研究
Francesco Agustoni,Hui Yu,Kim Ellison et al.
Francesco Agustoni et al.
Background: Indoleamine 2,3-dioxygenase-1 (IDO-1) is a cytosolic enzyme involved in the catabolism of tryptophan. IDO-1-related immune suppression is due to decreased tryptophan availability and to the generation of trypt...
A high-saturated, long-chain fatty acid ketogenic diet negatively impacts visual and motor-sensory function in a pre-clinical model of multiple sclerosis [0.03%]
高饱和长链脂肪生酮饮食在多发性硬化症临床前模型中对视觉和运动感觉功能产生负面影响
Erin N Capper,Jeffrey J Anders,Benjamin W Elwood et al.
Erin N Capper et al.
Introduction: Multiple sclerosis (MS) is a neurodegenerative condition that results in demyelination of the central nervous system. Visual impairment, retinal nerve fiber layer thinning, and impaired electrical function i...
Tertiary lymphoid structures: exploring opportunities to improve immunotherapy in ovarian cancer [0.03%]
三级淋巴结构：探讨在卵巢癌中改善免疫治疗的机会
Aaron Varghese,Suzanne M Hess,Shanmuga Chilakapati et al.
Aaron Varghese et al.
Tertiary lymphoid structures (TLS) are organized ectopic lymphoid clusters of immune cells that develop in non-lymphoid tissue to promote antigen presentation, drive cytotoxic immune responses, and enhance humoral immunity via B cell clonal...
Applying computational protein design to therapeutic antibody discovery - current state and perspectives [0.03%]
计算型蛋白质设计在药物抗体发现中的应用及展望
Weronika Bielska,Igor Jaszczyszyn,Pawel Dudzic et al.
Weronika Bielska et al.
Machine learning applications in protein sciences have ushered in a new era for designing molecules in silico. Antibodies, which currently form the largest group of biologics in clinical use, stand to benefit greatly from this shift. Despit...
Metabolic profiles in laryngeal cancer defined two distinct molecular subtypes with divergent prognoses [0.03%]
喉癌代谢谱式定义了两种不同的分子亚型及预后判断
Dan Zheng,Xuan Pu,XuHui Deng et al.
Dan Zheng et al.
Background: Laryngeal cancer (LCA) is the second most common type of head and neck malignancy, characterized by high recurrence rates and poor overall survival (OS). However, progress in curing LCA through molecular-targe...
Distinct proteomic signatures in Ethiopians predict acute and long-term sequelae of COVID-19 [0.03%]
埃塞俄比亚人的不同蛋白质标志物可预测新冠肺炎的急性期和长期后遗症
Dawit Wolday,Abrha G Gebrehiwot,An Nguyen Le Minh et al.
Dawit Wolday et al.
Introduction: Little is known about the acute and long-term sequelae of COVID-19 and its pathophysiology in African patients, who are known to have a distinct immunological profile compared to Caucasian populations. Here,...
A case report of small cell neuroendocrine carcinoma of the ovary and review of the literature [0.03%]
卵巢小细胞神经内分泌癌一例并文献复习
Ying Zhao,Fuli Kang,Xiangshu Kong et al.
Ying Zhao et al.
Small cell neuroendocrine carcinoma of the ovary is rare pathological type with an undefined mechanism, low incidence, but high metastatic rate, high aggressiveness, and very poor prognosis, and there are no standardized treatment protocols...
Avidity of pertussis toxin antibodies following vaccination with genetically versus chemically detoxified pertussis toxin-containing vaccines during pregnancy [0.03%]
孕期接种基因型和化学型无细胞百日咳疫苗后白喉毒素抗体的亲和力
Bahaa Abu-Raya,Giuseppe Del Giudice,Anita H J van den Biggelaar et al.
Bahaa Abu-Raya et al.
Background: Both the quantity and quality of circulating anti-pertussis toxin antibodies are important for protection against severe pertussis. We compared the avidity of PT-IgG antibodies in pregnant women and their infa...
Comparative Study
Frontiers in immunology. 2025 May 22:16:1569151. DOI:10.3389/fimmu.2025.1569151 2025